EA201401271A1 - Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано[3,4,b]индол]-4-амин и антиконвульсант - Google Patents

Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано[3,4,b]индол]-4-амин и антиконвульсант

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Publication number
EA201401271A1
EA201401271A1 EA201401271A EA201401271A EA201401271A1 EA 201401271 A1 EA201401271 A1 EA 201401271A1 EA 201401271 A EA201401271 A EA 201401271A EA 201401271 A EA201401271 A EA 201401271A EA 201401271 A1 EA201401271 A1 EA 201401271A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diamide
spiro
dihydro
fluoro
dimethyl
Prior art date
Application number
EA201401271A
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English (en)
Other versions
EA029767B1 (ru
Inventor
Штефани Фрош
Клаус Линц
Томас Кристоф
Original Assignee
Грюненталь Гмбх
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Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201401271A1 publication Critical patent/EA201401271A1/ru
Publication of EA029767B1 publication Critical patent/EA029767B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение относится к фармацевтической композиции, содержащей первый фармакологически активный ингредиент, выбранный из (1R,4R)-6'-фтор-N,N-диметил-4-фенил-4',9'-дигидро-3'Н-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амина и его физиологически приемлемых солей, и второй фармакологически активный ингредиент, который представляет собой антиконвульсант, выбранный из группы, которая включает ретигабин, ламотригин, лакосамид, леветирацетам, карбамазепин, сультиам, фенацемид, фельбамат, топирамат, фенетурид, бриварацетам, селектрацетам, зонисамид, стирипентол, бекламид, мексилетин, ральфинамид, метилфенобарбитал, фенобарбитал, примидон, барбексаклон, метарбитал, этотоин, фенитоин, амино(дифенилгидантоин) валериановую кислоту, мефенитоин, фосфенитоин, параметадион, триметадион, этадион, этосуксимид, фенсуксимид, месуксимид, клоназепам, лоразепам, диазепам, клобазам, окскарбазепин, эсликарбазепин, руфинамид, вальпроевую кислоту, вальпромид, аминомасляную кислоту, прогабид, тиагабин, и их физиологически приемлемые соли.
EA201401271A 2012-05-18 2013-05-16 ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ (1r,4r)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО -3'H-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН И АНТИКОНВУЛЬСАНТ EA029767B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003898 2012-05-18
EP13159330 2013-03-15
PCT/EP2013/001471 WO2013170972A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and an anticonvulsant

Publications (2)

Publication Number Publication Date
EA201401271A1 true EA201401271A1 (ru) 2015-05-29
EA029767B1 EA029767B1 (ru) 2018-05-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201401271A EA029767B1 (ru) 2012-05-18 2013-05-16 ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ (1r,4r)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО -3'H-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН И АНТИКОНВУЛЬСАНТ

Country Status (21)

Country Link
US (1) US9345689B2 (ru)
EP (1) EP2852384B1 (ru)
JP (1) JP6116679B2 (ru)
CN (1) CN104284656A (ru)
AU (1) AU2013262078B2 (ru)
CA (1) CA2873871A1 (ru)
CY (1) CY1118634T1 (ru)
DK (1) DK2852384T3 (ru)
EA (1) EA029767B1 (ru)
ES (1) ES2624220T3 (ru)
HK (1) HK1204937A1 (ru)
HR (1) HRP20170517T1 (ru)
HU (1) HUE031984T2 (ru)
IL (1) IL235654A (ru)
LT (1) LT2852384T (ru)
MX (1) MX353177B (ru)
PL (1) PL2852384T3 (ru)
PT (1) PT2852384T (ru)
RS (1) RS55905B1 (ru)
SI (1) SI2852384T1 (ru)
WO (1) WO2013170972A1 (ru)

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EP3419621A4 (en) * 2016-02-26 2019-10-30 The Johns Hopkins University PHARMACOLOGICAL MODULATORS OF NAV1.1 VOLTAGE-CONTROLLED SODIUM CHANNELS ASSOCIATED WITH MECHANICAL PAIN
US20190125725A1 (en) * 2016-05-12 2019-05-02 Jubilant Generics Limited Pharmaceutical compositions comprising brivaracetam
AU2017371467B2 (en) * 2016-12-06 2023-06-01 Jan Marius KEPPEL HESSELINK Topical phenytoin for use in the treatment of peripheral neuropathic pain
EP3826610A4 (en) * 2018-07-24 2022-05-04 Zenvision Pharma LLP SYSTEM FOR NASAL DRUG DELIVERY OF BRIVARACETAM OR A SALT THEREOF

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Also Published As

Publication number Publication date
JP6116679B2 (ja) 2017-04-19
HK1204937A1 (en) 2015-12-11
MX353177B (es) 2018-01-05
CY1118634T1 (el) 2017-07-12
HUE031984T2 (en) 2017-08-28
LT2852384T (lt) 2017-04-25
DK2852384T3 (en) 2017-05-08
CN104284656A (zh) 2015-01-14
AU2013262078A1 (en) 2015-01-22
ES2624220T3 (es) 2017-07-13
EP2852384B1 (en) 2017-02-01
WO2013170972A1 (en) 2013-11-21
MX2014013179A (es) 2015-01-19
PL2852384T3 (pl) 2017-09-29
HRP20170517T1 (hr) 2017-06-02
CA2873871A1 (en) 2013-11-21
EA029767B1 (ru) 2018-05-31
PT2852384T (pt) 2017-05-10
EP2852384A1 (en) 2015-04-01
IL235654A (en) 2017-07-31
SI2852384T1 (sl) 2017-04-26
IL235654A0 (en) 2015-01-29
RS55905B1 (sr) 2017-09-29
AU2013262078B2 (en) 2017-10-26
US20130317009A1 (en) 2013-11-28
US9345689B2 (en) 2016-05-24
JP2015516452A (ja) 2015-06-11

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