EA201291469A1 - Новые ингибиторы протеазы - катепсина s, предназначенные для лечения, в частности, аутоиммунных расстройств, аллергии и состояний хронической боли - Google Patents

Новые ингибиторы протеазы - катепсина s, предназначенные для лечения, в частности, аутоиммунных расстройств, аллергии и состояний хронической боли

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EA201291469A1
EA201291469A1 EA201291469A EA201291469A EA201291469A1 EA 201291469 A1 EA201291469 A1 EA 201291469A1 EA 201291469 A EA201291469 A EA 201291469A EA 201291469 A EA201291469 A EA 201291469A EA 201291469 A1 EA201291469 A1 EA 201291469A1
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Eurasian Patent Office
Prior art keywords
alkoxy
alkyl
haloalkyl
katepsin
allergy
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EA201291469A
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English (en)
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Сусана Айеса
Урсула Грабовска
Эллен Хьюитт
Даниель Йенссон
Бьерн Классон
Пиа Канберг
Стина Лундгрен
Ян Тейбрант
Даниель Виктелиус
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МЕДИВИР ЮКей ЛИМИТЕД
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Publication of EA201291469A1 publication Critical patent/EA201291469A1/ru

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Abstract

Соединение формулы (I), где Rи Rнезависимо обозначают Н, атом галогена, С-Салкил, С-Сгалогеналкил или С-Салкокси или же Rи Rвместе с атомом углерода, к которому они присоединены, образуют С-Сциклоалкил; Rобозначает С-Салкил, необязательно замещенный 1-3 заместителями, независимо выбранными из атома галогена, С-Сгалогеналкила, С-Салкокси, С-Сгалогеналкокси; или Rобозначает C-Салкильную цепь, содержащую в качестве заместителей по меньшей мере 2 атома хлора или 3 атома фтора; или Rобозначает С-Сциклоалкилметил, необязательно замещенный 1-3 заместителями, независимо выбранными из C-Салкила, атома галогена, С-Сгалогеналкила, С-Салкокси, C-Сгалогеналкокси; Rобозначает С-Салкил, C-Сгалогеналкил, С-Салкокси, С-Сгалогеналкокси, C-Салкиламино, С-Сциалкиламино; или Rобозначает Het или карбоциклил, любой из которых необязательно замещен 1-3 заместителями; n принимает значение 1, 2 или 3; для применения для профилактики или лечения расстройства, которое характеризуется отклоняющейся от нормы экспрессией или активацией катепсина S.
EA201291469A 2010-06-16 2011-06-16 Новые ингибиторы протеазы - катепсина s, предназначенные для лечения, в частности, аутоиммунных расстройств, аллергии и состояний хронической боли EA201291469A1 (ru)

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SE1050618 2010-06-16
PCT/IB2011/052613 WO2011158197A1 (en) 2010-06-16 2011-06-16 New cathepsin s protease inhibitors, useful in the treatment of e.g. autoimmune disorders, allergy and chronic pain conditions

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PH12014501958A1 (en) 2015-09-21
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