PE20131398A1 - Inhibidores de oxadiazol de la produccion de leucotrienos - Google Patents
Inhibidores de oxadiazol de la produccion de leucotrienosInfo
- Publication number
- PE20131398A1 PE20131398A1 PE2013000629A PE2013000629A PE20131398A1 PE 20131398 A1 PE20131398 A1 PE 20131398A1 PE 2013000629 A PE2013000629 A PE 2013000629A PE 2013000629 A PE2013000629 A PE 2013000629A PE 20131398 A1 PE20131398 A1 PE 20131398A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridin
- oxadiazol
- alkyl
- compounds
- cyclobutil
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE OXADIAZOL DE FORMULA (I) DONDE R1 Y R2 JUNTO CON EL ATOMO DE CARBONO A LOS QUE SE UNEN FORMAN UN ANILLO CARBOCICLICO(C3-C10) O UN ANILLO HETEROCICLICO DE 5 A 11 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON ALQUILO(C1-C6) O HALOGENO; R3 ES HETEROARILO DE 5 A 11 MIEMBROS OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C5), CN, AMINO, ENTRE OTROS; R4 ES H, HALOGENO, ALQUILO(C1-C3) O NITRILO; R5 ES ALQUILO(C1-C6), ARILO, HETEROARILO DE 5 A 11 MIEMBROS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-[5-(3-{1-[6-(2-AMINOPIRIMIDIN-5-IL)PIRIDIN-3-IL]CICLOBUTIL}-1,2,4-OXADIAZOL-5-IL)PIRIDIN-2-IL]PIPERAZIN-1-CARBOXILATO DE TER-BUTILO; N-2-[5-(3-{1-[6-(2-AMINOPIRIMIDIN-5-IL)PIRIDIN-3-IL]CICLOBUTIL}-1,2,4-OXADIAZOL-5-IL)PIRIDIN-2-IL]GLICINAMIDA; 5-[5-(1-{5-[6-(PIPERAZIN-1-IL)PIRIDIN-3-IL]-1,2,4-OXADIAZOL-3-IL}CICLOBUTIL)PIRIDIN-2-IL] PIRIMIDIN-2-AMINA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA ACTIVADORA DE LA 5-LIPOXIGENASA (FLAP) SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS MEDIADOS POR LEUCOTRIENOS TALES COMO ATEROSCLEROSIS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38573310P | 2010-09-23 | 2010-09-23 | |
US201161533349P | 2011-09-12 | 2011-09-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20131398A1 true PE20131398A1 (es) | 2013-12-19 |
Family
ID=44720163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013000629A PE20131398A1 (es) | 2010-09-23 | 2011-09-20 | Inhibidores de oxadiazol de la produccion de leucotrienos |
Country Status (18)
Country | Link |
---|---|
US (1) | US8575201B2 (es) |
EP (1) | EP2619197B1 (es) |
JP (1) | JP5713511B2 (es) |
KR (1) | KR20130109122A (es) |
CN (1) | CN103261193A (es) |
AU (1) | AU2011305667A1 (es) |
BR (1) | BR112013008638A2 (es) |
CA (1) | CA2812449A1 (es) |
CL (1) | CL2013000788A1 (es) |
CO (1) | CO6710902A2 (es) |
EA (1) | EA201300389A1 (es) |
EC (1) | ECSP13012548A (es) |
IN (1) | IN2013DN02555A (es) |
MX (1) | MX2013003202A (es) |
PE (1) | PE20131398A1 (es) |
SG (1) | SG188604A1 (es) |
WO (1) | WO2012040139A1 (es) |
ZA (1) | ZA201301747B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012027322A1 (en) * | 2010-08-26 | 2012-03-01 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
JP5828188B2 (ja) * | 2010-09-23 | 2015-12-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害剤 |
WO2012040139A1 (en) | 2010-09-23 | 2012-03-29 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
AR089853A1 (es) | 2012-02-01 | 2014-09-24 | Boehringer Ingelheim Int | Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso |
US9745328B2 (en) * | 2013-02-04 | 2017-08-29 | Janssen Pharmaceutica Nv | Flap modulators |
EP2875736B1 (en) | 2013-11-26 | 2016-07-27 | Citrage | N-Carbamoylputrescine to enhance muscle protein synthesis |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60026312T2 (de) | 1999-08-06 | 2006-12-21 | Janssen Pharmaceutica N.V. | Interleukin-5 hemmende 6-azauracil derivate |
WO2005039485A2 (en) * | 2003-08-13 | 2005-05-06 | Chiron Corporation | Gsk-3 inhibitors and uses thereof |
US7319108B2 (en) | 2004-01-25 | 2008-01-15 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted heterocycles, process for their preparation and their use as medicaments |
CA2584262A1 (en) | 2004-10-18 | 2006-04-27 | Merck & Co., Inc. | Diphenyl substituted alkanes as flap inhiibitors |
GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
US8399666B2 (en) * | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
AU2007238878A1 (en) * | 2006-04-11 | 2007-10-25 | Merck Sharp & Dohme Corp. | Diaryl substituted alkanes |
ES2376396T3 (es) | 2006-06-26 | 2012-03-13 | Amgen Inc. | Método para tratar aterosclerosis. |
ATE543810T1 (de) * | 2006-09-01 | 2012-02-15 | Merck Sharp & Dohme | Hemmer des 5-lipoxygenase aktivierenden proteins (flap) |
EP2148878A4 (en) | 2007-04-20 | 2011-08-10 | Merck Canada Inc | NEW HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME-A-DELTA-9-DESATURASE |
WO2008156721A1 (en) | 2007-06-20 | 2008-12-24 | Merck & Co., Inc. | Diphenyl substituted alkanes |
CA2702225A1 (en) | 2007-10-10 | 2009-04-16 | Merck Sharp & Dohme Corp. | Diphenyl substituted cycloalkanes |
DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
CA2741666C (en) * | 2008-10-31 | 2017-04-11 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
CA2749893A1 (en) | 2009-02-04 | 2010-08-12 | Pfizer Inc. | 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives |
MX2012013031A (es) | 2010-05-12 | 2012-12-17 | Univ Vanderbilt | Potenciadores alostericos mglur4 de sulfona heterociclica, composiciones y metodos para tratar disfuncion neurologica. |
SG187549A1 (en) * | 2010-08-16 | 2013-03-28 | Boehringer Ingelheim Int | Oxadiazole inhibitors of leukotriene production |
WO2012027322A1 (en) * | 2010-08-26 | 2012-03-01 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
WO2012040139A1 (en) | 2010-09-23 | 2012-03-29 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
JP5828188B2 (ja) * | 2010-09-23 | 2015-12-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン産生のオキサジアゾール阻害剤 |
-
2011
- 2011-09-20 WO PCT/US2011/052254 patent/WO2012040139A1/en active Application Filing
- 2011-09-20 PE PE2013000629A patent/PE20131398A1/es not_active Application Discontinuation
- 2011-09-20 CA CA2812449A patent/CA2812449A1/en not_active Abandoned
- 2011-09-20 JP JP2013530221A patent/JP5713511B2/ja active Active
- 2011-09-20 US US13/237,112 patent/US8575201B2/en active Active
- 2011-09-20 EA EA201300389A patent/EA201300389A1/ru unknown
- 2011-09-20 IN IN2555DEN2013 patent/IN2013DN02555A/en unknown
- 2011-09-20 MX MX2013003202A patent/MX2013003202A/es active IP Right Grant
- 2011-09-20 SG SG2013020300A patent/SG188604A1/en unknown
- 2011-09-20 BR BR112013008638A patent/BR112013008638A2/pt not_active IP Right Cessation
- 2011-09-20 EP EP11761775.3A patent/EP2619197B1/en active Active
- 2011-09-20 AU AU2011305667A patent/AU2011305667A1/en not_active Abandoned
- 2011-09-20 CN CN2011800565586A patent/CN103261193A/zh active Pending
- 2011-09-20 KR KR1020137007287A patent/KR20130109122A/ko not_active Application Discontinuation
-
2013
- 2013-03-07 ZA ZA2013/01747A patent/ZA201301747B/en unknown
- 2013-03-21 CL CL2013000788A patent/CL2013000788A1/es unknown
- 2013-03-22 CO CO13057875A patent/CO6710902A2/es not_active Application Discontinuation
- 2013-04-11 EC ECSP13012548 patent/ECSP13012548A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2013003202A (es) | 2013-04-24 |
KR20130109122A (ko) | 2013-10-07 |
JP5713511B2 (ja) | 2015-05-07 |
EP2619197A1 (en) | 2013-07-31 |
CL2013000788A1 (es) | 2013-06-28 |
CN103261193A (zh) | 2013-08-21 |
SG188604A1 (en) | 2013-04-30 |
EA201300389A1 (ru) | 2013-09-30 |
WO2012040139A1 (en) | 2012-03-29 |
ECSP13012548A (es) | 2013-06-28 |
ZA201301747B (en) | 2014-08-27 |
US8575201B2 (en) | 2013-11-05 |
JP2013537909A (ja) | 2013-10-07 |
CO6710902A2 (es) | 2013-07-15 |
IN2013DN02555A (es) | 2015-08-07 |
EP2619197B1 (en) | 2015-08-05 |
CA2812449A1 (en) | 2012-03-29 |
BR112013008638A2 (pt) | 2016-06-21 |
US20120295896A1 (en) | 2012-11-22 |
AU2011305667A1 (en) | 2013-03-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |