EA201391790A1 - Очистка prame - Google Patents
Очистка prameInfo
- Publication number
- EA201391790A1 EA201391790A1 EA201391790A EA201391790A EA201391790A1 EA 201391790 A1 EA201391790 A1 EA 201391790A1 EA 201391790 A EA201391790 A EA 201391790A EA 201391790 A EA201391790 A EA 201391790A EA 201391790 A1 EA201391790 A1 EA 201391790A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diluent
- prame
- clean
- replacing
- relates
- Prior art date
Links
- 102000036673 PRAME Human genes 0.000 title abstract 3
- 108060006580 PRAME Proteins 0.000 title abstract 3
- 239000003085 diluting agent Substances 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001189—PRAME
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
Abstract
Настоящее изобретение относится к способам очистки PRAME. В частности, настоящее изобретение относится к способу снижения агрегации PRAME при замене разбавителя А на разбавитель В, включающему: (1) добавление полианионного соединения к разбавителю А до или одновременно с заменой и (2) перенос белка из разбавителя А в разбавитель В. Также предложены композиции, приготовленные посредством этого способа.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1112658.8A GB201112658D0 (en) | 2011-07-22 | 2011-07-22 | Prame purification |
GBGB1115737.7A GB201115737D0 (en) | 2011-09-12 | 2011-09-12 | Prame purification |
PCT/EP2012/064340 WO2013014105A1 (en) | 2011-07-22 | 2012-07-20 | Prame purification |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201391790A1 true EA201391790A1 (ru) | 2014-06-30 |
Family
ID=46551555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201391790A EA201391790A1 (ru) | 2011-07-22 | 2012-07-20 | Очистка prame |
Country Status (12)
Country | Link |
---|---|
US (1) | US20140234424A1 (ru) |
EP (1) | EP2734539A1 (ru) |
JP (1) | JP2014529338A (ru) |
KR (1) | KR20140049569A (ru) |
CN (1) | CN103717613A (ru) |
AU (1) | AU2012288926A1 (ru) |
BR (1) | BR112014001052A2 (ru) |
CA (1) | CA2841380A1 (ru) |
EA (1) | EA201391790A1 (ru) |
MX (1) | MX2014000893A (ru) |
WO (1) | WO2013014105A1 (ru) |
ZA (1) | ZA201400061B (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
BR112020011443A2 (pt) * | 2017-12-13 | 2020-12-01 | Inovio Pharmaceuticals, Inc. | molécula de ácido nucleico e seu uso, vetor e seu uso, composição, proteína e vacina |
CN113278064B (zh) * | 2021-07-20 | 2021-11-02 | 山东信得科技股份有限公司 | 一种用于胚毒类抗原净化处理的方法及其应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
EP0468520A3 (en) | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
US5830753A (en) | 1994-09-30 | 1998-11-03 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof. |
GB0411411D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxosmithkline Biolog Sa | Vaccines |
TWI434697B (zh) | 2007-01-15 | 2014-04-21 | Glaxosmithkline Biolog Sa | 疫苗 |
CA2687632C (en) * | 2007-05-24 | 2013-01-15 | Glaxosmithkline Biologicals S.A. | Lyophilised antigen composition |
GB0910045D0 (en) * | 2009-06-10 | 2009-07-22 | Glaxosmithkline Biolog Sa | Novel compositions |
-
2012
- 2012-07-20 EA EA201391790A patent/EA201391790A1/ru unknown
- 2012-07-20 US US14/234,111 patent/US20140234424A1/en not_active Abandoned
- 2012-07-20 CA CA2841380A patent/CA2841380A1/en not_active Abandoned
- 2012-07-20 MX MX2014000893A patent/MX2014000893A/es unknown
- 2012-07-20 BR BR112014001052A patent/BR112014001052A2/pt not_active IP Right Cessation
- 2012-07-20 EP EP12738119.2A patent/EP2734539A1/en not_active Withdrawn
- 2012-07-20 AU AU2012288926A patent/AU2012288926A1/en not_active Abandoned
- 2012-07-20 CN CN201280036131.4A patent/CN103717613A/zh active Pending
- 2012-07-20 WO PCT/EP2012/064340 patent/WO2013014105A1/en active Application Filing
- 2012-07-20 JP JP2014520681A patent/JP2014529338A/ja active Pending
- 2012-07-20 KR KR1020147004616A patent/KR20140049569A/ko not_active Application Discontinuation
-
2014
- 2014-01-06 ZA ZA2014/00061A patent/ZA201400061B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2013014105A1 (en) | 2013-01-31 |
KR20140049569A (ko) | 2014-04-25 |
EP2734539A1 (en) | 2014-05-28 |
MX2014000893A (es) | 2014-05-30 |
BR112014001052A2 (pt) | 2017-02-21 |
US20140234424A1 (en) | 2014-08-21 |
AU2012288926A1 (en) | 2014-01-16 |
CA2841380A1 (en) | 2013-01-31 |
CN103717613A (zh) | 2014-04-09 |
ZA201400061B (en) | 2017-08-30 |
JP2014529338A (ja) | 2014-11-06 |
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