EA201201234A1 - Составной белок - Google Patents
Составной белокInfo
- Publication number
- EA201201234A1 EA201201234A1 EA201201234A EA201201234A EA201201234A1 EA 201201234 A1 EA201201234 A1 EA 201201234A1 EA 201201234 A EA201201234 A EA 201201234A EA 201201234 A EA201201234 A EA 201201234A EA 201201234 A1 EA201201234 A1 EA 201201234A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- nucleic acid
- acid molecule
- seq
- polypeptide
- sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Выделенная молекула нуклеиновой кислоты выбрана из группы, к которой относятся: vi) молекула нуклеиновой кислоты, включающая нуклеотидную последовательность, которая как минимум на 85% идентична нуклеотидной последовательности SEQ ID NO: 1 или ее комплемента; vii) молекула нуклеиновой кислоты, включающая фрагмент как минимум из 1500 последовательных нуклеотидов нуклеотидной последовательности SEQ ID NO: 1 или ее комплемента; viii) молекула нуклеиновой кислоты, кодирующей полипептид, включающий аминокислотную последовательность, как минимум на 85% идентичную SEQ ID NO: 2; ix) молекула нуклеиновой кислоты, которая кодирует фрагмент полипептида, включающего аминокислотную последовательность SEQ ID NO: 2, причем фрагмент включает как минимум 500 заменимых аминокислот SEQ ID NO: 2; и х) молекула нуклеиновой кислоты, кодирующей полипептид, включающий гуманизированный иммуноглобулин или части иммуноглобулина, имеющие специфичность связывания с CD 133 молекула нуклеиновой кислоты, которая кодирует вариант полипептида, включающего аминокислотную последовательность SEQ ID NO: 2, причем молекула нуклеиновой кислоты гибридизируется с молекулой нуклеиновой кислоты, включающей полную последовательность SEQ ID NO: 1 или ее комплемент, в условиях инкубации при 45°С в 6,0×SSC с последующим промыванием в 0,2×SSC/0,l% SDS при 65°С.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10003744A EP2377888A1 (en) | 2010-04-07 | 2010-04-07 | Fusion protein |
| PCT/EP2011/001711 WO2011124370A1 (en) | 2010-04-07 | 2011-04-06 | Fusion protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201201234A1 true EA201201234A1 (ru) | 2013-04-30 |
| EA023016B1 EA023016B1 (ru) | 2016-04-29 |
Family
ID=42540350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201201234A EA023016B1 (ru) | 2010-04-07 | 2011-04-06 | Составной белок |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20130130315A1 (ru) |
| EP (2) | EP2377888A1 (ru) |
| JP (1) | JP2013532954A (ru) |
| CN (1) | CN102906116B (ru) |
| AU (1) | AU2011238084B2 (ru) |
| CA (1) | CA2795142A1 (ru) |
| EA (1) | EA023016B1 (ru) |
| WO (1) | WO2011124370A1 (ru) |
| ZA (1) | ZA201207425B (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014140176A1 (en) * | 2013-03-15 | 2014-09-18 | Vaccibody As | Targeting vaccines for veterinary use |
| CN105820246A (zh) | 2015-01-07 | 2016-08-03 | 上海张江生物技术有限公司 | 一种新型重组抗TNFα嵌合单克隆抗体制备方法及用途 |
| CN113912694B (zh) * | 2019-07-24 | 2023-05-30 | 暨南大学 | 靶向cd133的结合蛋白和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD110000A1 (ru) | 1973-12-11 | 1974-12-05 | ||
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US20070071744A1 (en) * | 2002-06-07 | 2007-03-29 | Gotz Munch | Agents which bind to epitopes of glycoprotein VI |
| EP1369128A1 (en) | 2002-06-07 | 2003-12-10 | Procorde GmbH | Inhibitors of glycoprotein VI and their therapeutic use |
| US20090130021A1 (en) * | 2002-06-07 | 2009-05-21 | Gotz Munch | Methods, products and uses involving platelets and/or the vasculature |
| DE102007010306A1 (de) | 2007-02-22 | 2008-08-28 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Bispezifisches Fusionsprotein mit therapeutischem und diagnostischem Potenzial |
| WO2008119566A2 (en) * | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific bispecific binders |
| MX2010002683A (es) * | 2007-09-14 | 2010-03-26 | Amgen Inc | Poblaciones de anticuerpos homogeneos. |
| WO2009102493A2 (en) * | 2008-02-12 | 2009-08-20 | The Board Of Trustees Of The Leland Stanford Junior University | Use of egfrviii to identify and target cancer stem cells |
| DE102010013887A1 (de) * | 2010-03-30 | 2011-10-06 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Fusionsprotein und dessen Verwendungen |
-
2010
- 2010-04-07 EP EP10003744A patent/EP2377888A1/en not_active Withdrawn
-
2011
- 2011-04-06 WO PCT/EP2011/001711 patent/WO2011124370A1/en active Application Filing
- 2011-04-06 EP EP11712780A patent/EP2556092A1/en not_active Withdrawn
- 2011-04-06 EA EA201201234A patent/EA023016B1/ru not_active IP Right Cessation
- 2011-04-06 AU AU2011238084A patent/AU2011238084B2/en not_active Ceased
- 2011-04-06 CA CA2795142A patent/CA2795142A1/en not_active Abandoned
- 2011-04-06 JP JP2013503034A patent/JP2013532954A/ja active Pending
- 2011-04-06 CN CN201180022857.8A patent/CN102906116B/zh not_active Expired - Fee Related
- 2011-04-06 US US13/638,694 patent/US20130130315A1/en not_active Abandoned
-
2012
- 2012-10-03 ZA ZA2012/07425A patent/ZA201207425B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201207425B (en) | 2014-03-26 |
| AU2011238084B2 (en) | 2014-05-15 |
| CA2795142A1 (en) | 2011-10-13 |
| CN102906116A (zh) | 2013-01-30 |
| CN102906116B (zh) | 2015-06-17 |
| AU2011238084A1 (en) | 2012-11-01 |
| EP2377888A1 (en) | 2011-10-19 |
| EP2556092A1 (en) | 2013-02-13 |
| US20130130315A1 (en) | 2013-05-23 |
| EA023016B1 (ru) | 2016-04-29 |
| WO2011124370A1 (en) | 2011-10-13 |
| JP2013532954A (ja) | 2013-08-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201201126A1 (ru) | Полипептид, обладающий активностью целлобиогидролазы, и его применение | |
| EA201300060A1 (ru) | Полипептид, обладающий или содействующий активности деградации углеводного материала, и его применение | |
| WO2011112089A3 (en) | Mutated rep encoding sequences for use in aav production | |
| EA201101553A1 (ru) | Полипептид, деградирующий углеводы, и его применения | |
| EA200901430A1 (ru) | Варианты фермента аспарагиназы и их применение | |
| EA201300058A1 (ru) | Полипептид, обладающий бета-глюкозидазной активностью, и его применение | |
| NZ616761A (en) | Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same | |
| EA201001881A1 (ru) | Пролинспецифичная протеаза из penicillium chrysogenum | |
| NZ600348A (en) | Anti-c5a binding moieties with high blocking activity | |
| GB201206559D0 (en) | Polypeptide | |
| MX2012015142A (es) | Polipeptidos que tiene actividad beta-glucosidasa y usos del mismo. | |
| NZ612323A (en) | Nucleic acid molecules that confer resistance to coleopteran pests | |
| NZ596764A (en) | N-glycan core beta-galactosyltransferase and uses thereof | |
| GB201201178D0 (en) | Novel enzymes | |
| NZ609127A (en) | Novel fucosyltransferases and their applications | |
| RU2010116163A (ru) | Вакцины и компоненты вакцин для подавления микробных клеток | |
| MX2009009846A (es) | Mejora del rendimiento tolerante al frio y a la sal de plantas con el gen de factor de transcripcion snac2 del arroz. | |
| NZ602351A (en) | Axmi-115, axmi-113, axmi-005, axmi-163 and axmi-184 : vip3a insecticidal proteins from bacillus thuringiensis and methods for their use | |
| DK1824970T3 (da) | Thricoderma reesei-glycoamylase og homologer heraf | |
| WO2008101893A3 (en) | Novel sialidase | |
| ES2543203T3 (es) | Grupo de genes NRPS-PKS, su manipulación y su utilidad | |
| MX2012009847A (es) | Celulasas de familia 5 modificada y usos de las mismas. | |
| EA201300057A1 (ru) | Полипептид, обладающий углеводдеградирующей активностью, и его применения | |
| IN2012DN02373A (ru) | ||
| EP2589658A4 (en) | PARTICLE POLYPEPTIDE OF THE REIC / DKK-3 PROTEIN |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |