EA201200991A1 - METHOD FOR EXPRESS DETERMINING BLOOD ATHEROGENICITY - Google Patents

METHOD FOR EXPRESS DETERMINING BLOOD ATHEROGENICITY

Info

Publication number
EA201200991A1
EA201200991A1 EA201200991A EA201200991A EA201200991A1 EA 201200991 A1 EA201200991 A1 EA 201200991A1 EA 201200991 A EA201200991 A EA 201200991A EA 201200991 A EA201200991 A EA 201200991A EA 201200991 A1 EA201200991 A1 EA 201200991A1
Authority
EA
Eurasian Patent Office
Prior art keywords
express
mlp
determining blood
blood
atherogenicity
Prior art date
Application number
EA201200991A
Other languages
Russian (ru)
Inventor
Леонид Федорович ПАНЧЕНКО
Аслан Амирханович КУБАТИЕВ
Original Assignee
Федеральное Государственное Бюджетное Учреждение "Нии Общей Патологии И Патофизиологии" Рамн
ШОЙБОНОВ, Батожаб Батожаргалович
БАРОНЕЦ, Валерия Юрьевна
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Федеральное Государственное Бюджетное Учреждение "Нии Общей Патологии И Патофизиологии" Рамн, ШОЙБОНОВ, Батожаб Батожаргалович, БАРОНЕЦ, Валерия Юрьевна filed Critical Федеральное Государственное Бюджетное Учреждение "Нии Общей Патологии И Патофизиологии" Рамн
Publication of EA201200991A1 publication Critical patent/EA201200991A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/323—Arteriosclerosis, Stenosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Изобретение относится к клинической биохимии и может быть использовано для экспресс-определения атерогенности крови путем агрегации множественно модифицированных липопротеинов (ммЛП) крови. ммЛП агрегируют в буфере, содержащем 10% ПВП 12600 при соотношении плазма:буфер (1:8). Способ выявляет доклинические стадии атеросклероза до морфологических изменений интимо-медильного комплекса брахиоцефальных артерий. Разработанная тест-система также может быть использована для контроля эффективности терапии атеросклеротических заболеваний.The invention relates to clinical biochemistry and can be used for the rapid determination of atherogenic blood by aggregation of multiply modified lipoproteins (MLP) of blood. MLP is aggregated in a buffer containing 10% PVP 12600 with a plasma: buffer ratio (1: 8). The method reveals the preclinical stages of atherosclerosis to the morphological changes of the intima-slow complex of the brachiocephalic arteries. The developed test system can also be used to monitor the effectiveness of the treatment of atherosclerotic diseases.

EA201200991A 2010-08-24 2011-08-16 METHOD FOR EXPRESS DETERMINING BLOOD ATHEROGENICITY EA201200991A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2010135176/15A RU2437098C1 (en) 2010-08-24 2010-08-24 Method for instant determination of blood atherogenicity (versions)
PCT/RU2011/000620 WO2012026850A1 (en) 2010-08-24 2011-08-16 Method for the rapid determination of blood atherogenicity

Publications (1)

Publication Number Publication Date
EA201200991A1 true EA201200991A1 (en) 2013-02-28

Family

ID=45404444

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200991A EA201200991A1 (en) 2010-08-24 2011-08-16 METHOD FOR EXPRESS DETERMINING BLOOD ATHEROGENICITY

Country Status (3)

Country Link
EA (1) EA201200991A1 (en)
RU (1) RU2437098C1 (en)
WO (1) WO2012026850A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2501013C1 (en) * 2012-07-26 2013-12-10 Батожаб Батожаргалович Шойбонов Method for determining minimum modified lipoproteins of low density in serum or plasma of human blood
RU2497116C1 (en) * 2012-08-10 2013-10-27 Батожаб Батожаргалович Шойбонов Method to determine atherogenicity of human blood
RU2549467C1 (en) * 2013-12-19 2015-04-27 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт нормальной физиологии им. П.К. Анохина" Российской академии медицинских наук (ФГБУ "НИИНФ им. П.К. Анохина" РАМН) Method of determination of atherogenicity of immune complexes
RU2549466C1 (en) * 2013-12-19 2015-04-27 Федеральное Государственное Бюджетное Учреждение "Нии Общей Патологии И Патофизиологии" Рамн Instant method for assessing atherogenicity of immune complexes of human blood serum
RU2696569C1 (en) * 2018-11-15 2019-08-05 Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский экономический университет им. Г.В. Плеханова" Method for determining atherogenic activity of food products

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1467516A1 (en) * 1986-07-14 1989-03-23 Белорусский Научно-Исследовательский Институт Туберкулеза Method of analyzing disturbance of lipoprotein spectrum of blood plasma
RU94010187A (en) * 1994-03-22 1996-09-27 Институт хирургии Восточно-сибирского научного центра СО РАМН Method of determining aggregation capacity of atherogenic lipoproteins
US7700360B2 (en) * 2004-04-20 2010-04-20 Kimberly-Clark Worldwide, Inc. Optical method and system to determine distribution of lipid particles in a sample

Also Published As

Publication number Publication date
RU2437098C1 (en) 2011-12-20
WO2012026850A1 (en) 2012-03-01

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