EA201590694A1 - Ly75 как мишень для терапии и диагностики злокачественных опухолей - Google Patents

Ly75 как мишень для терапии и диагностики злокачественных опухолей

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Publication number
EA201590694A1
EA201590694A1 EA201590694A EA201590694A EA201590694A1 EA 201590694 A1 EA201590694 A1 EA 201590694A1 EA 201590694 A EA201590694 A EA 201590694A EA 201590694 A EA201590694 A EA 201590694A EA 201590694 A1 EA201590694 A1 EA 201590694A1
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Prior art keywords
cancer
malignant tumors
diagnostics
therapy
target
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EA201590694A
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English (en)
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EA033649B1 (ru
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Джеймс Эдвард Акройд
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Оксфорд Байотерапьютикс Лтд.
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Application filed by Оксфорд Байотерапьютикс Лтд. filed Critical Оксфорд Байотерапьютикс Лтд.
Publication of EA201590694A1 publication Critical patent/EA201590694A1/ru
Publication of EA033649B1 publication Critical patent/EA033649B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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Abstract

Изобретение относится к способам и композициям для лечения, скрининга, диагностики и прогнозирования злокачественной опухоли, такой как лимфома, миелома, лейкоз, рак щитовидной железы, рак мочевого пузыря, рак молочной железы, рак желудка, рак пищевода, рак головы и шеи и рак кожи, мониторинга эффективности лечения злокачественной опухоли, такой как лимфома, миелома, лейкоз, рак щитовидной железы, рак мочевого пузыря, рак молочной железы, рак желудка, рак пищевода, рак головы и шеи и рак кожи, злокачественных опухолей, и разработки лекарственных средств.
EA201590694A 2012-11-07 2013-11-06 Способ лечения злокачественной опухоли с использованием конъюгатов, содержащих анти-ly75 антитело и цитотоксический агент EA033649B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1220010.1A GB201220010D0 (en) 2012-11-07 2012-11-07 Therapeutic amd diagnostic target
PCT/GB2013/052899 WO2014072700A1 (en) 2012-11-07 2013-11-06 Ly75 as cancer therapeutic and diagnostic target

Publications (2)

Publication Number Publication Date
EA201590694A1 true EA201590694A1 (ru) 2015-09-30
EA033649B1 EA033649B1 (ru) 2019-11-13

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ID=47429281

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Application Number Title Priority Date Filing Date
EA201590694A EA033649B1 (ru) 2012-11-07 2013-11-06 Способ лечения злокачественной опухоли с использованием конъюгатов, содержащих анти-ly75 антитело и цитотоксический агент

Country Status (15)

Country Link
US (3) US20150297743A1 (ru)
EP (1) EP2917239A1 (ru)
JP (4) JP2016501843A (ru)
KR (1) KR102256552B1 (ru)
CN (2) CN113181372A (ru)
AU (2) AU2013343277B2 (ru)
BR (1) BR112015009438B1 (ru)
CL (1) CL2015001098A1 (ru)
EA (1) EA033649B1 (ru)
GB (1) GB201220010D0 (ru)
HK (1) HK1214611A1 (ru)
NZ (1) NZ707116A (ru)
SG (2) SG11201503363WA (ru)
UA (1) UA117569C2 (ru)
WO (1) WO2014072700A1 (ru)

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GB201220010D0 (en) * 2012-11-07 2012-12-19 Oxford Biotherapeutics Ltd Therapeutic amd diagnostic target
PT3055331T (pt) 2013-10-11 2021-04-05 Oxford Bio Therapeutics Ltd Anticorpos conjugados contra ly75 para o tratamento de cancro
WO2016193117A1 (en) 2015-05-29 2016-12-08 Universiteit Maastricht Method for identifying subjects with aggressive melanoma skin cancer at diagnosis
KR101796091B1 (ko) 2016-05-02 2017-11-10 충남대학교 산학협력단 카복실 말단 조절 단백질을 포함하는 두경부암 진단용 바이오 마커 조성물
GB201703876D0 (en) 2017-03-10 2017-04-26 Berlin-Chemie Ag Pharmaceutical combinations
GB201809746D0 (en) * 2018-06-14 2018-08-01 Berlin Chemie Ag Pharmaceutical combinations
CN109685135B (zh) * 2018-12-21 2022-03-25 电子科技大学 一种基于改进型度量学习的少样本图像分类方法
EP4065599A4 (en) * 2019-11-26 2023-11-01 Cedars-Sinai Medical Center COMPOSITIONS AND METHODS FOR TREATING ILLNESSES AND CONDITIONS BY REMOVING MITOCHONDRIAL OR GENOMIC DNA FROM THE CIRCULATION
JPWO2023032995A1 (ru) 2021-08-31 2023-03-09
WO2023032994A1 (ja) 2021-08-31 2023-03-09 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
WO2023032996A1 (ja) 2021-08-31 2023-03-09 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
WO2023039580A2 (en) * 2021-09-13 2023-03-16 Regeneron Pharmaceuticals, Inc. Methods of treating clonal hematopoiesis of indeterminate potential (chip) with lymphocyte antigen 75 (ly75), cluster of differentiation 164 (cd164), or poly(adp-ribose) polymerase 1 (parp1) inhibitors

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AU2013343277B2 (en) 2018-03-08
KR102256552B1 (ko) 2021-05-25
KR20150082278A (ko) 2015-07-15
SG11201503363WA (en) 2015-06-29
CN104755496A (zh) 2015-07-01
EP2917239A1 (en) 2015-09-16
WO2014072700A1 (en) 2014-05-15
AU2018203478A1 (en) 2018-06-07
JP2018188463A (ja) 2018-11-29
JP2023011880A (ja) 2023-01-24
AU2013343277A1 (en) 2015-05-07
BR112015009438B1 (pt) 2023-03-14
JP7479435B2 (ja) 2024-05-08
US20150297743A1 (en) 2015-10-22
JP2016501843A (ja) 2016-01-21
SG10201810357WA (en) 2018-12-28
US20210346512A1 (en) 2021-11-11
JP2021011483A (ja) 2021-02-04
NZ707116A (en) 2019-07-26
CN113181372A (zh) 2021-07-30
HK1214611A1 (zh) 2016-07-29
GB201220010D0 (en) 2012-12-19
AU2018203478B2 (en) 2020-02-06
UA117569C2 (uk) 2018-08-27
US20190317100A1 (en) 2019-10-17
CL2015001098A1 (es) 2015-09-25
JP7079685B2 (ja) 2022-06-02
EA033649B1 (ru) 2019-11-13
BR112015009438A2 (pt) 2017-11-14

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