EA200901229A1 - Новый способ получения левоцетиризина и его промежуточных соединений - Google Patents

Новый способ получения левоцетиризина и его промежуточных соединений

Info

Publication number
EA200901229A1
EA200901229A1 EA200901229A EA200901229A EA200901229A1 EA 200901229 A1 EA200901229 A1 EA 200901229A1 EA 200901229 A EA200901229 A EA 200901229A EA 200901229 A EA200901229 A EA 200901229A EA 200901229 A1 EA200901229 A1 EA 200901229A1
Authority
EA
Eurasian Patent Office
Prior art keywords
leobocethrizin
obtaining
new method
intermediate compounds
new
Prior art date
Application number
EA200901229A
Other languages
English (en)
Other versions
EA016523B1 (ru
Inventor
Ярослав Тихи
Рок Зупет
Аница Пецавар
Иванка Коленц
Дарья Павлин
Original Assignee
Крка, Товарна Здравил, Д. Д., Ново Место
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SI200700055A external-priority patent/SI22489A/sl
Priority claimed from SI200700191A external-priority patent/SI22586A/sl
Application filed by Крка, Товарна Здравил, Д. Д., Ново Место filed Critical Крка, Товарна Здравил, Д. Д., Ново Место
Publication of EA200901229A1 publication Critical patent/EA200901229A1/ru
Publication of EA016523B1 publication Critical patent/EA016523B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В настоящем изобретении описан новый способ получения левоцетиризина и его фармацевтически приемлемых солей присоединения кислоты с использованием дигликолевой кислоты или ее производных и новые промежуточные соединения, используемые при данном способе.
EA200901229A 2007-03-12 2008-03-12 Способ получения левоцетиризина и его промежуточных соединений EA016523B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200700055A SI22489A (sl) 2007-03-12 2007-03-12 Nov postopek za pripravo levocetirizina in njegovih intermediatov
SI200700191A SI22586A (sl) 2007-07-30 2007-07-30 Nov postopek za pripravo levocetirizina in njegovih intermediatov
PCT/EP2008/052970 WO2008110586A2 (en) 2007-03-12 2008-03-12 New process for the preparation of levocetirizine and intermediates thereof

Publications (2)

Publication Number Publication Date
EA200901229A1 true EA200901229A1 (ru) 2010-02-26
EA016523B1 EA016523B1 (ru) 2012-05-30

Family

ID=39493999

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901229A EA016523B1 (ru) 2007-03-12 2008-03-12 Способ получения левоцетиризина и его промежуточных соединений

Country Status (4)

Country Link
US (1) US8049011B2 (ru)
EP (1) EP2121643B1 (ru)
EA (1) EA016523B1 (ru)
WO (1) WO2008110586A2 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009150147A1 (en) * 2008-06-11 2009-12-17 Krka, Tovarna Zdravil, D.D., Novo Mesto New process for the preparation of levocetirizine and intermediates thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827391D0 (en) 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB9305282D0 (en) 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
CA2180993A1 (en) * 1996-07-11 1998-01-12 Yong Tao Methods for the manufacture of cetirizine
GR990100135A (el) * 1999-04-22 2000-12-29 Genepharm �.�. Μεθοδος παρασκευης του 2-(2-[4-[4-χλωροφαινυλο)(φαινυλο)μεθυλο]πιπεραζινο]αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατος αυτου
US6239277B1 (en) * 1999-10-20 2001-05-29 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
CA2488114A1 (en) 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Polymorphic forms of dihydrochloride salts of cetirizine and processes for preparation thereof
US7381821B2 (en) 2003-01-23 2008-06-03 Ucb, S.A. Piperazine derivatives and their use as synthesis intermediates

Also Published As

Publication number Publication date
EA016523B1 (ru) 2012-05-30
WO2008110586A3 (en) 2009-01-08
EP2121643B1 (en) 2013-10-23
EP2121643A2 (en) 2009-11-25
WO2008110586A2 (en) 2008-09-18
US20100105908A1 (en) 2010-04-29
US8049011B2 (en) 2011-11-01

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU