EA201590745A1 - SOLID ORAL PHARMACEUTICAL COMPOSITION CONTAINING TIKAGRELOR - Google Patents

SOLID ORAL PHARMACEUTICAL COMPOSITION CONTAINING TIKAGRELOR

Info

Publication number
EA201590745A1
EA201590745A1 EA201590745A EA201590745A EA201590745A1 EA 201590745 A1 EA201590745 A1 EA 201590745A1 EA 201590745 A EA201590745 A EA 201590745A EA 201590745 A EA201590745 A EA 201590745A EA 201590745 A1 EA201590745 A1 EA 201590745A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical composition
solid oral
oral pharmaceutical
composition containing
tikagrelor
Prior art date
Application number
EA201590745A
Other languages
Russian (ru)
Inventor
Грегор Седмак
Original Assignee
Зентива, К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива, К.С. filed Critical Зентива, К.С.
Publication of EA201590745A1 publication Critical patent/EA201590745A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

В изобретении предложена твердая пероральная фармацевтическая композиция, содержащая тикагрелор с химическим наименованием (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-дифторфенил)циклопропил]амино]-5-(пропилтио)-3Н-1,2,3-триазоло[4,5-d]пиримидин-3-ил]-5-(2-гидроксиэтокси)-1,2-циклопентандиол, содержащая по меньшей мере один негигроскопичный наполнитель и/или по меньшей мере одно негигроскопичное связывающее вещество, где ни наполнитель, ни связывающее вещество не оказывают какого-либо разрыхляющего эффекта. Получение композиции возможно при помощи влажной грануляции, сухой грануляции или прямого прессования.The invention proposed a solid oral pharmaceutical composition containing ticagrelor with the chemical name (1S, 2S, 3R, 5S) -3- [7 - [[(1R, 2S) -2- (3,4-difluorophenyl) cyclopropyl] amino] - 5- (propylthio) -3H-1,2,3-triazolo [4,5-d] pyrimidin-3-yl] -5- (2-hydroxyethoxy) -1,2-cyclopentanediol containing at least one non-hygroscopic filler and / or at least one non-hygroscopic binder, where neither the filler nor the binder has any loosening effect. The composition can be obtained by wet granulation, dry granulation or direct compression.

EA201590745A 2012-10-16 2013-10-15 SOLID ORAL PHARMACEUTICAL COMPOSITION CONTAINING TIKAGRELOR EA201590745A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ2012-705A CZ2012705A3 (en) 2012-10-16 2012-10-16 Solid oral pharmaceutical formulation containing ticagrelor
PCT/CZ2013/000130 WO2014059955A1 (en) 2012-10-16 2013-10-15 A solid oral pharmaceutical formulation containing ticagrelor

Publications (1)

Publication Number Publication Date
EA201590745A1 true EA201590745A1 (en) 2015-08-31

Family

ID=49619770

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590745A EA201590745A1 (en) 2012-10-16 2013-10-15 SOLID ORAL PHARMACEUTICAL COMPOSITION CONTAINING TIKAGRELOR

Country Status (13)

Country Link
EP (1) EP2908802A1 (en)
JP (1) JP6301934B2 (en)
KR (1) KR20150067153A (en)
CN (1) CN104661649A (en)
BR (1) BR112015008076A2 (en)
CZ (1) CZ2012705A3 (en)
EA (1) EA201590745A1 (en)
HK (1) HK1205456A1 (en)
IL (1) IL238036B (en)
MX (1) MX2015003866A (en)
UA (1) UA116784C2 (en)
WO (1) WO2014059955A1 (en)
ZA (1) ZA201501954B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160012706A (en) * 2014-07-25 2016-02-03 동아에스티 주식회사 Sustained release formulations
CN106074357B (en) * 2015-04-29 2021-07-02 江苏恒瑞医药股份有限公司 Ticagrelor preparation of pharmaceutically acceptable salt thereof
CN105193759B (en) * 2015-09-18 2018-07-03 乐普药业股份有限公司 A kind of ticagrelor piece and preparation method thereof
CN106667926B (en) * 2015-11-09 2020-01-17 石药集团中奇制药技术（石家庄）有限公司 Favipiravir tablet and preparation method thereof
TR201601835A2 (en) * 2016-02-12 2017-08-21 Ali Raif Ilac Sanayi Ve Ticaret Anonim Sirketi PRODUCTION METHOD FOR FORMULATIONS CONTAINING TIKAGRELOR
EA201892150A1 (en) * 2016-04-21 2019-05-31 Астразенека Аб DECOMING IN THE ORAL CAVITY TABLETS
TR201617983A2 (en) * 2016-12-07 2018-06-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi SOLID ORAL PHARMACEUTICAL COMPOSITIONS OF TICAGRELOR
KR102610876B1 (en) * 2018-03-05 2023-12-06 주식회사 파마코스텍 Crystal form I of Ticagrelor Fumarateand its preparing method
WO2019170244A1 (en) 2018-03-08 2019-09-12 Pharmaceutical Oriented Services Ltd. Ticagrelor—containing tablet formulation
WO2020021110A1 (en) 2018-07-27 2020-01-30 Krka, D.D., Novo Mesto Pharmaceutical composition of ticagrelor
CN111450067A (en) * 2019-01-18 2020-07-28 北京万全德众医药生物技术有限公司 Ticagrelor dispersible tablet and preparation method thereof
CN116370423A (en) * 2023-02-28 2023-07-04 天津力生制药股份有限公司 Ticagrelor orally disintegrating tablet and preparation method thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR017014A1 (en) 1997-07-22 2001-08-22 Astrazeneca Ab TRIAZOL COMPOUNDS [4,5-D] PYRIMIDINE, PHARMACEUTICAL COMPOSITIONS, USE OF THE SAME TO PREPARE MEDICATIONS AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS
JPH11199517A (en) * 1997-10-31 1999-07-27 Meiji Seika Kaisha Ltd Intraoral fast disintegrable tablet
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013407D0 (en) 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
WO2007018057A1 (en) * 2005-08-05 2007-02-15 Freund Corporation Tablet rapidly disintegrating in the oral cavity and method of producing the same
TWI482772B (en) * 2006-08-21 2015-05-01 Astrazeneca Ab Compositions, suitable for oral administration, comprising a triazolo(4,5-d)pyrimidin derivate
WO2008024044A1 (en) * 2006-08-21 2008-02-28 Astrazeneca Ab Compositions, suitable for oral administration, comprising a triazolo [4, 5] pyrimidin derivate
CA2781182A1 (en) 2009-12-03 2011-06-09 Astrazeneca Ab Co - crystals of a triazolo [4,5 - d] pyrimidine platelet aggregation inhibitor
EA026094B1 (en) * 2009-12-23 2017-03-31 Рациофарм Гмбх Solid dosage form of ticagrelor

Also Published As

Publication number Publication date
ZA201501954B (en) 2017-04-26
EP2908802A1 (en) 2015-08-26
IL238036B (en) 2019-05-30
WO2014059955A1 (en) 2014-04-24
JP2015533129A (en) 2015-11-19
IL238036A0 (en) 2015-05-31
HK1205456A1 (en) 2015-12-18
JP6301934B2 (en) 2018-03-28
KR20150067153A (en) 2015-06-17
BR112015008076A2 (en) 2017-07-04
CZ2012705A3 (en) 2014-04-23
UA116784C2 (en) 2018-05-10
CN104661649A (en) 2015-05-27
MX2015003866A (en) 2015-07-17

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