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Application filed by Astrazeneca AbfiledCriticalAstrazeneca Ab
Priority claimed from PCT/EP2017/059443external-prioritypatent/WO2017182589A1/en
Publication of MY194359ApublicationCriticalpatent/MY194359A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
The present invention relates to rapidly disintegrating oral dosage forms, more particularly to rapidly disintegrating tablets containing (1S,2S,3R,5S)-3-[7-{[(1R,2S)-2-(3,4- difluorophenyl)cyclopropyl]amino}-5-(propylthio)-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-3-yl]- 5-(2-hydroxyethoxy)cyclopentane-1,2-diol and a disintegrating excipient. Blister packs suitable for use with the rapidly disintegrating oral dosage form are also disclosed.
Substituted bicyclic compounds; pharmaceutical composition that includes them; and use in the treatment of diseases such as cancer, Alzheimer's, AIDS, among others.
Compounds derived from 3- [4- (7h-pyrrolo [2,3-d] pyrimidin-4-yl) -1h-pyrazol-1-yl] octanonitrile or heptanonitrile or their salts, as jak inhibitors; preparation procedure; pharmaceutical composition comprising them; Useful for the treatment of autoimmune disorders, cancer, among other diseases.
Compounds derived from furo [3,2-d] pyrimidine and their salts; pharmaceutical composition that includes them; and its use to treat a condition that is mediated by the activity of a protein kinase, such as cancer, cardiovascular, CNS and immune disorders, and diseases related to acquired immunodeficiency.
Crystalline forms of (2r,5s,13ar)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido [1',2':4,5] pyrazino [2,1-b] [1,3] oxazepine-10-carboxamide