EA201200241A1 - Новая кристаллическая форма органического соединения и способ её получения - Google Patents

Новая кристаллическая форма органического соединения и способ её получения

Info

Publication number
EA201200241A1
EA201200241A1 EA201200241A EA201200241A EA201200241A1 EA 201200241 A1 EA201200241 A1 EA 201200241A1 EA 201200241 A EA201200241 A EA 201200241A EA 201200241 A EA201200241 A EA 201200241A EA 201200241 A1 EA201200241 A1 EA 201200241A1
Authority
EA
Eurasian Patent Office
Prior art keywords
obtaining
organic compounds
crystal form
new crystal
norpregna
Prior art date
Application number
EA201200241A
Other languages
English (en)
Other versions
EA019114B1 (ru
Inventor
Аттила Балаж
Янош Чёргей
Адам Деметер
Чаба Санта
Original Assignee
Рихтер Гедеон Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Нирт. filed Critical Рихтер Гедеон Нирт.
Publication of EA201200241A1 publication Critical patent/EA201200241A1/ru
Publication of EA019114B1 publication Critical patent/EA019114B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к новой кристаллической форме II 17α-ацетокси-21-метокси-11β-[4-N,N-диметиламинофенил]-19-норпрегна-4,9-диен-3,20-диона (также известного как CDB-4124), способам её получения и содержащей её фармацевтической композиции. Форма II может быть получена кристаллизацией из различных сред, например из сложных эфиров C-C-спиртов и карбоновых кислот, кетонов, циклогексана, ацетонитрила, диметилформамида, диметилсульфоксида, воды и их смесей.
EA201200241A 2009-08-05 2010-08-05 НОВАЯ КРИСТАЛЛИЧЕСКАЯ ФОРМА 17α-АЦЕТОКСИ-21-МЕТОКСИ-11β-[4-N,N-ДИМЕТИЛАМИНОФЕНИЛ]-19-НОРПРЕГНА-4,9-ДИЕН-3,20-ДИОНА И СПОСОБ ЕЁ ПОЛУЧЕНИЯ EA019114B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0900487A HUP0900487A2 (hu) 2009-08-05 2009-08-05 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos polimorf módosulata és eljárás elõállítására
PCT/HU2010/000088 WO2011015892A2 (en) 2009-08-05 2010-08-05 Novel crystal form of an organic compound and process for the preparation thereof

Publications (2)

Publication Number Publication Date
EA201200241A1 true EA201200241A1 (ru) 2012-07-30
EA019114B1 EA019114B1 (ru) 2014-01-30

Family

ID=89989159

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200241A EA019114B1 (ru) 2009-08-05 2010-08-05 НОВАЯ КРИСТАЛЛИЧЕСКАЯ ФОРМА 17α-АЦЕТОКСИ-21-МЕТОКСИ-11β-[4-N,N-ДИМЕТИЛАМИНОФЕНИЛ]-19-НОРПРЕГНА-4,9-ДИЕН-3,20-ДИОНА И СПОСОБ ЕЁ ПОЛУЧЕНИЯ

Country Status (7)

Country Link
US (2) US9221870B2 (ru)
EP (1) EP2462154B1 (ru)
EA (1) EA019114B1 (ru)
ES (1) ES2546098T3 (ru)
HU (2) HUP0900487A2 (ru)
PL (1) PL2462154T3 (ru)
WO (1) WO2011015892A2 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900171A2 (hu) * 2009-03-20 2010-12-28 Richter Gedeon Nyrt 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3921059A1 (de) * 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
DE4042007A1 (de) * 1990-12-22 1992-06-25 Schering Ag 6,7-modifizierte-11(beta)-aryl-4-estrene
US6900193B1 (en) * 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
US6861415B2 (en) * 1996-05-01 2005-03-01 The United States Of America As Represented By The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
EP1242444B1 (en) 1999-12-29 2005-07-20 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Process for preparing 17alpha-acetoxy-11beta- 4-n,n-(dimethylamino)phenyl]-21-methoxy-19-norpregna-4,9-diene-3,20-dione, intermediates useful in the process, and processes for preparing such intermediates
ES2307604T3 (es) 2000-03-17 2008-12-01 The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services 19-norpregnadienodiona 17-a sustituidos, 11-b-sustituido-4-arilo y 21-sustituidos como nuevos agentes antiprogestacionales.
US8044223B2 (en) * 2003-04-04 2011-10-25 Bridge Organics Co. Crystalline 19-norsteroids
US8173626B2 (en) * 2006-03-08 2012-05-08 Danco Laboratories Llc Methods, dosing regimens and medications using anti-progestational agents for the treatment of disorders
BRPI0806572A2 (pt) * 2007-01-17 2014-05-06 Repros Therapeutics Inc Composição e método de produção de efeito antiprogestacional, de indução menstrual, de tratamento de endometriose, da dismenorreia, de tumores dependentes de hormônio endócrino, de meningiomas, de fibriomas uterinos, de inibição da proliferação endometrial uterina, de indução de trabalho de parto e de contracepção.
HU228636B1 (en) * 2007-06-27 2013-04-29 Richter Gedeon Nyrt Industrial method for the synthesis of 17-acetoxy-11betha-4[-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process
TW201002736A (en) * 2008-04-28 2010-01-16 Repros Therapeutics Inc Compositions and methods for treating progesterone-dependent conditions
TWI477276B (zh) * 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
HUP0900171A2 (hu) 2009-03-20 2010-12-28 Richter Gedeon Nyrt 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására

Also Published As

Publication number Publication date
EP2462154A2 (en) 2012-06-13
HUE025397T2 (en) 2016-02-29
US20120142655A1 (en) 2012-06-07
EP2462154B1 (en) 2015-06-24
ES2546098T3 (es) 2015-09-18
PL2462154T3 (pl) 2015-12-31
WO2011015892A3 (en) 2011-03-31
US20160220585A1 (en) 2016-08-04
EA019114B1 (ru) 2014-01-30
HUP0900487A2 (hu) 2011-03-28
HU0900487D0 (en) 2009-09-28
US9221870B2 (en) 2015-12-29
WO2011015892A2 (en) 2011-02-10

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU