EA201300389A1 - Оксадиазольные ингибиторы продуцирования лейкотриена - Google Patents
Оксадиазольные ингибиторы продуцирования лейкотриенаInfo
- Publication number
- EA201300389A1 EA201300389A1 EA201300389A EA201300389A EA201300389A1 EA 201300389 A1 EA201300389 A1 EA 201300389A1 EA 201300389 A EA201300389 A EA 201300389A EA 201300389 A EA201300389 A EA 201300389A EA 201300389 A1 EA201300389 A1 EA 201300389A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- leukotrien
- oxadiazol
- inhibitors
- production
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38573310P | 2010-09-23 | 2010-09-23 | |
| US201161533349P | 2011-09-12 | 2011-09-12 | |
| PCT/US2011/052254 WO2012040139A1 (en) | 2010-09-23 | 2011-09-20 | Oxadiazole inhibitors of leukotriene production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201300389A1 true EA201300389A1 (ru) | 2013-09-30 |
Family
ID=44720163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201300389A EA201300389A1 (ru) | 2010-09-23 | 2011-09-20 | Оксадиазольные ингибиторы продуцирования лейкотриена |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8575201B2 (enExample) |
| EP (1) | EP2619197B1 (enExample) |
| JP (1) | JP5713511B2 (enExample) |
| KR (1) | KR20130109122A (enExample) |
| CN (1) | CN103261193A (enExample) |
| AU (1) | AU2011305667A1 (enExample) |
| BR (1) | BR112013008638A2 (enExample) |
| CA (1) | CA2812449A1 (enExample) |
| CL (1) | CL2013000788A1 (enExample) |
| CO (1) | CO6710902A2 (enExample) |
| EA (1) | EA201300389A1 (enExample) |
| EC (1) | ECSP13012548A (enExample) |
| IN (1) | IN2013DN02555A (enExample) |
| MX (1) | MX2013003202A (enExample) |
| PE (1) | PE20131398A1 (enExample) |
| PH (1) | PH12013500545A1 (enExample) |
| SG (1) | SG188604A1 (enExample) |
| WO (1) | WO2012040139A1 (enExample) |
| ZA (1) | ZA201301747B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3150164B2 (ja) | 1991-05-01 | 2001-03-26 | 電気化学工業株式会社 | セメント混和材及びセメント組成物 |
| EP2609092B1 (en) * | 2010-08-26 | 2015-04-01 | Boehringer Ingelheim International GmbH | Oxadiazole inhibitors of leukotriene production |
| EP2619197B1 (en) | 2010-09-23 | 2015-08-05 | Boehringer Ingelheim International GmbH | Oxadiazole inhibitors of leukotriene production |
| JP5828188B2 (ja) * | 2010-09-23 | 2015-12-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害剤 |
| AR089853A1 (es) | 2012-02-01 | 2014-09-24 | Boehringer Ingelheim Int | Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso |
| US9745328B2 (en) * | 2013-02-04 | 2017-08-29 | Janssen Pharmaceutica Nv | Flap modulators |
| EP2875736B1 (en) | 2013-11-26 | 2016-07-27 | Citrage | N-Carbamoylputrescine to enhance muscle protein synthesis |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE318811T1 (de) | 1999-08-06 | 2006-03-15 | Janssen Pharmaceutica Nv | Interleukin-5 hemmende 6-azauracil derivate |
| US20050054663A1 (en) * | 2003-08-13 | 2005-03-10 | Bennett Christina N. | GSK-3 inhibitors |
| US7319108B2 (en) | 2004-01-25 | 2008-01-15 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted heterocycles, process for their preparation and their use as medicaments |
| WO2006044602A2 (en) | 2004-10-18 | 2006-04-27 | Merck & Co., Inc. | Diphenyl substituted alkanes as flap inhiibitors |
| US7977359B2 (en) * | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) * | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| CN101466677A (zh) | 2006-04-11 | 2009-06-24 | 默克公司 | 二芳基取代的烷烃 |
| US20080096900A1 (en) | 2006-06-26 | 2008-04-24 | Amgen Inc. | Methods for treating atherosclerosis |
| ATE543810T1 (de) * | 2006-09-01 | 2012-02-15 | Merck Sharp & Dohme | Hemmer des 5-lipoxygenase aktivierenden proteins (flap) |
| EP2148878A4 (en) | 2007-04-20 | 2011-08-10 | Merck Canada Inc | NEW HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME-A-DELTA-9-DESATURASE |
| EP2546232A1 (en) | 2007-06-20 | 2013-01-16 | Merck Sharp & Dohme Corp. | Diphenyl Substituted Alkanes |
| JP2011500563A (ja) | 2007-10-10 | 2011-01-06 | メルク・シャープ・エンド・ドーム・コーポレイション | ジフェニル置換されたシクロアルカン |
| DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| US8598209B2 (en) * | 2008-10-31 | 2013-12-03 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| TW201040175A (en) | 2009-02-04 | 2010-11-16 | Pfizer | 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one derivatives |
| SG185414A1 (en) | 2010-05-12 | 2012-12-28 | Univ Vanderbilt | Heterocyclic sulfone mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| BR112013003439A2 (pt) * | 2010-08-16 | 2019-09-24 | Boehringer Ingelheim Int | "inibidores de oxadiazol de produção de leucotrieno" |
| EP2609092B1 (en) * | 2010-08-26 | 2015-04-01 | Boehringer Ingelheim International GmbH | Oxadiazole inhibitors of leukotriene production |
| EP2619197B1 (en) | 2010-09-23 | 2015-08-05 | Boehringer Ingelheim International GmbH | Oxadiazole inhibitors of leukotriene production |
| JP5828188B2 (ja) * | 2010-09-23 | 2015-12-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害剤 |
-
2011
- 2011-09-20 EP EP11761775.3A patent/EP2619197B1/en active Active
- 2011-09-20 BR BR112013008638A patent/BR112013008638A2/pt not_active IP Right Cessation
- 2011-09-20 KR KR1020137007287A patent/KR20130109122A/ko not_active Withdrawn
- 2011-09-20 US US13/237,112 patent/US8575201B2/en active Active
- 2011-09-20 IN IN2555DEN2013 patent/IN2013DN02555A/en unknown
- 2011-09-20 CA CA2812449A patent/CA2812449A1/en not_active Abandoned
- 2011-09-20 CN CN2011800565586A patent/CN103261193A/zh active Pending
- 2011-09-20 EA EA201300389A patent/EA201300389A1/ru unknown
- 2011-09-20 JP JP2013530221A patent/JP5713511B2/ja active Active
- 2011-09-20 MX MX2013003202A patent/MX2013003202A/es active IP Right Grant
- 2011-09-20 PE PE2013000629A patent/PE20131398A1/es not_active Application Discontinuation
- 2011-09-20 AU AU2011305667A patent/AU2011305667A1/en not_active Abandoned
- 2011-09-20 PH PH1/2013/500545A patent/PH12013500545A1/en unknown
- 2011-09-20 SG SG2013020300A patent/SG188604A1/en unknown
- 2011-09-20 WO PCT/US2011/052254 patent/WO2012040139A1/en not_active Ceased
-
2013
- 2013-03-07 ZA ZA2013/01747A patent/ZA201301747B/en unknown
- 2013-03-21 CL CL2013000788A patent/CL2013000788A1/es unknown
- 2013-03-22 CO CO13057875A patent/CO6710902A2/es not_active Application Discontinuation
- 2013-04-11 EC ECSP13012548 patent/ECSP13012548A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IN2013DN02555A (enExample) | 2015-08-07 |
| PE20131398A1 (es) | 2013-12-19 |
| ECSP13012548A (es) | 2013-06-28 |
| CO6710902A2 (es) | 2013-07-15 |
| WO2012040139A1 (en) | 2012-03-29 |
| MX2013003202A (es) | 2013-04-24 |
| US8575201B2 (en) | 2013-11-05 |
| EP2619197B1 (en) | 2015-08-05 |
| CL2013000788A1 (es) | 2013-06-28 |
| PH12013500545A1 (en) | 2013-05-06 |
| JP2013537909A (ja) | 2013-10-07 |
| CA2812449A1 (en) | 2012-03-29 |
| US20120295896A1 (en) | 2012-11-22 |
| EP2619197A1 (en) | 2013-07-31 |
| JP5713511B2 (ja) | 2015-05-07 |
| AU2011305667A1 (en) | 2013-03-21 |
| KR20130109122A (ko) | 2013-10-07 |
| BR112013008638A2 (pt) | 2016-06-21 |
| CN103261193A (zh) | 2013-08-21 |
| SG188604A1 (en) | 2013-04-30 |
| ZA201301747B (en) | 2014-08-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201300250A1 (ru) | Оксадиазольные ингибиторы продуцирования лейкотриена | |
| EA201500298A1 (ru) | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы | |
| EA201301019A1 (ru) | Бензодиоксановые ингибиторы продуцирования лейкотриена | |
| EA201270492A1 (ru) | Соединения для лечения дислипидемии и связанных с ней заболеваний | |
| UA111770C2 (uk) | Інгібітори бромдомену | |
| EA201370166A1 (ru) | Содержащие диарилацетиленгидразид ингибиторы тирозинкиназы | |
| UA111841C2 (uk) | Сполуки бензотіазолу та їх фармацевтичне застосування | |
| EA201491012A1 (ru) | Гетероциклические ингибиторы глютаминазы | |
| EA201591195A1 (ru) | Новые хинолоновые производные | |
| EA201391532A1 (ru) | Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов | |
| EA201491672A1 (ru) | Гетероциклильные соединения как ингибиторы mek | |
| EA201590975A1 (ru) | Ингибиторы prmt5 и их применение | |
| EA201500278A1 (ru) | Пиразолилхиназолиновые ингибиторы киназы | |
| EA201490471A1 (ru) | Пиридазиноновые соединения и их применение в качестве ингибиторов daao | |
| EA201490272A1 (ru) | Новые 4-пиперидинильные соединения для применения в качестве ингибиторов танкиразы | |
| EA201490888A1 (ru) | Новые производные пурина и их применение для лечения заболевания | |
| EA201301181A1 (ru) | Триазолопиридины | |
| AU2011286276A8 (en) | Substituted Biphenylene Compounds and methods of use thereof for the treatment of viral diseases | |
| EA201390579A1 (ru) | Производные хиназолин-4(3h)-она, используемые как ингибиторы pi3-киназы | |
| EA201491028A1 (ru) | Способ получения замещенных 5-фтор-1н-пиразолопиридинов | |
| EA201101533A1 (ru) | Гетероциклические соединения в качестве ингибиторов mek | |
| EA201390984A1 (ru) | Гетероциклические соединения, подходящие для лечения дислипидемии | |
| NZ706591A (en) | Oxazolidin-2-one-pyrimidine derivatives | |
| EA201300389A1 (ru) | Оксадиазольные ингибиторы продуцирования лейкотриена | |
| EA201790253A1 (ru) | Ингибиторы альдостеронсинтазы |