EA201690622A1 - Соль дигидрофосфат тенофовира дизопроксила - Google Patents

Соль дигидрофосфат тенофовира дизопроксила

Info

Publication number
EA201690622A1
EA201690622A1 EA201690622A EA201690622A EA201690622A1 EA 201690622 A1 EA201690622 A1 EA 201690622A1 EA 201690622 A EA201690622 A EA 201690622A EA 201690622 A EA201690622 A EA 201690622A EA 201690622 A1 EA201690622 A1 EA 201690622A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tenofovir
dihydrophosphat
denoproxyl
salt
dihydrophosphate
Prior art date
Application number
EA201690622A
Other languages
English (en)
Inventor
Ян Голан
Лудек Ридван
Михаль Западло
Ондрей Даммер
Йосеф Беранек
Владимир Краль
Original Assignee
Зентива, К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива, К.С. filed Critical Зентива, К.С.
Publication of EA201690622A1 publication Critical patent/EA201690622A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)

Abstract

Тенофовира дизопроксила дигидрофосфат, имеющий следующие характеристические пики порошковой рентгеновской дифракции (ПРД), измеренной при излучении CuKα: 5,6; 7,7; 12,4; 13,6; 16,4; 22,4 и 25,4 ± 0,2° 2θ, и способы его получения.
EA201690622A 2013-10-09 2014-09-22 Соль дигидрофосфат тенофовира дизопроксила EA201690622A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13004844.0A EP2860184B1 (en) 2013-10-09 2013-10-09 Dihydrogenphosphate salt of Tenofovir disoproxil
PCT/EP2014/002562 WO2015051875A1 (en) 2013-10-09 2014-09-22 Dihydrogenphosphate salt of tenofovir disoproxil

Publications (1)

Publication Number Publication Date
EA201690622A1 true EA201690622A1 (ru) 2016-08-31

Family

ID=49354420

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690622A EA201690622A1 (ru) 2013-10-09 2014-09-22 Соль дигидрофосфат тенофовира дизопроксила

Country Status (10)

Country Link
EP (1) EP2860184B1 (ru)
JP (1) JP2016534047A (ru)
KR (1) KR20160067843A (ru)
CN (1) CN105612167A (ru)
BR (1) BR112016007617A2 (ru)
EA (1) EA201690622A1 (ru)
IL (1) IL244848A0 (ru)
MX (1) MX2016003757A (ru)
PT (1) PT2860184T (ru)
WO (1) WO2015051875A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160003532A (ko) * 2014-07-01 2016-01-11 한미약품 주식회사 테노포비어 디소프록실 인산염과, 비금속염 붕해제 및 비금속염 활택제를 포함하는 약학 조성물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122005000041I2 (de) 1996-07-26 2012-05-24 Gilead Sciences Inc Nukleotidanaloga.
WO1998004569A1 (en) 1996-07-26 1998-02-05 Gilead Sciences, Inc. Nucleotide analogs
US5935946A (en) 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
DE69831694T2 (de) 1997-07-25 2006-07-13 Gilead Sciences, Inc., Foster City Nukleotid-Analog Zusamensetzung und Synthese Verfahren
WO2007013086A1 (en) 2005-07-26 2007-02-01 Hetero Drugs Limited Novel polymorphs of tenofovir disoproxil fumarate
ES2532502T3 (es) 2006-07-12 2015-03-27 Mylan Laboratories Limited Proceso para la preparación de tenofovir
WO2008140302A1 (en) 2007-05-14 2008-11-20 Ultimorphix Technologies B.V. Polymorphic forms of tenofovir disoproxil fumarate
CN101778855A (zh) 2007-05-22 2010-07-14 阿尔迪默菲克斯技术有限责任公司 替诺福韦酯半富马酸共晶体
WO2009064174A1 (en) 2007-11-14 2009-05-22 Ultimorphix Technologies B.V. Polymorphic form of tenofovir disoproxil fumarate, method for its preparation and use
US20110009368A1 (en) 2007-12-12 2011-01-13 Ultimorphix Technologies B.V. Solid forms of tenofovir disoproxil
CA2722165C (en) 2008-04-25 2016-01-19 Cipla Limited Crystalline form of tenofovir disoproxil and a process for its preparation
EP2440560A1 (en) 2009-06-10 2012-04-18 Ultimorphix Technologies B.v. The succinate of tenofovir disoproxil
CN101781334B (zh) * 2010-03-04 2012-11-28 福建广生堂药业股份有限公司 替诺福韦酯的盐化合物，其制备方法和药物应用
US9650346B2 (en) * 2011-04-08 2017-05-16 Laurus Labs Private Ltd. Solid forms of antiretroviral compounds, process for the preparation and their pharmaceutical composition thereof
WO2013132314A1 (en) * 2012-03-05 2013-09-12 Laurus Labs Private Limited Tenofovir phosphate, processes for the preparation and pharmaceutical composition thereof

Also Published As

Publication number Publication date
IL244848A0 (en) 2016-05-31
EP2860184B1 (en) 2018-08-29
WO2015051875A1 (en) 2015-04-16
EP2860184A1 (en) 2015-04-15
JP2016534047A (ja) 2016-11-04
PT2860184T (pt) 2018-11-20
CN105612167A (zh) 2016-05-25
MX2016003757A (es) 2016-07-08
BR112016007617A2 (pt) 2017-08-01
KR20160067843A (ko) 2016-06-14

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