EA201690532A1 - Не содержащий консерванта офтальмологический фармацевтический состав - Google Patents

Не содержащий консерванта офтальмологический фармацевтический состав

Info

Publication number
EA201690532A1
EA201690532A1 EA201690532A EA201690532A EA201690532A1 EA 201690532 A1 EA201690532 A1 EA 201690532A1 EA 201690532 A EA201690532 A EA 201690532A EA 201690532 A EA201690532 A EA 201690532A EA 201690532 A1 EA201690532 A1 EA 201690532A1
Authority
EA
Eurasian Patent Office
Prior art keywords
conservative
pharmaceutical composition
ophthalmic
obtaining
formulation
Prior art date
Application number
EA201690532A
Other languages
English (en)
Other versions
EA030535B1 (ru
Inventor
Мандар В. Шах
Дипак Бахри
Маниш Кумар Сингх
Original Assignee
Сентисс Фарма Прайвет Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сентисс Фарма Прайвет Лимитед filed Critical Сентисс Фарма Прайвет Лимитед
Publication of EA201690532A1 publication Critical patent/EA201690532A1/ru
Publication of EA030535B1 publication Critical patent/EA030535B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Abstract

Настоящее изобретение относится к способу получения офтальмологического состава ингибитора карбоангидразы, гидроксилэтилцеллюлозы (ГЭЦ) и бета-адренергического антагониста для применения для лечения глазной гипертензии и глаукомы, причём указанный офтальмологический фармацевтический состав не содержит бензалкония хлорида или каких-либо других консервантов. Предложенный способ получения является более простым, экономически эффективным способом получения фармацевтического офтальмологического состава в одном резервуаре без использования дополнительных резервуаров, который может быть стерильно отфильтрован.
EA201690532A 2013-10-17 2014-10-13 Не содержащий консерванта офтальмологический фармацевтический состав EA030535B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2014/065262 WO2015056149A1 (en) 2013-10-17 2014-10-13 Preservative-free ophthalmic pharmaceutical formulation
IN3085DE2013 IN2013DE03085A (ru) 2013-10-17 2014-10-13

Publications (2)

Publication Number Publication Date
EA201690532A1 true EA201690532A1 (ru) 2016-09-30
EA030535B1 EA030535B1 (ru) 2018-08-31

Family

ID=52023563

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690532A EA030535B1 (ru) 2013-10-17 2014-10-13 Не содержащий консерванта офтальмологический фармацевтический состав

Country Status (7)

Country Link
US (1) US9801813B2 (ru)
EP (1) EP3057576A1 (ru)
CA (1) CA2924562A1 (ru)
EA (1) EA030535B1 (ru)
IN (1) IN2013DE03085A (ru)
UA (1) UA116273C2 (ru)
WO (1) WO2015056149A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230143595A1 (en) * 2020-03-31 2023-05-11 Sentiss Pharma Private Limited A sterilization process of timolol gel forming solution through aseptic filtration
CA3208138A1 (en) * 2021-01-21 2022-07-28 Kowa Company, Ltd. Methods of treating fuchs endothelial corneal dystrophy after descemetorhexis
CN112920138B (zh) * 2021-01-27 2023-03-07 成都摩尔生物医药有限公司 一种噻吗洛尔杂质的制备方法
KR20220169379A (ko) 2021-06-18 2022-12-27 대우제약 주식회사 고점도 점안제를 무균여과하는 방법
EP4309644A1 (en) * 2022-07-22 2024-01-24 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Preservative-free ophthalmic composition comprising an antiglaucoma agent

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438123A (en) * 1980-03-04 1984-03-20 Merck & Co., Inc. Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure
US4797413A (en) 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4731368A (en) 1986-12-08 1988-03-15 Merck & Co., Inc. Thienopyridine sulfonamides and their ophthalmological formulation
US4847289A (en) 1987-06-08 1989-07-11 Merck & Co., Inc. Thiophene sulfonamide antiglaucoma agents
US5153192A (en) 1990-04-09 1992-10-06 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US5378703A (en) 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
IE911192A1 (en) 1990-04-12 1991-10-23 Merck & Co Inc Substituted aromatic sulfonamides as antiglaucoma agents
US6071904A (en) * 1996-12-11 2000-06-06 Alcon Laboratories, Inc. Process for manufacturing ophthalmic suspensions
IT1395044B1 (it) 2009-06-30 2012-09-05 Marzoli Spa Apritoio a flusso assiale
TW201109325A (en) * 2009-07-30 2011-03-16 Wakamoto Pharma Co Ltd Aqueous composition for eye drops
AU2010325632B2 (en) * 2009-12-03 2014-01-30 Lupin Limited Process for preparing pharmaceutical ophthalmic compositions

Also Published As

Publication number Publication date
CA2924562A1 (en) 2015-04-23
UA116273C2 (uk) 2018-02-26
EP3057576A1 (en) 2016-08-24
EA030535B1 (ru) 2018-08-31
IN2013DE03085A (ru) 2015-04-24
WO2015056149A1 (en) 2015-04-23
US9801813B2 (en) 2017-10-31
US20160235665A1 (en) 2016-08-18

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ TJ TM