EA201290822A1 - Триазолоны в качестве ингибиторов синтазы жирных кислот - Google Patents
Триазолоны в качестве ингибиторов синтазы жирных кислотInfo
- Publication number
- EA201290822A1 EA201290822A1 EA201290822A EA201290822A EA201290822A1 EA 201290822 A1 EA201290822 A1 EA 201290822A1 EA 201290822 A EA201290822 A EA 201290822A EA 201290822 A EA201290822 A EA 201290822A EA 201290822 A1 EA201290822 A1 EA 201290822A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- triazolones
- fatty acids
- synthase inhibitors
- acids synthase
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30670910P | 2010-02-22 | 2010-02-22 | |
| US35758710P | 2010-06-23 | 2010-06-23 | |
| PCT/US2011/025661 WO2011103546A1 (en) | 2010-02-22 | 2011-02-22 | Triazolones as fatty acid synthase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201290822A1 true EA201290822A1 (ru) | 2013-03-29 |
Family
ID=44483349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201290822A EA201290822A1 (ru) | 2010-02-22 | 2011-02-22 | Триазолоны в качестве ингибиторов синтазы жирных кислот |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8802864B2 (enExample) |
| EP (1) | EP2538787B1 (enExample) |
| JP (1) | JP5805672B2 (enExample) |
| KR (1) | KR20120133386A (enExample) |
| CN (1) | CN102858175A (enExample) |
| AU (1) | AU2011217809A1 (enExample) |
| BR (1) | BR112012020976A2 (enExample) |
| CA (1) | CA2790692A1 (enExample) |
| EA (1) | EA201290822A1 (enExample) |
| ES (1) | ES2509951T3 (enExample) |
| MX (1) | MX2012009720A (enExample) |
| SG (1) | SG183260A1 (enExample) |
| WO (1) | WO2011103546A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011103546A1 (en) * | 2010-02-22 | 2011-08-25 | Glaxosmithkline Llc | Triazolones as fatty acid synthase inhibitors |
| US9505728B2 (en) | 2012-03-09 | 2016-11-29 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| EP2935228B9 (en) | 2012-12-20 | 2017-12-06 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| ES2651331T3 (es) * | 2013-01-10 | 2018-01-25 | Glaxosmithkline Intellectual Property (No. 2) Limited | Inhibidores de la sintasa de ácidos grasos |
| MY191366A (en) | 2013-03-13 | 2022-06-20 | Forma Therapeutics Inc | Novel compounds and compositions for inhibition of fasn |
| BR102014021960A2 (pt) | 2013-09-05 | 2015-09-15 | Univ Michigan State | métodos para a produção de arenos borilados |
| PE20160880A1 (es) | 2013-09-06 | 2016-09-22 | Inception 2 Inc | Compuestos de triazolona y usos de los mismos |
| EP3083600B1 (en) | 2013-12-17 | 2018-09-26 | Janssen Pharmaceutica NV | Imidazolin-5-one derivatives useful as fasn inhibitors for the treatment of cancer |
| TW201625354A (zh) | 2014-06-16 | 2016-07-16 | 陶氏農業科學公司 | 用於製備氧硼基化芳烴之方法 |
| CN104876917B (zh) * | 2015-06-16 | 2017-09-19 | 上海皓元医药股份有限公司 | 用作脂肪酸合成酶抑制剂的三唑酮的合成方法 |
| MX379846B (es) | 2015-06-18 | 2025-03-11 | 89Bio Ltd | Derivados de 4-bencil y 4-benzoil piperidina sustituidos. |
| AU2016280255A1 (en) | 2015-06-18 | 2018-02-08 | Cephalon, Inc. | 1, 4-substituted piperidine derivatives |
| TW201722957A (zh) * | 2015-09-15 | 2017-07-01 | 葛蘭素史克智慧財產（第二）有限公司 | 化學化合物 |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| US10793554B2 (en) | 2018-10-29 | 2020-10-06 | Forma Therapeutics, Inc. | Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
| CN114539193B (zh) * | 2022-01-20 | 2024-08-06 | 安徽普利药业有限公司 | 一种盐酸胺碘酮中间体的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728834A (en) * | 1996-11-14 | 1998-03-17 | Wyckoff Chemical Company, Inc. | Process for preparation of 4-aryl-1,2,4-triazol-3-ones |
| WO2004064730A2 (en) * | 2003-01-14 | 2004-08-05 | Cytokinetics, Inc. | Compounds, compositions and methods |
| SE0400850D0 (sv) * | 2004-03-30 | 2004-03-31 | Astrazeneca Ab | Novel Compounds |
| ATE492544T1 (de) * | 2004-08-26 | 2011-01-15 | Pfizer | Pyrazol-substituierte aminoheteroarylverbindungen als proteinkinasehemmer |
| JP5116687B2 (ja) * | 2005-11-02 | 2013-01-09 | バイエル・ファルマ・アクチェンゲゼルシャフト | がんおよび他の過剰増殖性疾患の処置のためのピロロ［２，１−ｆ］［１，２，４］トリアジン−４−イルアミンＩＧＦ−１Ｒキナーゼ阻害剤 |
| WO2009143153A1 (en) * | 2008-05-23 | 2009-11-26 | Janssen Pharmaceutica Nv | Substituted pyrrolidine amides as modulators of the histamine h3 receptor |
| WO2011103546A1 (en) * | 2010-02-22 | 2011-08-25 | Glaxosmithkline Llc | Triazolones as fatty acid synthase inhibitors |
-
2011
- 2011-02-22 WO PCT/US2011/025661 patent/WO2011103546A1/en not_active Ceased
- 2011-02-22 US US13/579,040 patent/US8802864B2/en not_active Expired - Fee Related
- 2011-02-22 SG SG2012059291A patent/SG183260A1/en unknown
- 2011-02-22 JP JP2012554085A patent/JP5805672B2/ja not_active Expired - Fee Related
- 2011-02-22 ES ES11745417.3T patent/ES2509951T3/es active Active
- 2011-02-22 EP EP11745417.3A patent/EP2538787B1/en active Active
- 2011-02-22 CA CA2790692A patent/CA2790692A1/en not_active Abandoned
- 2011-02-22 BR BR112012020976A patent/BR112012020976A2/pt not_active Application Discontinuation
- 2011-02-22 EA EA201290822A patent/EA201290822A1/ru unknown
- 2011-02-22 AU AU2011217809A patent/AU2011217809A1/en not_active Abandoned
- 2011-02-22 CN CN2011800201452A patent/CN102858175A/zh active Pending
- 2011-02-22 KR KR1020127024682A patent/KR20120133386A/ko not_active Withdrawn
- 2011-02-22 MX MX2012009720A patent/MX2012009720A/es unknown
-
2013
- 2013-11-04 US US14/071,093 patent/US9340529B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20140100213A1 (en) | 2014-04-10 |
| CA2790692A1 (en) | 2011-08-25 |
| KR20120133386A (ko) | 2012-12-10 |
| US8802864B2 (en) | 2014-08-12 |
| ES2509951T3 (es) | 2014-10-20 |
| CN102858175A (zh) | 2013-01-02 |
| EP2538787A1 (en) | 2013-01-02 |
| AU2011217809A1 (en) | 2012-09-06 |
| WO2011103546A1 (en) | 2011-08-25 |
| MX2012009720A (es) | 2012-10-09 |
| SG183260A1 (en) | 2012-09-27 |
| BR112012020976A2 (pt) | 2017-05-09 |
| US9340529B2 (en) | 2016-05-17 |
| EP2538787B1 (en) | 2014-07-16 |
| JP5805672B2 (ja) | 2015-11-04 |
| US20120316151A1 (en) | 2012-12-13 |
| JP2013520443A (ja) | 2013-06-06 |
| EP2538787A4 (en) | 2013-07-17 |
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