EA201070455A1 - Твердые формы (s)-2-амино-3-(4-(2-амино-6-((r)-2,2,2-трифтор-1-(3'-метоксибифенил-4-ил)этокси)пиримидин-4-ил)фенил)пропановой кислоты и способы их применения - Google Patents

Твердые формы (s)-2-амино-3-(4-(2-амино-6-((r)-2,2,2-трифтор-1-(3'-метоксибифенил-4-ил)этокси)пиримидин-4-ил)фенил)пропановой кислоты и способы их применения

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Publication number
EA201070455A1
EA201070455A1 EA201070455A EA201070455A EA201070455A1 EA 201070455 A1 EA201070455 A1 EA 201070455A1 EA 201070455 A EA201070455 A EA 201070455A EA 201070455 A EA201070455 A EA 201070455A EA 201070455 A1 EA201070455 A1 EA 201070455A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amino
phenyl
triftor
methoxibiphenyl
etoxi
Prior art date
Application number
EA201070455A
Other languages
English (en)
Inventor
Синия Иимура
Хой-Инь Ли
Цюлин Сонг
Вэньсюэ У
Мэттью Манчжу Чжао
Original Assignee
Лексикон Фармасьютикалз , Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40344344&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201070455(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Лексикон Фармасьютикалз , Инк. filed Critical Лексикон Фармасьютикалз , Инк.
Publication of EA201070455A1 publication Critical patent/EA201070455A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Раскрыты твердые формы (S)-2-амино-3-(4-(2-амино-6-((R)-2,2,2-трифтор-1-(3'-метоксибифенил-4-ил)этокси)пиримидин-4-ил)фенил)пропановой кислоты и ее солей.
EA201070455A 2007-10-08 2008-10-07 Твердые формы (s)-2-амино-3-(4-(2-амино-6-((r)-2,2,2-трифтор-1-(3'-метоксибифенил-4-ил)этокси)пиримидин-4-ил)фенил)пропановой кислоты и способы их применения EA201070455A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97830307P 2007-10-08 2007-10-08
PCT/US2008/079042 WO2009048864A1 (en) 2007-10-08 2008-10-07 Solid forms of (s)-2-amino-3-(4-(2-amino-6-((r)-2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid and methods of their use

Publications (1)

Publication Number Publication Date
EA201070455A1 true EA201070455A1 (ru) 2010-08-30

Family

ID=40344344

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070455A EA201070455A1 (ru) 2007-10-08 2008-10-07 Твердые формы (s)-2-амино-3-(4-(2-амино-6-((r)-2,2,2-трифтор-1-(3'-метоксибифенил-4-ил)этокси)пиримидин-4-ил)фенил)пропановой кислоты и способы их применения

Country Status (20)

Country Link
US (1) US20090099206A1 (ru)
EP (1) EP2231618A1 (ru)
JP (1) JP2010540665A (ru)
KR (1) KR20100066548A (ru)
CN (1) CN101932563A (ru)
AR (1) AR068837A1 (ru)
AU (1) AU2008310979A1 (ru)
BR (1) BRPI0818350A2 (ru)
CA (1) CA2701904A1 (ru)
CL (1) CL2008002980A1 (ru)
CO (1) CO6270323A2 (ru)
EA (1) EA201070455A1 (ru)
EC (1) ECSP10010162A (ru)
IL (1) IL204582A0 (ru)
MX (1) MX2010003803A (ru)
PE (1) PE20091213A1 (ru)
TW (1) TW200932729A (ru)
UY (1) UY31381A1 (ru)
WO (1) WO2009048864A1 (ru)
ZA (1) ZA201001870B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7855291B2 (en) * 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
US7897763B2 (en) 2005-12-29 2011-03-01 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
ES2684821T3 (es) 2005-12-29 2018-10-04 Lexicon Pharmaceuticals, Inc. Derivados de aminoácidos multicíclicos y métodos de su uso
AU2008268409B2 (en) * 2007-06-26 2013-12-05 Lexicon Pharmaceuticals, Inc. Compositions comprising tryptophan hydroxylase inhibitors
TWI439457B (zh) 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法
EP2282756A4 (en) 2008-03-31 2012-05-02 Univ Columbia METHOD FOR DIAGNOSIS, PREVENTION AND TREATMENT OF DISEASES OF BONE MEASURES
EP2504008A1 (en) * 2009-11-23 2012-10-03 Lexicon Pharmaceuticals, Inc. Methods and assays for the treatment of irritable bowel syndrome
US20130303763A1 (en) * 2012-03-30 2013-11-14 Michael D. Gershon Methods and compositions for the treatment of necrotizing enterocolitis
WO2020099929A1 (en) * 2018-11-14 2020-05-22 Roivant Sciences Gmbh A crystalline spirocyclic compound inhibitor of tryptophan hydroxylase 1 (tph1) for treating diseases or disorders associated with peripheral serotonin
CN115697968B (zh) * 2020-05-28 2024-03-29 杭州中美华东制药有限公司 (s)-2-氨基-3-(4-(2,3-二甲基吡啶-4-基)苯基丙酸甲酯及其盐的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7382793B1 (en) * 2002-01-17 2008-06-03 Juniper Networks, Inc. Systems and methods for determining the bandwidth used by a queue
US7855291B2 (en) * 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
US7897763B2 (en) * 2005-12-29 2011-03-01 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
ES2684821T3 (es) * 2005-12-29 2018-10-04 Lexicon Pharmaceuticals, Inc. Derivados de aminoácidos multicíclicos y métodos de su uso
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
MX2009013990A (es) * 2007-06-26 2010-03-30 Lexicon Pharmaceuticals Inc Metodos para tratar enfermedades y trastornos mediados por serotonina.
AU2008268409B2 (en) * 2007-06-26 2013-12-05 Lexicon Pharmaceuticals, Inc. Compositions comprising tryptophan hydroxylase inhibitors
BRPI0814105A2 (pt) * 2007-07-11 2015-02-03 Lexicon Pharmaceuticals Inc Métodos e composições para o tratamento de hipertensão pulmonar e doenças e distúrbios relacionados
CA2694443A1 (en) * 2007-07-26 2009-01-29 Lexicon Pharmaceuticals, Inc. Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein

Also Published As

Publication number Publication date
BRPI0818350A2 (pt) 2017-10-10
AU2008310979A1 (en) 2009-04-16
MX2010003803A (es) 2010-04-21
AR068837A1 (es) 2009-12-09
PE20091213A1 (es) 2009-08-26
CA2701904A1 (en) 2009-04-16
ECSP10010162A (es) 2010-06-29
EP2231618A1 (en) 2010-09-29
CL2008002980A1 (es) 2009-03-20
UY31381A1 (es) 2009-04-30
IL204582A0 (en) 2010-11-30
JP2010540665A (ja) 2010-12-24
ZA201001870B (en) 2011-06-29
KR20100066548A (ko) 2010-06-17
TW200932729A (en) 2009-08-01
CO6270323A2 (es) 2011-04-20
WO2009048864A1 (en) 2009-04-16
US20090099206A1 (en) 2009-04-16
CN101932563A (zh) 2010-12-29

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