EA201171232A1 - Способ переноса полипептидов в клетки - Google Patents

Способ переноса полипептидов в клетки

Info

Publication number
EA201171232A1
EA201171232A1 EA201171232A EA201171232A EA201171232A1 EA 201171232 A1 EA201171232 A1 EA 201171232A1 EA 201171232 A EA201171232 A EA 201171232A EA 201171232 A EA201171232 A EA 201171232A EA 201171232 A1 EA201171232 A1 EA 201171232A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cells
relates
polypeptide
addition
polypeptide transfer
Prior art date
Application number
EA201171232A
Other languages
English (en)
Other versions
EA020583B1 (ru
Inventor
Саша Барабас
Катрин Эдмайер
Людвиг Демль
Original Assignee
Лофиус Биосайенсез Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лофиус Биосайенсез Гмбх filed Critical Лофиус Биосайенсез Гмбх
Publication of EA201171232A1 publication Critical patent/EA201171232A1/ru
Publication of EA020583B1 publication Critical patent/EA020583B1/ru

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Заявленное изобретение относится к способу переноса полипептидов в клетки. Кроме того, заявленное изобретение относится к детекции специфических к полипептидам иммунных клеток и примированию, выращиванию и реактивации специфических к полипептиду Т-клеток. Помимо этого заявленное изобретение относится к полипептидам, получаемым при помощи способов согласно заявленному изобретению, в комбинации с мочевиной, и их применению в исследованиях, диагностике или лечении и профилактике заболеваний человека и животных.
EA201171232A 2009-04-09 2010-04-09 Способ переноса полипептидов в клетки EA020583B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09157777A EP2239569A1 (en) 2009-04-09 2009-04-09 Method for polypeptide transfer into cells
PCT/EP2010/054711 WO2010115984A1 (en) 2009-04-09 2010-04-09 Method for polypeptide transfer into cells

Publications (2)

Publication Number Publication Date
EA201171232A1 true EA201171232A1 (ru) 2012-05-30
EA020583B1 EA020583B1 (ru) 2014-12-30

Family

ID=40974538

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171232A EA020583B1 (ru) 2009-04-09 2010-04-09 Способ переноса полипептидов в клетки

Country Status (11)

Country Link
US (2) US9476878B2 (ru)
EP (2) EP2239569A1 (ru)
KR (1) KR101835647B1 (ru)
CN (1) CN102460161B (ru)
AU (1) AU2010233668B2 (ru)
BR (1) BRPI1014579A2 (ru)
CA (1) CA2758159C (ru)
EA (1) EA020583B1 (ru)
ES (1) ES2653561T3 (ru)
SG (2) SG175153A1 (ru)
WO (1) WO2010115984A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140213466A1 (en) * 2010-11-19 2014-07-31 Rutgers, The State University Of New Jersey High-throughput assessment method for contact hypersensitivity
JP2015516078A (ja) * 2012-05-03 2015-06-04 メディミューン，エルエルシー 試料成分の分析方法
CN103235135B (zh) * 2013-04-26 2015-02-04 史其新 一种用于表征外周调节性t细胞抑制活性的特征细胞群的检测方法及其应用
CN104031125B (zh) * 2014-06-27 2016-10-05 顾玉奎 自然杀伤t细胞活化剂多肽及其应用
CN104031126B (zh) * 2014-06-27 2016-10-12 顾玉奎 一种自然杀伤t细胞活化剂多肽及其应用
WO2016198470A2 (en) * 2015-06-08 2016-12-15 Lophius Biosciences Gmbh Composition for determination of cell-mediated immune responsiveness
CN106011060A (zh) * 2016-06-29 2016-10-12 北京中台恒基生物技术有限公司 一种体外激活和扩增nkt样细胞的方法
TW202334184A (zh) * 2021-11-10 2023-09-01 日商長瀨產業股份有限公司 ＳａｐＢ蛋白質之修飾體、ＳａｐＢ蛋白質及其修飾體之配製方法，以及溶解ＳａｐＢ蛋白質或其修飾體之水溶液

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1128005A (en) 1966-04-01 1968-09-25 Medimpex Gyogyszerkulkereskede Improvements in or relating to antigenic and allergenic preparations
FR2633518B1 (fr) 1988-06-30 1991-03-22 Merieux Inst Procede de stabilisation des vaccins et associations de vaccins a virus attenues conserves sous forme lyophilisee, et compositions obtenues
IT1237475B (it) 1989-10-06 1993-06-07 Allergeni modificati chimicamente e procedimento per la loro preparazione
BR9406821A (pt) * 1993-06-09 1996-03-26 Connaught Lab Peptideo sintético composiçao imunogenica kit de diagnostico útil para dectar anticorpos especificos de hiv em amostra de teste kit de diagnostico para detectar antigenos de hiv em amostra de teste codificaçao de molécula de ácido nucléico e anticorpo
EP0638593A1 (en) * 1993-08-02 1995-02-15 Shell Internationale Researchmaatschappij B.V. Catalyst compositions
US6977073B1 (en) * 1997-02-07 2005-12-20 Cem Cezayirli Method for stimulating an immune response
CA2330560A1 (en) 1998-04-28 1999-11-04 Washington University Methods for transducing fusion molecules
DE10212867B4 (de) 2002-03-22 2005-07-21 Hans Prof. Dr. Wolf Verwendung Harnstoff-adjuvierter Polypeptide zur Diagnose, Prophylaxe und Therapie
DK1961821T3 (da) * 2007-02-22 2009-10-12 Polymun Scient Immunbio Forsch Erythropoietin-fusionsprotein
EP2487206A3 (en) * 2008-06-18 2012-11-28 Lifebond Ltd Cross-linkable gelatin-based compositions

Also Published As

Publication number Publication date
SG10201401126QA (en) 2014-10-30
AU2010233668A1 (en) 2011-10-13
CA2758159C (en) 2017-03-14
SG175153A1 (en) 2011-11-28
EP2417451B1 (en) 2017-09-27
US9850464B2 (en) 2017-12-26
CN102460161A (zh) 2012-05-16
EP2417451A1 (en) 2012-02-15
US20120093872A1 (en) 2012-04-19
KR101835647B1 (ko) 2018-03-08
KR20120013373A (ko) 2012-02-14
CA2758159A1 (en) 2010-10-14
WO2010115984A1 (en) 2010-10-14
EA020583B1 (ru) 2014-12-30
BRPI1014579A2 (pt) 2016-04-26
CN102460161B (zh) 2017-08-29
AU2010233668B2 (en) 2014-07-17
US9476878B2 (en) 2016-10-25
ES2653561T3 (es) 2018-02-07
US20170058260A1 (en) 2017-03-02
EP2239569A1 (en) 2010-10-13

Similar Documents

Publication Publication Date Title
EA201171232A1 (ru) Способ переноса полипептидов в клетки
LTPA2017015I1 (lt) Apoptozę sukeliantys agentai, skirti vėžio ir imuninių ir autoimuninių ligų gydymui
EA201491700A1 (ru) Человеческие антитела к cd27, методы и применение
EA201400855A1 (ru) Моноклональные антитела человека, полученные из в-клеток человека и обладающие нейтрализующей активностью против вирусов гриппа а
MX2012001882A (es) Anticuerpos contra el virus sincitial respiratorio (rsv) humano y metodos de uso.
WO2012149299A3 (en) Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
IL241952A (en) Antibody that detects human leukemia inhibitor (lif) and use of anti-lif antibodies in the treatment of diseases associated with unwanted cell proliferation
MX2009011500A (es) Anticuerpos anti-mdl-1.
EA201591198A1 (ru) Антитела к gdf15
BR112013012555A2 (pt) peptídeos imunogênicos para o uso na prevenção e/ou no tratamento de doenças infecciosas, doenças autoimunes, respostas imunes a alofatores, doenças alérgicas, tumores, rejeição a enxertos e respostas imunes contra vetores virais usados para a terapia de genes ou na vacinação de genes
PL2870913T3 (pl) Urządzenie do pobierania, przechowywania i/albo obróbki krwi lub innych substancji pochodzenia ludzkiego lub zwierzęcego, i do stosowania preparatów krwiopochodnych lub innych preparatów biologicznych
EA201270571A1 (ru) Человеческие il-23-антигенсвязывающие белки
EA201290590A1 (ru) Модифицированные туберкулезные антигены
MY157564A (en) Combination pharmaceutical composition and methods of treating functional diseases or conditions of gastrointestinal tract
WO2012083302A3 (en) Compositions and methods for the treatment or prevention of human adenovirus-36 infection
WO2011035205A3 (en) Antibodies against candida, collections thereof and methods of use
UA112747C2 (uk) Лікарський засіб і спосіб профілактики інфікування віл, профілактики і лікування захворювань, що викликаються віл або асоційовані з віл, у тому числі сніду
EA201300132A1 (ru) Фармацевтическая композиция и методы лечения и профилактики заболеваний, вызванных вич или ассоциированных с вич
NZ610620A (en) Inhibitors of apoptosis and uses thereof
EP2528931A4 (en) CYCLOVIRUS AND USE METHOD THEREFOR
BRPI1012078A2 (pt) construto de proteína, composição imunogênica, molécula de ácido nucleico , métodos de induzir uma resposta imune a casb7439 e de tratar um animal humano ou não-humano, e, uso de uma composição imunogênica
EA201591522A1 (ru) Лечение реакции трансплантат против хозяина у подвергаемых трансплантации пациентов
WO2014100746A3 (en) Tspan 33 is a candidate for antibody targeted therapy for the treatment of b cell hodgkin lymphomas
BR112012000380A2 (pt) diagnóstico e tratamento de doenças autoimunes desmielinizante.
WO2008006187A3 (en) Protein complexes for prevention and treatment of diseases with angiogenesis disorders

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM