EA201590351A1 - Комбинации с пептидом с циклизованной основной цепью - Google Patents

Комбинации с пептидом с циклизованной основной цепью

Info

Publication number
EA201590351A1
EA201590351A1 EA201590351A EA201590351A EA201590351A1 EA 201590351 A1 EA201590351 A1 EA 201590351A1 EA 201590351 A EA201590351 A EA 201590351A EA 201590351 A EA201590351 A EA 201590351A EA 201590351 A1 EA201590351 A1 EA 201590351A1
Authority
EA
Eurasian Patent Office
Prior art keywords
infections
diseases
cyclized
main chain
peptide combinations
Prior art date
Application number
EA201590351A
Other languages
English (en)
Other versions
EA030077B1 (ru
Inventor
Гленн Е. Дале
Даниэль Обрехт
Франческа Бернардини
Original Assignee
Полифор Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Полифор Аг filed Critical Полифор Аг
Publication of EA201590351A1 publication Critical patent/EA201590351A1/ru
Publication of EA030077B1 publication Critical patent/EA030077B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Новая комбинация, содержащая β-шпилечный пептидометик формулыа также соединение глицилциклинового класса, в частности тигециклин, которая обеспечивает терапевтический контроль специфичных бактериальных инфекций у человека или животных при дозах отдельных соединений, более низких, чем когда соединения вводятся сами по себе. Комбинация может применяться в качестве лекарственного средства для лечения, например, кожных или мышечных инфекций; глазных инфекций, ушных инфекций, инфекций кровяного русла или интраабдоминальных инфекций; инфекций, связанных с заболеваниями органов дыхания, с заболеваниями костей, с сердечно-сосудистыми заболеваниями, с заболеваниями мочеполовой системы или с желудочно-кишечными заболеваниями.
EA201590351A 2012-08-08 2013-08-07 КОМБИНАЦИЯ, СОДЕРЖАЩАЯ β-ШПИЛЕЧНЫЙ ПЕПТИДОМИМЕТИК И ТИГЕЦИКЛИН, ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИЙ, ВЫЗВАННЫХ PSEUDOMONAS AERUGINOSA, И ЕЕ ПРИМЕНЕНИЕ EA030077B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12005744 2012-08-08
PCT/EP2013/066530 WO2014023757A1 (en) 2012-08-08 2013-08-07 Combinations with a backbone-cyclized peptide

Publications (2)

Publication Number Publication Date
EA201590351A1 true EA201590351A1 (ru) 2016-05-31
EA030077B1 EA030077B1 (ru) 2018-06-29

Family

ID=46796226

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590351A EA030077B1 (ru) 2012-08-08 2013-08-07 КОМБИНАЦИЯ, СОДЕРЖАЩАЯ β-ШПИЛЕЧНЫЙ ПЕПТИДОМИМЕТИК И ТИГЕЦИКЛИН, ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИЙ, ВЫЗВАННЫХ PSEUDOMONAS AERUGINOSA, И ЕЕ ПРИМЕНЕНИЕ

Country Status (26)

Country Link
US (1) US9775877B2 (ru)
EP (1) EP2882770B1 (ru)
JP (2) JP6486270B2 (ru)
KR (1) KR102167324B1 (ru)
CN (1) CN104684925B (ru)
AU (1) AU2013301567B2 (ru)
BR (1) BR112015002727B1 (ru)
CA (1) CA2879207C (ru)
CY (1) CY1119308T1 (ru)
DK (1) DK2882770T3 (ru)
EA (1) EA030077B1 (ru)
ES (1) ES2639165T3 (ru)
HK (1) HK1207866A1 (ru)
HR (1) HRP20171299T1 (ru)
HU (1) HUE035891T2 (ru)
IL (1) IL236697B (ru)
LT (1) LT2882770T (ru)
MX (2) MX366997B (ru)
NZ (1) NZ703729A (ru)
PL (1) PL2882770T3 (ru)
PT (1) PT2882770T (ru)
RS (1) RS56249B1 (ru)
SG (1) SG11201500216TA (ru)
SI (1) SI2882770T1 (ru)
WO (1) WO2014023757A1 (ru)
ZA (1) ZA201500278B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008104090A1 (en) 2007-02-28 2008-09-04 Polyphor Ag Template-fixed peptidomimetics
ES2639165T3 (es) * 2012-08-08 2017-10-25 Polyphor Ag Combinaciones con un péptido de esqueleto ciclado
IL303021A (en) * 2020-11-23 2023-07-01 Spexis Ag Peptidomimetic beta-herpain compositions and spray dosage forms thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070547A1 (en) 2001-02-23 2002-09-12 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
AU2002342618C1 (en) 2002-08-20 2008-10-30 Polyphor Ltd. Template-fixed peptidomimetics with antibacterial activity
WO2007079597A1 (en) * 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
WO2008104090A1 (en) * 2007-02-28 2008-09-04 Polyphor Ag Template-fixed peptidomimetics
US20100035845A1 (en) * 2008-08-06 2010-02-11 Wyeth Tigecycline formulations
ES2639165T3 (es) * 2012-08-08 2017-10-25 Polyphor Ag Combinaciones con un péptido de esqueleto ciclado

Also Published As

Publication number Publication date
US9775877B2 (en) 2017-10-03
EP2882770B1 (en) 2017-05-31
NZ703729A (en) 2018-03-23
EA030077B1 (ru) 2018-06-29
PT2882770T (pt) 2017-09-11
CY1119308T1 (el) 2018-02-14
IL236697B (en) 2020-02-27
HRP20171299T1 (hr) 2017-10-20
BR112015002727B1 (pt) 2022-09-06
ES2639165T3 (es) 2017-10-25
JP6486270B2 (ja) 2019-03-20
HUE035891T2 (en) 2018-05-28
CN104684925A (zh) 2015-06-03
AU2013301567A1 (en) 2015-02-05
WO2014023757A1 (en) 2014-02-13
CN104684925B (zh) 2021-11-30
LT2882770T (lt) 2017-10-10
US20150216927A1 (en) 2015-08-06
CA2879207A1 (en) 2014-02-13
EP2882770A1 (en) 2015-06-17
MX2019002657A (es) 2019-07-15
KR20150038612A (ko) 2015-04-08
IL236697A0 (en) 2015-02-26
DK2882770T3 (en) 2017-09-18
HK1207866A1 (en) 2016-02-12
SI2882770T1 (sl) 2017-10-30
PL2882770T3 (pl) 2018-01-31
ZA201500278B (en) 2016-01-27
KR102167324B1 (ko) 2020-10-20
MX366997B (es) 2019-08-02
JP2018087191A (ja) 2018-06-07
RS56249B1 (sr) 2017-11-30
JP2015524460A (ja) 2015-08-24
SG11201500216TA (en) 2015-03-30
MX2015001685A (es) 2015-04-10
AU2013301567B2 (en) 2017-08-03
CA2879207C (en) 2021-02-16
BR112015002727A2 (pt) 2017-08-08

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