EA200700244A1 - СПОСОБ ПОЛУЧЕНИЯ 4-АМИНО-1-ИЗОБУТИЛ-1H-ИМИДАЗО-[4,5-c]ХИНОЛИНА (ИМИХИМОД) - Google Patents

СПОСОБ ПОЛУЧЕНИЯ 4-АМИНО-1-ИЗОБУТИЛ-1H-ИМИДАЗО-[4,5-c]ХИНОЛИНА (ИМИХИМОД)

Info

Publication number
EA200700244A1
EA200700244A1 EA200700244A EA200700244A EA200700244A1 EA 200700244 A1 EA200700244 A1 EA 200700244A1 EA 200700244 A EA200700244 A EA 200700244A EA 200700244 A EA200700244 A EA 200700244A EA 200700244 A1 EA200700244 A1 EA 200700244A1
Authority
EA
Eurasian Patent Office
Prior art keywords
imidazo
quinoline
isobutyl
imiimide
amino
Prior art date
Application number
EA200700244A
Other languages
English (en)
Inventor
Венкатасубраманиан Радхакришнан Тарур
Суреш Махадев Кадам
Анил Пурушоттам Джоши
Сачин Бабан Гавхане
Original Assignee
Ю Эс Ви ЛИМИТЕД
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ю Эс Ви ЛИМИТЕД filed Critical Ю Эс Ви ЛИМИТЕД
Publication of EA200700244A1 publication Critical patent/EA200700244A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Способ получения имихимода, включающий в себя окисление 1-изобутил-1Н-имидазо-[4,5-с]хинолина (II), предоставляющее 1-изобутил-1Н-имидазо-[4,5-с]-хинолин-5-N-оксид (III), который выделяют в чистом виде посредством получения его солянокислой соли (IV), с последующим превращением в 4-хлорпроизводное (V) и с превращением в соответствующее 4-йодпроизводное (VI), которое является новым промежуточным соединением. Это новое промежуточное соединение превращают в имихимод (VIII) и очищают посредством получения и выделения его новой соли малеиновой кислоты.
EA200700244A 2004-12-27 2004-12-27 СПОСОБ ПОЛУЧЕНИЯ 4-АМИНО-1-ИЗОБУТИЛ-1H-ИМИДАЗО-[4,5-c]ХИНОЛИНА (ИМИХИМОД) EA200700244A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2004/000411 WO2006070379A1 (en) 2004-12-27 2004-12-27 A process for preparation of 4-amino-1-isobutyl-1h-imidazo[4,5-c]-quinoline (imiquimod)

Publications (1)

Publication Number Publication Date
EA200700244A1 true EA200700244A1 (ru) 2007-06-29

Family

ID=34978938

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700244A EA200700244A1 (ru) 2004-12-27 2004-12-27 СПОСОБ ПОЛУЧЕНИЯ 4-АМИНО-1-ИЗОБУТИЛ-1H-ИМИДАЗО-[4,5-c]ХИНОЛИНА (ИМИХИМОД)

Country Status (9)

Country Link
US (2) US7678912B2 (ru)
EP (2) EP1831214A1 (ru)
JP (1) JP2008525521A (ru)
CN (1) CN101048404A (ru)
AU (2) AU2004326103A1 (ru)
CA (1) CA2582162A1 (ru)
EA (1) EA200700244A1 (ru)
WO (2) WO2006070379A1 (ru)
ZA (1) ZA200704709B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943771B2 (en) 2007-01-24 2011-05-17 Chemagis Ltd. Imiquimod production process
US7659398B2 (en) 2007-02-14 2010-02-09 Chemagis Ltd. Imiquimod production process
FR3031105B1 (fr) 2014-12-31 2018-04-06 Universite De Montpellier Nouveaux imidazo[1,2-a]quinoxalines et derives pour le traitement des cancers
FR3113287B1 (fr) 2020-08-07 2023-06-23 Phv Pharma Procédé industriel de synthèse de l’imiquimod à partir de la quinolèine-2,4-diol applicable à son utilisation pharmaceutique
CN112321512A (zh) * 2020-11-25 2021-02-05 上海吉奉生物科技有限公司 一种4,5-二碘-1h-咪唑的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73534A (en) * 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
JP2000119271A (ja) * 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd １ｈ―イミダゾピリジン誘導体
GB0211649D0 (en) * 2002-05-21 2002-07-03 Novartis Ag Organic compounds
WO2004009593A1 (en) * 2002-07-23 2004-01-29 Biogal Gyogyszergyar Rt. Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via1h-imidazo [4,5-c]quinolin-4-phthalimide intermediates
CA2536530A1 (en) * 2003-10-01 2005-04-14 Taro Pharmaceuticals U.S.A., Inc. Method of preparing 4-amino-1h-imidazo(4,5-c)quinolines and acid addition salts thereof

Also Published As

Publication number Publication date
WO2006070408B1 (en) 2007-02-22
WO2006070408A3 (en) 2006-12-21
EP1831214A1 (en) 2007-09-12
CA2582162A1 (en) 2006-07-06
EP1831219A2 (en) 2007-09-12
ZA200704709B (en) 2008-08-27
US20090209764A1 (en) 2009-08-20
JP2008525521A (ja) 2008-07-17
WO2006070379A1 (en) 2006-07-06
US7678912B2 (en) 2010-03-16
AU2005320890A1 (en) 2006-07-06
WO2006070408A2 (en) 2006-07-06
AU2004326103A1 (en) 2006-07-06
CN101048404A (zh) 2007-10-03
US20080058527A1 (en) 2008-03-06

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