EA024825B8 - Cocrystal of ticagrelor with 3-hydroxy-2-naphthoic acid, process for preparation thereof and use - Google Patents

Cocrystal of ticagrelor with 3-hydroxy-2-naphthoic acid, process for preparation thereof and use

Info

Publication number
EA024825B8
EA024825B8 EA201590112A EA201590112A EA024825B8 EA 024825 B8 EA024825 B8 EA 024825B8 EA 201590112 A EA201590112 A EA 201590112A EA 201590112 A EA201590112 A EA 201590112A EA 024825 B8 EA024825 B8 EA 024825B8
Authority
EA
Eurasian Patent Office
Prior art keywords
preparation
ticagrelor
hydroxy
naphthoic acid
cocrystal
Prior art date
Application number
EA201590112A
Other languages
Russian (ru)
Other versions
EA201590112A1 (en
EA024825B1 (en
Inventor
Шармарке Мохамед
Людмила Гейтманкова
Лудек Ридван
Марцела Ткадлецова
Ондрей Даммер
Original Assignee
Зентива, К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива, К.С. filed Critical Зентива, К.С.
Publication of EA201590112A1 publication Critical patent/EA201590112A1/en
Publication of EA024825B1 publication Critical patent/EA024825B1/en
Publication of EA024825B8 publication Critical patent/EA024825B8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Solid state structures of (1S,2S,3R,5S)-3-[7-[1R,2S)-2-(3,4-difluorophenyl)cyclopropylamino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol (hereafter referred to as Ticagrelor) in the form of a stable 3-hydroxy-2-naphthoic acid co-crystal form, a process for the preparation thereof and the use for preparation of a pharmaceutical composition.
EA201590112A 2012-06-29 2012-06-29 Cocrystal of ticagrelor with 3-hydroxy-2-naphthoic acid, process for preparation thereof and use EA024825B8 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CZ2012/000059 WO2014000719A1 (en) 2012-06-29 2012-06-29 Novel pharmaceutical solid forms of (1s,2s,3r,5s)-3-[7-[(1r,2s)-2-(3,4difluorophenyl)cyclopropylamino]-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3yl]-5-(2-hydroxyethoxy)cyclopentane-l,2-diol

Publications (3)

Publication Number Publication Date
EA201590112A1 EA201590112A1 (en) 2015-05-29
EA024825B1 EA024825B1 (en) 2016-10-31
EA024825B8 true EA024825B8 (en) 2016-12-30

Family

ID=46583808

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590112A EA024825B8 (en) 2012-06-29 2012-06-29 Cocrystal of ticagrelor with 3-hydroxy-2-naphthoic acid, process for preparation thereof and use

Country Status (4)

Country Link
EP (1) EP2867235A1 (en)
BR (1) BR112014032085A2 (en)
EA (1) EA024825B8 (en)
WO (1) WO2014000719A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
WO2016116942A1 (en) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin
US10905691B2 (en) 2016-09-09 2021-02-02 Université de Liège Use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection
ES2731658T3 (en) * 2016-09-09 2019-11-18 Univ Liege Triazolo (4,5-d) pyrimidine derivatives for use in the prevention and treatment of bacterial infection
WO2018178997A1 (en) * 2017-03-31 2018-10-04 Natco Pharma Limited Novel crystalline form of ticagrelor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034283A1 (en) * 1998-12-04 2000-06-15 Astrazeneca Ab Novel triazolo(4,5-d)pyrimidine compounds
WO2001092262A1 (en) * 2000-06-02 2001-12-06 Astrazeneca Ab New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound
WO2011067571A1 (en) * 2009-12-03 2011-06-09 Astrazeneca Ab Co - crystals of a triazolo [4,5 - d] pyrimidine platelet aggregation inhibitor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034283A1 (en) * 1998-12-04 2000-06-15 Astrazeneca Ab Novel triazolo(4,5-d)pyrimidine compounds
WO2001092262A1 (en) * 2000-06-02 2001-12-06 Astrazeneca Ab New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound
WO2011067571A1 (en) * 2009-12-03 2011-06-09 Astrazeneca Ab Co - crystals of a triazolo [4,5 - d] pyrimidine platelet aggregation inhibitor

Also Published As

Publication number Publication date
EA201590112A1 (en) 2015-05-29
EP2867235A1 (en) 2015-05-06
WO2014000719A1 (en) 2014-01-03
BR112014032085A2 (en) 2017-06-27
EA024825B1 (en) 2016-10-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU