EA200970692A1 - METHODS OF IMPROVING THE STABILITY OF STEROID DERIVATIVES - Google Patents
METHODS OF IMPROVING THE STABILITY OF STEROID DERIVATIVESInfo
- Publication number
- EA200970692A1 EA200970692A1 EA200970692A EA200970692A EA200970692A1 EA 200970692 A1 EA200970692 A1 EA 200970692A1 EA 200970692 A EA200970692 A EA 200970692A EA 200970692 A EA200970692 A EA 200970692A EA 200970692 A1 EA200970692 A1 EA 200970692A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- stability
- improving
- methods
- steroid derivatives
- steroid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Предлагаются композиции с улучшенной стабильностью, содержащие фармацевтически приемлемую соль соединения, относящегося к стероидам.Compositions with improved stability are provided comprising a pharmaceutically acceptable salt of a steroid compound.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88536307P | 2007-01-17 | 2007-01-17 | |
PCT/US2008/050128 WO2008088935A2 (en) | 2007-01-17 | 2008-01-03 | Pharmaceutically acceptable salts of 11- (4-aminophenyl) -19-n0rpregna-4,9 (10) -diene-3, 20-dione derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200970692A1 true EA200970692A1 (en) | 2010-02-26 |
Family
ID=39387140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970692A EA200970692A1 (en) | 2007-01-17 | 2008-01-03 | METHODS OF IMPROVING THE STABILITY OF STEROID DERIVATIVES |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP2125858A2 (en) |
JP (1) | JP2010516686A (en) |
KR (1) | KR20090105944A (en) |
CN (1) | CN101616926A (en) |
AR (1) | AR064947A1 (en) |
AU (1) | AU2008206599A1 (en) |
BR (1) | BRPI0806572A2 (en) |
CA (1) | CA2674440A1 (en) |
CL (1) | CL2008000138A1 (en) |
CR (1) | CR10924A (en) |
EA (1) | EA200970692A1 (en) |
EC (1) | ECSP099537A (en) |
IL (1) | IL199684A0 (en) |
MX (1) | MX2009007313A (en) |
TW (1) | TW200835503A (en) |
WO (1) | WO2008088935A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI477276B (en) * | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | Antiprogestin dosing regimens |
US8512745B2 (en) | 2008-12-08 | 2013-08-20 | Laboratoire Hra Pharma | Ulipristal acetate tablets |
HUP0900171A2 (en) | 2009-03-20 | 2010-12-28 | Richter Gedeon Nyrt | Novel crystal form of 17-acetoxy-11-[4-(dimethyl-amino)-phenyl]-21-metoxy-19-norpregna-4,9-dien-3,20-dione and process for it's preparation |
HUP0900487A2 (en) * | 2009-08-05 | 2011-03-28 | Richter Gedeon Nyrt | Novel crystal polymorphic form of 17-acetoxy-11 -[4-(dimethylamino)phenyl]-21-methoxy-4,9-diene-3,20-dione and process for it's preparation |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
US6020328A (en) * | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US8044223B2 (en) * | 2003-04-04 | 2011-10-25 | Bridge Organics Co. | Crystalline 19-norsteroids |
-
2008
- 2008-01-03 AU AU2008206599A patent/AU2008206599A1/en not_active Abandoned
- 2008-01-03 EA EA200970692A patent/EA200970692A1/en unknown
- 2008-01-03 MX MX2009007313A patent/MX2009007313A/en not_active Application Discontinuation
- 2008-01-03 KR KR1020097015532A patent/KR20090105944A/en not_active Application Discontinuation
- 2008-01-03 EP EP08713475A patent/EP2125858A2/en not_active Withdrawn
- 2008-01-03 CA CA002674440A patent/CA2674440A1/en not_active Abandoned
- 2008-01-03 CN CN200880002367A patent/CN101616926A/en active Pending
- 2008-01-03 JP JP2009546454A patent/JP2010516686A/en not_active Withdrawn
- 2008-01-03 WO PCT/US2008/050128 patent/WO2008088935A2/en active Application Filing
- 2008-01-03 BR BRPI0806572-1A patent/BRPI0806572A2/en not_active IP Right Cessation
- 2008-01-15 TW TW097101566A patent/TW200835503A/en unknown
- 2008-01-17 CL CL200800138A patent/CL2008000138A1/en unknown
- 2008-01-17 AR ARP080100217A patent/AR064947A1/en unknown
-
2009
- 2009-07-02 IL IL199684A patent/IL199684A0/en unknown
- 2009-07-14 CR CR10924A patent/CR10924A/en not_active Application Discontinuation
- 2009-07-23 EC EC2009009537A patent/ECSP099537A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CL2008000138A1 (en) | 2008-05-16 |
BRPI0806572A2 (en) | 2014-05-06 |
ECSP099537A (en) | 2009-08-28 |
TW200835503A (en) | 2008-09-01 |
IL199684A0 (en) | 2010-04-15 |
MX2009007313A (en) | 2009-07-15 |
CA2674440A1 (en) | 2008-07-24 |
CR10924A (en) | 2009-10-30 |
EP2125858A2 (en) | 2009-12-02 |
WO2008088935A3 (en) | 2009-03-05 |
AU2008206599A1 (en) | 2008-07-24 |
KR20090105944A (en) | 2009-10-07 |
WO2008088935A2 (en) | 2008-07-24 |
JP2010516686A (en) | 2010-05-20 |
AR064947A1 (en) | 2009-05-06 |
CN101616926A (en) | 2009-12-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO2018016I2 (en) | Niraparib or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof | |
ATE519764T1 (en) | SPIROINDOLINONE DERIVATIVES | |
ATE495176T1 (en) | SPIROINDOLINONE DERIVATIVES | |
UA107791C2 (en) | Pesticidal compositions | |
EA201070786A1 (en) | BENZOFUROPYRIMIDINONES | |
TN2010000101A1 (en) | Fungicidal 2-alkylthio-2-quinolinyloxy -acetamide derivatives | |
DK2235017T3 (en) | Spiroindolinone derivatives as anticancer agents | |
EA201000544A1 (en) | Derivatives of spiroheterocyclic pyrrolidindione, used as pesticides | |
MX2010005889A (en) | Novel thiophene derivatives. | |
PH12015501993A1 (en) | Pyrazole-amide compound and medicinal uses therefor | |
NO20091395L (en) | New thiophene derivatives | |
UA111640C2 (en) | DERIVATIVES [1,2,3] TRIAZOLO [4,5-d] PYRIMIDINE AS A cannabinoid receptor agonist 2 | |
ATE555107T1 (en) | 2-AZA-BICYCLO-Ä2,2,1-ÜHEPTAN DERIVATIVES | |
EA201170703A1 (en) | Derivatives of Adamantylbenzamide | |
RS52255B (en) | Nalmefene hydrochloride dihydrate | |
DE602008005634D1 (en) | 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives | |
TW200942524A (en) | Novel aminomethyl benzene derivatives | |
RS53586B1 (en) | Deoxyactagardine derivatives | |
EA201100612A1 (en) | NEW DERIVATIVES 2-AMIDOTHIADIAZOLE | |
EA201490761A1 (en) | R (+) - N-Formylpropylglycinone | |
CA2904820C (en) | Pyridinylpyrazoloquinoline compound | |
EA201370149A1 (en) | ANTAGONISTS RECEPTOR | |
MA32834B1 (en) | Aminocyclopentaneicarboxamide 3 acts as a shimokin receptor modulator | |
EA201001882A1 (en) | HYDROXYLICATED THYENOPYRIMIDINONES AS ANTAGONISTS OF RECEPTOR-I MELANINC-CENTERING HORMONE | |
CO6341557A2 (en) | NITROGEN DERIVATIVES OF PANCRATISTATINE |