EA200970812A1 - Способ лечения и предупреждения артрита - Google Patents

Способ лечения и предупреждения артрита

Info

Publication number
EA200970812A1
EA200970812A1 EA200970812A EA200970812A EA200970812A1 EA 200970812 A1 EA200970812 A1 EA 200970812A1 EA 200970812 A EA200970812 A EA 200970812A EA 200970812 A EA200970812 A EA 200970812A EA 200970812 A1 EA200970812 A1 EA 200970812A1
Authority
EA
Eurasian Patent Office
Prior art keywords
arthritis
group
prevention
treatment
acyl group
Prior art date
Application number
EA200970812A
Other languages
English (en)
Other versions
EA017183B1 (ru
Inventor
Джон А. Секрист
Вильям Р. Вауд
Жикан Ку
Ксянгмин Куи
Original Assignee
Саузерн Рисерч Инститьют
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Саузерн Рисерч Инститьют filed Critical Саузерн Рисерч Инститьют
Publication of EA200970812A1 publication Critical patent/EA200970812A1/ru
Publication of EA017183B1 publication Critical patent/EA017183B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Предложены соединения, представленные формулой 1где R независимо представляет собой Н, алифатическую ацильную группу или ароматическую ацильную группу; А выбирают из группы, включающейгде X выбирают из группы, включающей водород, галоген, алкокси, алкил, галоалкил, алкенил, галоалкенил, алкинил, амино, моноалкиламино, диалкиламино, циано и нитро, которые применяются для лечения или предупреждения артрита, в том числе ревматоидного артрита.
EA200970812A 2007-03-23 2008-03-24 Способ лечения и предупреждения артрита EA017183B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89654907P 2007-03-23 2007-03-23
PCT/US2008/058008 WO2008118852A1 (en) 2007-03-23 2008-03-24 Method for treating and preventing arthritis

Publications (2)

Publication Number Publication Date
EA200970812A1 true EA200970812A1 (ru) 2010-04-30
EA017183B1 EA017183B1 (ru) 2012-10-30

Family

ID=39775380

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970812A EA017183B1 (ru) 2007-03-23 2008-03-24 Способ лечения и предупреждения артрита

Country Status (14)

Country Link
US (4) US20080234275A1 (ru)
EP (1) EP2124553B1 (ru)
JP (1) JP5417184B2 (ru)
KR (1) KR101582570B1 (ru)
CN (1) CN101641011B (ru)
AU (1) AU2008230957B2 (ru)
BR (1) BRPI0809123A2 (ru)
CA (1) CA2679391C (ru)
EA (1) EA017183B1 (ru)
HK (1) HK1134998A1 (ru)
MX (1) MX2009010203A (ru)
NZ (1) NZ579580A (ru)
WO (1) WO2008118852A1 (ru)
ZA (1) ZA200906010B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102702291A (zh) * 2012-06-15 2012-10-03 华东理工大学 3’-硫代核苷的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2390257A1 (en) * 1998-02-25 2011-11-30 Emory University 2'-fluoronucleosides
NZ509405A (en) * 1998-07-23 2004-10-29 Southern Res Inst Preparation of 1-(4-thio-thioarabinofuranosyl) cytosine derivatives and their use as anticancer agents and DNA replication inhibitors
US6831069B2 (en) * 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
PT1411954E (pt) * 2000-10-18 2011-03-16 Pharmasset Inc Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal

Also Published As

Publication number Publication date
EA017183B1 (ru) 2012-10-30
US20130288996A1 (en) 2013-10-31
CN101641011A (zh) 2010-02-03
NZ579580A (en) 2012-03-30
EP2124553A1 (en) 2009-12-02
US20130059811A1 (en) 2013-03-07
BRPI0809123A2 (pt) 2016-07-26
HK1134998A1 (en) 2010-05-28
CA2679391C (en) 2015-02-03
EP2124553B1 (en) 2017-03-01
AU2008230957A1 (en) 2008-10-02
KR20090130002A (ko) 2009-12-17
CA2679391A1 (en) 2008-10-02
CN101641011B (zh) 2013-08-14
AU2008230957B2 (en) 2012-10-04
JP2010522215A (ja) 2010-07-01
EP2124553A4 (en) 2011-01-26
JP5417184B2 (ja) 2014-02-12
US20110301165A1 (en) 2011-12-08
US20080234275A1 (en) 2008-09-25
WO2008118852A1 (en) 2008-10-02
KR101582570B1 (ko) 2016-01-06
ZA200906010B (en) 2010-08-25
MX2009010203A (es) 2010-06-01

Similar Documents

Publication Publication Date Title
DK1297851T3 (da) Inhibering af histondeacetylasesom behandling af hjertehypertrofi
DK1480961T3 (da) Glutaminylbaserede DPIV-inhibitorer
EA200800760A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
DK1765816T3 (da) Substituerede 1-propinylpiperaziner med affinitet for MGluR5-receptoren til behandling af smertetilstande
EA201200669A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
EA200970486A1 (ru) Соединения для ингибирования митоза
ATE461923T1 (de) Substituierte 1h-benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren
EA200702469A1 (ru) Замещенные производные оксадиазола в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов
DE60233884D1 (de) 4(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidon-derivate als pde-4-hemmer zur behandlung von neurologischen syndromen
EA200701779A1 (ru) Производные (1,5-дифенил-1н-пиразол-3-ил)оксадиазола, их получение и их применение в терапии
CY1111596T1 (el) Υποκατεστημενες ακετοφαινονες χρησιμες ως αναστολεις pde4
CO5680420A2 (es) Compuestos de 6-amino-1h-indazol y 4-aminobenzenofurano como inhibidores de la fosfodiesterasa 4
MX2009008772A (es) Derivado piridil-triazolopirimidina o su sal, pesticida que lo contiene y proceso para su produccion.
EA201200868A1 (ru) Ингибиторы диацилглицеролацилтрансферазы
DE602004005881D1 (de) Substituierte pyrazinonverbindungen zur behandlung von entzündungen
EA200970497A1 (ru) Производные пиррола, их получение и их применение в терапии
EA200970812A1 (ru) Способ лечения и предупреждения артрита
EA200600601A1 (ru) Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы
EA200901599A1 (ru) Ненуклеозидные ингибиторы обратной транскриптазы
EA200970361A1 (ru) Ингибиторы киназы
EA200702350A1 (ru) Анилиды тиазолкарбоновой кислоты
ATE423772T1 (de) Morpholinderivate als inhibitoren der wiederaufnahme von norepinephrin
EA201070197A1 (ru) Производные 1-оксо-изоиндолин-4-карбоксамидов и 1-оксо-1,2,3,4-тетрагидроизохинолин-5-карбоксамидов, способ их получения и применение в терапии
TH83577A (th) อะมิโน-อิมิดาโซโลน สำหรับการยับยั้งของ b-ซีครีเตส
TH87279A (th) สารประกอบ 1,3-ไธอะซอล ชนิดใหม่ ที่เป็นตัวยับยั้ง hYAK3 โปรตีน

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU