EA200970256A1 - Биомаркеры для определения функции печени - Google Patents
Биомаркеры для определения функции печениInfo
- Publication number
- EA200970256A1 EA200970256A1 EA200970256A EA200970256A EA200970256A1 EA 200970256 A1 EA200970256 A1 EA 200970256A1 EA 200970256 A EA200970256 A EA 200970256A EA 200970256 A EA200970256 A EA 200970256A EA 200970256 A1 EA200970256 A1 EA 200970256A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- liver function
- biomarkers
- individual
- ratio
- albumin
- Prior art date
Links
- 230000003908 liver function Effects 0.000 title abstract 3
- 239000000090 biomarker Substances 0.000 title 1
- 108010023015 ischemia-modified albumin Proteins 0.000 abstract 2
- NTNWOCRCBQPEKQ-UHFFFAOYSA-N 2-azaniumyl-5-[(n'-methylcarbamimidoyl)amino]pentanoate Chemical compound CN=C(N)NCCCC(N)C(O)=O NTNWOCRCBQPEKQ-UHFFFAOYSA-N 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 102000009027 Albumins Human genes 0.000 abstract 1
- YDGMGEXADBMOMJ-LURJTMIESA-N N(g)-dimethylarginine Chemical compound CN(C)C(\N)=N\CCC[C@H](N)C(O)=O YDGMGEXADBMOMJ-LURJTMIESA-N 0.000 abstract 1
- YDGMGEXADBMOMJ-UHFFFAOYSA-N asymmetrical dimethylarginine Natural products CN(C)C(N)=NCCCC(N)C(O)=O YDGMGEXADBMOMJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/76—Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
- G01N2333/765—Serum albumin, e.g. HSA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
- G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0617581.4A GB0617581D0 (en) | 2006-09-07 | 2006-09-07 | Biomarkers for assessing liver function |
| PCT/GB2007/003362 WO2008029145A1 (en) | 2006-09-07 | 2007-09-07 | Biqmarkers for assessing liver function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200970256A1 true EA200970256A1 (ru) | 2009-08-28 |
Family
ID=37232490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200970256A EA200970256A1 (ru) | 2006-09-07 | 2007-09-07 | Биомаркеры для определения функции печени |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8455220B2 (https=) |
| EP (1) | EP2059817B1 (https=) |
| JP (1) | JP4949473B2 (https=) |
| KR (1) | KR20090083335A (https=) |
| AT (1) | ATE488772T1 (https=) |
| AU (1) | AU2007293302A1 (https=) |
| CA (1) | CA2662597A1 (https=) |
| DE (1) | DE602007010644D1 (https=) |
| EA (1) | EA200970256A1 (https=) |
| ES (1) | ES2353835T3 (https=) |
| GB (1) | GB0617581D0 (https=) |
| IL (1) | IL197271A0 (https=) |
| MX (1) | MX2009002378A (https=) |
| NO (1) | NO20090993L (https=) |
| WO (1) | WO2008029145A1 (https=) |
| ZA (1) | ZA200901432B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2823349T3 (es) | 2011-05-31 | 2021-05-06 | Univ Colorado Regents | Procedimiento para evaluación de la función hepática y el flujo sanguíneo portal |
| CA2891281C (en) | 2012-11-12 | 2023-11-28 | The Regents Of The University Of Colorado, A Body Corporate | Disease severity index for assessment of chronic liver disease and method for diagnosis of three distinct subtypes of primary sclerosing cholangitis |
| WO2014190170A1 (en) * | 2013-05-22 | 2014-11-27 | The Regents Of The University Of California | Biomarker composite test for hepatic vein pressure gradient and cirrhosis treatment |
| US10335452B2 (en) * | 2014-10-24 | 2019-07-02 | Mallinckrodt Hospital Products IP Limited | Method of treating patients with hepatorenal syndrome type 1 |
| CN105181692A (zh) * | 2015-09-30 | 2015-12-23 | 山东博科生物产业有限公司 | 一种缺血修饰白蛋白比色法检测试剂盒 |
| ES2761266T3 (es) * | 2015-11-10 | 2020-05-19 | Inst Nat Sante Rech Med | Métodos para predicción del tiempo de supervivencia de los pacientes con cirrosis alcohólica descompensada |
| US20220018852A1 (en) * | 2018-11-20 | 2022-01-20 | Inserm (Institute National De Ka Santé Et De La Recherche Médicale) | Methods and kits for detecting liver dysfunction in a subject |
| CN121331222B (zh) * | 2025-12-15 | 2026-03-10 | 北京大学 | 基于蛋白质组的慢性肝脏疾病发病预测的蛋白组合、预测模型及应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997034605A1 (en) * | 1996-03-21 | 1997-09-25 | Mayo Foundation For Medical Education And Research | Use of nicotine to treat liver disease |
| CA2415174A1 (en) * | 2000-07-06 | 2002-01-17 | Thomas W. Bell | Methods and kits for the detection of arginine compounds |
| WO2003046538A1 (en) * | 2001-11-26 | 2003-06-05 | Ischemia Technologies, Inc. | Electrochemical detection of ischemia |
| AU2003261424A1 (en) * | 2002-08-06 | 2004-02-23 | Nitromed, Inc. | Nitrosated and/or nitrosylated ursodeoxycholic acid compounds, compositions and methods of use |
| AU2003290784A1 (en) | 2002-11-15 | 2004-06-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for detecting asymmetric dimethylarginine in a biological sample |
| WO2005039598A1 (en) | 2003-10-24 | 2005-05-06 | Intermune, Inc. | Method of treating alcoholic liver disease |
| DE10351238A1 (de) * | 2003-11-03 | 2005-06-02 | Roche Diagnostics Gmbh | Diagnosestellung von akuten myokardialen, ischämischen Erkrankungen durch Kombination von Markern |
-
2006
- 2006-09-07 GB GBGB0617581.4A patent/GB0617581D0/en not_active Ceased
-
2007
- 2007-09-07 US US12/440,170 patent/US8455220B2/en active Active
- 2007-09-07 AT AT07804163T patent/ATE488772T1/de not_active IP Right Cessation
- 2007-09-07 WO PCT/GB2007/003362 patent/WO2008029145A1/en not_active Ceased
- 2007-09-07 CA CA002662597A patent/CA2662597A1/en not_active Abandoned
- 2007-09-07 ZA ZA200901432A patent/ZA200901432B/xx unknown
- 2007-09-07 JP JP2009527200A patent/JP4949473B2/ja active Active
- 2007-09-07 MX MX2009002378A patent/MX2009002378A/es not_active Application Discontinuation
- 2007-09-07 EP EP07804163A patent/EP2059817B1/en active Active
- 2007-09-07 EA EA200970256A patent/EA200970256A1/ru unknown
- 2007-09-07 KR KR1020097007160A patent/KR20090083335A/ko not_active Ceased
- 2007-09-07 DE DE602007010644T patent/DE602007010644D1/de active Active
- 2007-09-07 ES ES07804163T patent/ES2353835T3/es active Active
- 2007-09-07 AU AU2007293302A patent/AU2007293302A1/en not_active Abandoned
-
2009
- 2009-02-26 IL IL197271A patent/IL197271A0/en unknown
- 2009-03-05 NO NO20090993A patent/NO20090993L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008029145A1 (en) | 2008-03-13 |
| EP2059817B1 (en) | 2010-11-17 |
| JP2010502979A (ja) | 2010-01-28 |
| GB0617581D0 (en) | 2006-10-18 |
| ZA200901432B (en) | 2010-06-30 |
| JP4949473B2 (ja) | 2012-06-06 |
| US8455220B2 (en) | 2013-06-04 |
| AU2007293302A1 (en) | 2008-03-13 |
| DE602007010644D1 (de) | 2010-12-30 |
| EP2059817A1 (en) | 2009-05-20 |
| US20090280519A1 (en) | 2009-11-12 |
| CA2662597A1 (en) | 2008-03-13 |
| KR20090083335A (ko) | 2009-08-03 |
| NO20090993L (no) | 2009-04-03 |
| ES2353835T3 (es) | 2011-03-07 |
| IL197271A0 (en) | 2009-12-24 |
| MX2009002378A (es) | 2009-03-20 |
| ATE488772T1 (de) | 2010-12-15 |
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