EA201591933A1 - Композиция с пониженной иммуногенностью - Google Patents

Композиция с пониженной иммуногенностью

Info

Publication number
EA201591933A1
EA201591933A1 EA201591933A EA201591933A EA201591933A1 EA 201591933 A1 EA201591933 A1 EA 201591933A1 EA 201591933 A EA201591933 A EA 201591933A EA 201591933 A EA201591933 A EA 201591933A EA 201591933 A1 EA201591933 A1 EA 201591933A1
Authority
EA
Eurasian Patent Office
Prior art keywords
composition
reduced immunogenicity
polyclonal antibodies
delyramic
neu5gc
Prior art date
Application number
EA201591933A
Other languages
English (en)
Other versions
EA038968B1 (ru
Inventor
Жан-Поль Сулийу
Магали Жираль
Грегуар Кувра-Девернь
Original Assignee
Институт Насьональ Де Ла Сант Эт Де Ла Решерш Медикаль
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт Насьональ Де Ла Сант Эт Де Ла Решерш Медикаль filed Critical Институт Насьональ Де Ла Сант Эт Де Ла Решерш Медикаль
Publication of EA201591933A1 publication Critical patent/EA201591933A1/ru
Publication of EA038968B1 publication Critical patent/EA038968B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39516—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum from serum, plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к композиции, содержащей поликлональные антитела к клеткам человека, причем указанные поликлональные антитела лишены первой антигенной детерминанты, выбранной из группы, содержащей (i) N-гликольнейраминовую кислоту (Neu5Gc) и (ii) α-1,3-галактозу, и ее применению в качестве лекарственного средства.
EA201591933A 2013-04-18 2014-04-17 Композиция с пониженной иммуногенностью EA038968B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13305507 2013-04-18
PCT/IB2014/060813 WO2014170867A1 (en) 2013-04-18 2014-04-17 Composition with reduced immunogenicity

Publications (2)

Publication Number Publication Date
EA201591933A1 true EA201591933A1 (ru) 2016-02-29
EA038968B1 EA038968B1 (ru) 2021-11-16

Family

ID=48227107

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591933A EA038968B1 (ru) 2013-04-18 2014-04-17 Композиция с пониженной иммуногенностью

Country Status (10)

Country Link
US (1) US11084871B2 (ru)
EP (1) EP2986639B1 (ru)
CN (1) CN105263960B (ru)
AU (1) AU2014255285B2 (ru)
CA (1) CA2909139C (ru)
EA (1) EA038968B1 (ru)
ES (1) ES2894837T3 (ru)
PL (1) PL2986639T3 (ru)
WO (1) WO2014170867A1 (ru)
ZA (1) ZA201507770B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015332634B2 (en) * 2014-10-15 2020-05-14 Xenothera Composition with reduced immunogenicity

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629347B1 (fr) 1988-04-01 1991-06-14 Merieux Inst Procede de preparation d'un serum antilymphocytaire par immunisation d'animaux a l'aide d'un clone de lymphoblaste t humain, et serum antilymphocytaire ainsi obtenu
GB8905669D0 (en) * 1989-03-13 1989-04-26 Celltech Ltd Modified antibodies
JPH07155194A (ja) 1993-12-10 1995-06-20 Teijin Ltd タンパク質の精製法
WO2003055302A1 (en) 2001-12-21 2003-07-10 The Curators Of The University Of Missouri Knockout swine and methods for making the same
AU2003210802B2 (en) 2002-02-05 2009-09-10 Genentech Inc. Protein purification
WO2003097812A2 (en) * 2002-05-17 2003-11-27 Hematech, Llc Transgenic ungulates capable of human antibody production
AU2004215653B2 (en) 2003-02-28 2011-03-17 Lonza Biologics Plc. Antibody purification by protein A and ion exchange chromatography
DE602005022728D1 (de) 2004-08-19 2010-09-16 Univ Cardiff Präparation antigenpräsentierender menschlicher gamma delta t-zellen und verwendung in der immuntherapie
US20080166805A1 (en) 2005-06-08 2008-07-10 The Regents Of The University Of California Culturing human cells and tissues in an N-glycolylneuraminic acid-free environment
EP3456351A1 (en) 2006-04-05 2019-03-20 The Rockefeller University Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
US8540992B2 (en) * 2006-12-28 2013-09-24 Michael Naso Methods and vectors for generating asialylated immunoglobulins
FR2942233B1 (fr) 2009-02-19 2015-03-13 Lfb Biotechnologies Moyens pour la purification d'une proteine du plasma sanguin, et procedes pour sa mise en oeuvre
CN102893154A (zh) * 2010-01-15 2013-01-23 加利福尼亚大学董事会 用于检测癌症的组合物和方法
US8980583B2 (en) * 2011-06-30 2015-03-17 Sigma-Aldrich Co. Llc Cells deficient in CMP-N-acetylneuraminic acid hydroxylase and/or glycoprotein alpha-1,3-galactosyltransferase
AU2015332634B2 (en) * 2014-10-15 2020-05-14 Xenothera Composition with reduced immunogenicity

Also Published As

Publication number Publication date
AU2014255285A1 (en) 2015-11-12
CA2909139C (en) 2021-07-06
ES2894837T3 (es) 2022-02-16
US11084871B2 (en) 2021-08-10
EA038968B1 (ru) 2021-11-16
AU2014255285B2 (en) 2019-07-11
EP2986639B1 (en) 2021-08-11
CN105263960A (zh) 2016-01-20
PL2986639T3 (pl) 2022-01-10
CN105263960B (zh) 2020-05-22
WO2014170867A1 (en) 2014-10-23
EP2986639A1 (en) 2016-02-24
ZA201507770B (en) 2017-02-22
CA2909139A1 (en) 2014-10-23
US20160075770A1 (en) 2016-03-17

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