EA200870426A1 - Производные тиазолидиндиона в качестве ингибиторов pi3 киназы - Google Patents

Производные тиазолидиндиона в качестве ингибиторов pi3 киназы

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Publication number
EA200870426A1
EA200870426A1 EA200870426A EA200870426A EA200870426A1 EA 200870426 A1 EA200870426 A1 EA 200870426A1 EA 200870426 A EA200870426 A EA 200870426A EA 200870426 A EA200870426 A EA 200870426A EA 200870426 A1 EA200870426 A1 EA 200870426A1
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EA
Eurasian Patent Office
Prior art keywords
derivatives
diseases
tiazolidindion
thiazolidinedione
relates
Prior art date
Application number
EA200870426A
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English (en)
Inventor
Майкл Джерард Дарси
Стивен Дэвид Найт
Николас Д. Адамс
Стэнли Дж. Шмидт
Original Assignee
Смитклайн Бичам Корпорейшн
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Application filed by Смитклайн Бичам Корпорейшн filed Critical Смитклайн Бичам Корпорейшн
Publication of EA200870426A1 publication Critical patent/EA200870426A1/ru

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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Abstract

Настоящее изобретение относится к способу ингибирования действия/функции киназ PI3 с использованием производных тиазолидиндиона. Также настоящее изобретение относится к способу лечения одного или более патологических состояний, выбираемых из аутоиммунных нарушений, воспалительных заболеваний, сердечно-сосудистых заболеваний, нейродегенеративных заболеваний, аллергии, астмы, панкреатита, полиорганной недостаточности, болезней почек, агрегации тромбоцитов, рака, подвижности сперматозоидов, отторжения трансплантата, отторжения ткани и поражения легких, путем введения производных тиазолидиндиона.
EA200870426A 2006-04-11 2007-04-11 Производные тиазолидиндиона в качестве ингибиторов pi3 киназы EA200870426A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79113406P 2006-04-11 2006-04-11
PCT/US2007/066359 WO2007136940A2 (en) 2006-04-11 2007-04-11 Thiazolidinedione derivatives as pi3 kinase inhibitors

Publications (1)

Publication Number Publication Date
EA200870426A1 true EA200870426A1 (ru) 2009-04-28

Family

ID=38723938

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870426A EA200870426A1 (ru) 2006-04-11 2007-04-11 Производные тиазолидиндиона в качестве ингибиторов pi3 киназы

Country Status (19)

Country Link
US (1) US20090306074A1 (ru)
EP (1) EP2004189A2 (ru)
JP (1) JP2009533467A (ru)
KR (1) KR20080108611A (ru)
CN (1) CN101466377A (ru)
AR (1) AR060391A1 (ru)
AU (1) AU2007253956A1 (ru)
BR (1) BRPI0710004A2 (ru)
CA (1) CA2649224A1 (ru)
CL (1) CL2007000995A1 (ru)
CR (1) CR10354A (ru)
EA (1) EA200870426A1 (ru)
IL (1) IL194575A0 (ru)
MA (1) MA30395B1 (ru)
MX (1) MX2008013174A (ru)
NO (1) NO20084457L (ru)
PE (1) PE20080038A1 (ru)
TW (1) TW200815429A (ru)
WO (1) WO2007136940A2 (ru)

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US20080255115A1 (en) * 2007-04-11 2008-10-16 Michael Gerard Darcy Thiazolidinedione derivatives as pi3 kinase inhibitors
PE20090717A1 (es) * 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
GB0801416D0 (en) * 2008-01-25 2008-03-05 Piramed Ltd Pharmaceutical compounds
US20120245180A1 (en) 2009-09-28 2012-09-27 Glaxosmithkline Llc Combination
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AU2013238126C1 (en) 2012-03-26 2018-06-14 Nippon Chemiphar Co., Ltd. Prophylactic or therapeutic agent for giant cell tumors occurring in bone and soft tissue or for chondrosarcoma
JP6023630B2 (ja) * 2013-04-03 2016-11-09 株式会社ヤクルト本社 チアゾロン誘導体
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KR20160055932A (ko) 2013-09-25 2016-05-18 닛뽕 케미파 가부시키가이샤 골·연부에 발생하는 거세포성 종양, 연골육종 또는 골육종의 예방, 치료 또는 전이 예방을 위한 약제, 동맥색전술용 국소 주입제 및 인공골
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
US10980784B2 (en) 2018-06-15 2021-04-20 Navitor Pharmaceuticals, Inc. Rapamycin analogs and uses thereof
EP4069223A4 (en) 2019-12-05 2023-12-20 Janssen Pharmaceutica NV RAPAMYCIN ANALOGS AND THEIR USES

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MA30395B1 (fr) 2009-05-04
WO2007136940A2 (en) 2007-11-29
AR060391A1 (es) 2008-06-11
CN101466377A (zh) 2009-06-24
IL194575A0 (en) 2009-08-03
BRPI0710004A2 (pt) 2011-08-02
MX2008013174A (es) 2008-10-21
JP2009533467A (ja) 2009-09-17
AU2007253956A1 (en) 2007-11-29
TW200815429A (en) 2008-04-01
CR10354A (es) 2008-10-29
WO2007136940A3 (en) 2008-12-04
KR20080108611A (ko) 2008-12-15
PE20080038A1 (es) 2008-02-22
US20090306074A1 (en) 2009-12-10
CA2649224A1 (en) 2007-11-29
NO20084457L (no) 2009-01-07
CL2007000995A1 (es) 2008-06-27
EP2004189A2 (en) 2008-12-24

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