EA201590529A1 - Фармацевтическая композиция, содержащая ингибитор апф и блокатор кальциевых каналов - Google Patents

Фармацевтическая композиция, содержащая ингибитор апф и блокатор кальциевых каналов

Info

Publication number
EA201590529A1
EA201590529A1 EA201590529A EA201590529A EA201590529A1 EA 201590529 A1 EA201590529 A1 EA 201590529A1 EA 201590529 A EA201590529 A EA 201590529A EA 201590529 A EA201590529 A EA 201590529A EA 201590529 A1 EA201590529 A1 EA 201590529A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical composition
calcium channel
channel blocker
ace inhibitor
composition containing
Prior art date
Application number
EA201590529A
Other languages
English (en)
Other versions
EA027568B1 (ru
Inventor
Эльжбета Турчынь
Original Assignee
Адамед Сп. З О.О.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49724636&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201590529(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Адамед Сп. З О.О. filed Critical Адамед Сп. З О.О.
Publication of EA201590529A1 publication Critical patent/EA201590529A1/ru
Publication of EA027568B1 publication Critical patent/EA027568B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Фармацевтическая композиция в форме смеси, состоящая из а) порошка, содержащего ингибитор АПФ, и b) гранулята, содержащего блокатор кальциевых каналов, отличающаяся тем, что порошок а) и гранулят b) содержат одно или более вспомогательных веществ. Композиция подходит для лечения состояний, связанных с гипертензией.
EA201590529A 2012-11-15 2013-11-12 Фармацевтическая композиция, содержащая ингибитор апф и блокатор кальциевых каналов EA027568B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL401632A PL227900B1 (pl) 2012-11-15 2012-11-15 Kompozycja farmaceutyczna zawierająca inhibitor ACE i bloker kanałów wapniowych, sposób jej wytwarzania i jednostka dawkowania zawierająca tę kompozycję
PCT/IB2013/060069 WO2014076632A1 (en) 2012-11-15 2013-11-12 A pharmaceutical composition containing an ace inhibitor and a calcium channel blocker

Publications (2)

Publication Number Publication Date
EA201590529A1 true EA201590529A1 (ru) 2015-09-30
EA027568B1 EA027568B1 (ru) 2017-08-31

Family

ID=49724636

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590529A EA027568B1 (ru) 2012-11-15 2013-11-12 Фармацевтическая композиция, содержащая ингибитор апф и блокатор кальциевых каналов

Country Status (18)

Country Link
EP (1) EP2919815B1 (ru)
AU (1) AU2013346397B2 (ru)
BR (1) BR112015010119A2 (ru)
EA (1) EA027568B1 (ru)
ES (1) ES2650468T3 (ru)
HK (1) HK1213807A1 (ru)
HR (1) HRP20171863T1 (ru)
HU (1) HUE035163T2 (ru)
MX (1) MX353689B (ru)
MY (1) MY170451A (ru)
PH (1) PH12015501036B1 (ru)
PL (2) PL227900B1 (ru)
PT (1) PT2919815T (ru)
RS (1) RS56664B1 (ru)
SG (1) SG11201503441XA (ru)
UA (1) UA114439C2 (ru)
WO (1) WO2014076632A1 (ru)
ZA (1) ZA201504265B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3275432A1 (en) * 2016-07-25 2018-01-31 H e x a l Aktiengesellschaft Dosage form with ace inhibitor
WO2021160700A1 (en) * 2020-02-10 2021-08-19 Adamed Pharma S.A. Composition comprising ramipril and indapamide
GB2595203A (en) * 2020-03-03 2021-11-24 Alkaloid Ad Skopje Formulation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743450A (en) 1987-02-24 1988-05-10 Warner-Lambert Company Stabilized compositions
DE3739690A1 (de) 1987-11-24 1989-06-08 Hoechst Ag Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen
US5093129A (en) 1989-01-30 1992-03-03 E. R. Squibb & Sons, Inc. Method for treating addiction to a drug of abuse employing an ace inhibitor
BR0003282A (pt) 2000-07-14 2002-02-26 Libbs Farmaceutica Ltda Associação farmacêutica para tratamento da hipertenção arterial e prevenção de doenças cardiovasculares outras, como infarto do miocárdio, acidente vascular cerebral e insuficiências cardìaca e renal
CA2357982A1 (en) 2001-09-28 2003-03-28 Bernard Charles Sherman Solid compositions comprising ramipril
ES2283774T3 (es) 2002-01-15 2007-11-01 Actavis Group Hf. Formulaciones de quinapril e inhibidores de la eca relacionados.
US20030215526A1 (en) 2002-03-08 2003-11-20 Scott Stofik Stable formulations of angiotensin converting enzyme (ACE) inhibitors
US20050181055A1 (en) 2003-10-08 2005-08-18 Mathur Rajeev S. Pharmaceutical compositions of quinapril
LT1729739T (lt) 2004-03-29 2016-11-10 Les Laboratoires Servier Kietos farmacinės kompozicijos gamybos būdas
HUP0401170A2 (en) * 2004-06-10 2006-09-28 Richter Gedeon Vegyeszet Pharmaceutical composition comprising amlodipine besilate and lisinopril dihydrate and process for
MX2007011119A (es) 2005-03-15 2007-11-14 Lupin Ltd Composiciones farmaceuticas de amlodipino y benazepril.
JP2009508948A (ja) 2005-09-28 2009-03-05 テバ ファーマシューティカル インダストリーズ リミティド アムロジピンベシレート及びベナゼプリル塩酸塩の安定した組合わせ
WO2007056442A1 (en) 2005-11-07 2007-05-18 King Pharmaceuticals Research & Development, Inc. Compositions of stabilized ramipril in combination with another active agent
WO2008065485A2 (en) 2006-10-19 2008-06-05 Torrent Pharmaceuticals Limited Stable pharmaceutical compositions of a calcium channel blocker and an ace inhibitor
PL2538924T3 (pl) 2010-02-24 2014-10-31 Sanofi Aventis Deutschland Stałe formulacje farmaceutyczne ramiprylu i benzenosulfonianu amlodypiny oraz ich wytwarzanie

Also Published As

Publication number Publication date
AU2013346397B2 (en) 2017-09-14
PL401632A1 (pl) 2014-05-26
PL2919815T3 (pl) 2018-01-31
MX2015006122A (es) 2015-08-05
EP2919815A1 (en) 2015-09-23
WO2014076632A1 (en) 2014-05-22
PL227900B1 (pl) 2018-01-31
AU2013346397A1 (en) 2015-06-18
BR112015010119A2 (pt) 2017-07-11
HRP20171863T1 (hr) 2018-01-12
UA114439C2 (uk) 2017-06-12
MX353689B (es) 2018-01-23
EA027568B1 (ru) 2017-08-31
EP2919815B1 (en) 2017-09-06
MY170451A (en) 2019-07-31
SG11201503441XA (en) 2015-05-28
RS56664B1 (sr) 2018-03-30
HK1213807A1 (zh) 2016-07-15
PH12015501036A1 (en) 2015-08-17
ZA201504265B (en) 2017-11-29
ES2650468T3 (es) 2018-01-18
PT2919815T (pt) 2017-12-11
HUE035163T2 (en) 2018-05-02
PH12015501036B1 (en) 2015-08-17

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PD4A Registration of transfer of a eurasian patent in accordance with the succession in title