EA201100718A1 - Способ получения г-ксф человека - Google Patents

Способ получения г-ксф человека

Info

Publication number
EA201100718A1
EA201100718A1 EA201100718A EA201100718A EA201100718A1 EA 201100718 A1 EA201100718 A1 EA 201100718A1 EA 201100718 A EA201100718 A EA 201100718A EA 201100718 A EA201100718 A EA 201100718A EA 201100718 A1 EA201100718 A1 EA 201100718A1
Authority
EA
Eurasian Patent Office
Prior art keywords
obtaining
csf
csf human
human
salt
Prior art date
Application number
EA201100718A
Other languages
English (en)
Other versions
EA022782B1 (ru
Inventor
Санджив Кумар Мендиратта
Вибхор Сарасват
Панкадж Р. Пател
Original Assignee
Кадила Хелзкэр Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кадила Хелзкэр Лимитед filed Critical Кадила Хелзкэр Лимитед
Publication of EA201100718A1 publication Critical patent/EA201100718A1/ru
Publication of EA022782B1 publication Critical patent/EA022782B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к улучшенному способу получения Г-КСФ с высоким выходом за счет значительного увеличения стабильности плазмиды, индуцированной солями, во время фазы продуцирования.
EA201100718A 2006-03-06 2007-03-05 Способ получения г-ксф человека EA022782B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN309MU2006 2006-03-06

Publications (2)

Publication Number Publication Date
EA201100718A1 true EA201100718A1 (ru) 2012-02-28
EA022782B1 EA022782B1 (ru) 2016-03-31

Family

ID=38436804

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200870320A EA015498B1 (ru) 2006-03-06 2007-03-05 Способ получения г-ксф человека
EA201100718A EA022782B1 (ru) 2006-03-06 2007-03-05 Способ получения г-ксф человека

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200870320A EA015498B1 (ru) 2006-03-06 2007-03-05 Способ получения г-ксф человека

Country Status (18)

Country Link
US (2) US8021862B2 (ru)
EP (2) EP2182007B1 (ru)
JP (2) JP4927103B2 (ru)
KR (1) KR101176794B1 (ru)
CN (2) CN102776261B (ru)
AP (2) AP2647A (ru)
AU (1) AU2007224331B2 (ru)
BR (1) BRPI0707078A2 (ru)
CA (1) CA2642654C (ru)
DK (2) DK1994138T3 (ru)
EA (2) EA015498B1 (ru)
HK (2) HK1127617A1 (ru)
MX (1) MX2008011407A (ru)
MY (1) MY149168A (ru)
NZ (2) NZ571337A (ru)
PL (2) PL2182007T3 (ru)
WO (1) WO2007102174A2 (ru)
ZA (1) ZA200806978B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009066320A2 (en) * 2007-09-21 2009-05-28 Cadila Healthcare Limited Fusion protein systems suitable for high expression of peptides
WO2011086447A2 (en) 2010-01-12 2011-07-21 Lupin Limited Fermentation process for the preparation of recombinant heterologous proteins
CN108103243A (zh) * 2018-01-04 2018-06-01 哈尔滨瀚邦医疗科技有限公司 一种猪乙脑病毒遗传稳定性的检测方法及应用
CN114350588B (zh) * 2021-12-31 2024-03-15 山东新时代药业有限公司 一种rhG-CSF的发酵培养基及其发酵方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107846D0 (en) * 1990-04-30 1991-05-29 Ici Plc Polypeptides
KR101128055B1 (ko) * 2004-12-20 2012-03-29 카딜라 핼쓰캐어 리미티드 고 수준의 인터페론 베타를 제조하는 방법

Also Published As

Publication number Publication date
KR101176794B1 (ko) 2012-08-24
ZA200806978B (en) 2009-05-27
EP1994138A2 (en) 2008-11-26
CN102776261B (zh) 2014-09-24
MY149168A (en) 2013-07-31
AU2007224331B2 (en) 2011-05-26
EA200870320A1 (ru) 2009-02-27
US8492120B2 (en) 2013-07-23
PL2182007T3 (pl) 2014-06-30
WO2007102174A2 (en) 2007-09-13
HK1127617A1 (en) 2009-10-02
CA2642654C (en) 2014-04-22
CN101410410A (zh) 2009-04-15
JP2009528836A (ja) 2009-08-13
NZ596111A (en) 2012-12-21
EA015498B1 (ru) 2011-08-30
CN101410410B (zh) 2013-06-12
CN102776261A (zh) 2012-11-14
JP5460660B2 (ja) 2014-04-02
US20110070611A1 (en) 2011-03-24
AP2012006440A0 (en) 2012-08-31
WO2007102174A3 (en) 2008-01-03
CA2642654A1 (en) 2007-09-13
KR20080104011A (ko) 2008-11-28
DK1994138T3 (da) 2014-05-12
HK1176645A1 (en) 2013-08-02
US8021862B2 (en) 2011-09-20
EA022782B1 (ru) 2016-03-31
AU2007224331A1 (en) 2007-09-13
NZ571337A (en) 2011-12-22
PL1994138T3 (pl) 2014-08-29
EP1994138B1 (en) 2014-04-30
EP2182007A1 (en) 2010-05-05
MX2008011407A (es) 2008-09-24
AP2647A (en) 2013-04-17
AP2008004592A0 (en) 2008-08-31
AP3142A (en) 2015-02-28
BRPI0707078A2 (pt) 2011-04-19
EP2182007B1 (en) 2014-03-05
US20090305354A1 (en) 2009-12-10
DK2182007T3 (da) 2014-04-22
JP2011229541A (ja) 2011-11-17
JP4927103B2 (ja) 2012-05-09

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU