EA200602138A1 - 1-ГЕТЕРОЦИКЛИЛ-1,5-ДИГИДРОПИРИДО[3,2-b]ИНДОЛ-2-ОНЫ - Google Patents
1-ГЕТЕРОЦИКЛИЛ-1,5-ДИГИДРОПИРИДО[3,2-b]ИНДОЛ-2-ОНЫInfo
- Publication number
- EA200602138A1 EA200602138A1 EA200602138A EA200602138A EA200602138A1 EA 200602138 A1 EA200602138 A1 EA 200602138A1 EA 200602138 A EA200602138 A EA 200602138A EA 200602138 A EA200602138 A EA 200602138A EA 200602138 A1 EA200602138 A1 EA 200602138A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- substituted
- indol
- hydrogen
- methanimidamidyl
- het
- Prior art date
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 methanimidamidyl Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000005625 indol-2-ones Chemical class 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Изобретение описывает 1-гетероциклил-1,5-дигидро-пиридо[3,2-b]индол-2-оны формулы (I): N-оксиды, соли, стереоизомерные формы, рацемические смеси, пролекарства, сложные эфиры и их метаболиты, в которой n представляет 1, 2 или 3; Rпредставляет водород, циано, галоид, замещенный карбонил, метанимидамидил, N-гидроксиметанимидамидил, моно- или ди(Cалкил)метанимидамидил, Hetили Het; X представляет NR, О, S, SO, SO; Rпредставляет водород, Cалкил, Салкенил, Сциклоалкил, которые являются необязательно замещенными; Rпредставляет арил, замещенный группой -COOR; или Rпредставляет: (b-1); (b-2); -CH-CH(OR)-CH-R(b-3); -СН-СН-(O-СН-СН)-OR(b-4 ); -CH-CH-(O-CH-CH)-NRR(b-5); -a=a-a=a- представляет -CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-N=CH-; -CH=CH-CH=N-; где атомы водорода в (с-1)-(с-5) могут быть заменены определенными радикалами; Rпредставляет моноциклическую или бициклическую ароматическую гетероциклическую кольцевую систему, которая может быть замещенной.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04102171 | 2004-05-17 | ||
PCT/EP2005/052264 WO2005111047A1 (en) | 2004-05-17 | 2005-05-17 | 1-heterocyclyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200602138A1 true EA200602138A1 (ru) | 2007-04-27 |
EA012330B1 EA012330B1 (ru) | 2009-08-28 |
Family
ID=34929106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200602138A EA012330B1 (ru) | 2004-05-17 | 2005-05-17 | 1-ГЕТЕРОЦИКЛИЛ-1,5-ДИГИДРОПИРИДО[3,2-b]ИНДОЛ-2-ОНЫ |
Country Status (17)
Country | Link |
---|---|
US (1) | US7615639B2 (ru) |
EP (1) | EP1758911A1 (ru) |
JP (1) | JP4898668B2 (ru) |
KR (1) | KR20070015608A (ru) |
CN (1) | CN1953983B (ru) |
AP (1) | AP2006003791A0 (ru) |
AR (1) | AR049340A1 (ru) |
AU (1) | AU2005243439B2 (ru) |
BR (1) | BRPI0511175A (ru) |
CA (1) | CA2564027A1 (ru) |
EA (1) | EA012330B1 (ru) |
IL (1) | IL178555A0 (ru) |
MX (1) | MXPA06013314A (ru) |
NO (1) | NO20065898L (ru) |
TW (1) | TW200607503A (ru) |
WO (1) | WO2005111047A1 (ru) |
ZA (1) | ZA200610587B (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1953978B (zh) * | 2004-05-17 | 2010-09-29 | 泰博特克药品有限公司 | 作为抗病毒剂的5-取代的1-苯基-1,5-二氢-吡啶并[3,2-b]吲哚-2-酮及其类似物 |
US20070049603A1 (en) * | 2005-09-01 | 2007-03-01 | Greg Miknis | Raf inhibitor compounds and methods of use thereof |
EP2004647A1 (en) | 2006-04-03 | 2008-12-24 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 3,4-dihydro-imidazoý4,5-b¨pyridin-5-ones |
WO2008037783A1 (en) * | 2006-09-29 | 2008-04-03 | Tibotec Pharmaceuticals Ltd. | Process for preparing 2-oxo-2,5-dihydro-1h-pyrido[3,2-b]indole-3-carbonitriles |
WO2010115264A1 (en) | 2009-04-09 | 2010-10-14 | Boehringer Ingelheim International Gmbh | Inhibitors of hiv replication |
AU2011252351A1 (en) * | 2010-05-14 | 2012-10-11 | Affectis Pharmaceuticals Ag | Novel methods for the preparation of P2X7R antagonists |
EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
KR102435080B1 (ko) | 2016-07-19 | 2022-08-22 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 해충 방제제로서의 축합 바이시클릭 헤테로사이클 유도체 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
PH30929A (en) | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
RU2170082C2 (ru) | 1993-10-01 | 2001-07-10 | Астра Актиеболаг | Способ обработки лекарственного средства, устройство для формирования лекарственного средства и лекарственное средство |
US5612330A (en) * | 1994-03-07 | 1997-03-18 | Warner-Lambert Company | Methods for inhibiting and controlling viral growth |
CA2240161C (en) | 1996-05-20 | 2005-05-24 | Janssen Pharmaceutica N.V. | Antifungal compositions with improved bioavailability |
IL129575A (en) | 1997-03-26 | 2004-06-20 | Janssen Pharmaceutica Nv | Pills with a core coated with a fungicide and polymer |
US6596729B2 (en) * | 2000-07-20 | 2003-07-22 | Bristol-Myers Squibb Company | Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors |
WO2002059123A2 (en) * | 2000-12-18 | 2002-08-01 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Benzoylalkylindolepyridinium compounds and pharmaceutical compositions comprising such compounds |
US20020182151A1 (en) | 2000-12-18 | 2002-12-05 | The Government Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health & Human Services | Benzoylalkylindolepyridinium componds and pharmaceutical compositions comprising such compounds |
US20030096833A1 (en) | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
BR0316209A (pt) | 2002-11-15 | 2005-09-27 | Tibotec Pharm Ltd | Indolpiridìnio substituìdo como compostos antiinfecciosos |
-
2005
- 2005-05-17 MX MXPA06013314A patent/MXPA06013314A/es active IP Right Grant
- 2005-05-17 CN CN200580015818XA patent/CN1953983B/zh not_active Expired - Fee Related
- 2005-05-17 KR KR1020067025910A patent/KR20070015608A/ko not_active Application Discontinuation
- 2005-05-17 AP AP2006003791A patent/AP2006003791A0/xx unknown
- 2005-05-17 TW TW094116037A patent/TW200607503A/zh unknown
- 2005-05-17 EP EP05749219A patent/EP1758911A1/en not_active Withdrawn
- 2005-05-17 WO PCT/EP2005/052264 patent/WO2005111047A1/en active Application Filing
- 2005-05-17 JP JP2007517254A patent/JP4898668B2/ja not_active Expired - Fee Related
- 2005-05-17 CA CA002564027A patent/CA2564027A1/en not_active Abandoned
- 2005-05-17 AR ARP050102018A patent/AR049340A1/es not_active Application Discontinuation
- 2005-05-17 BR BRPI0511175-7A patent/BRPI0511175A/pt not_active IP Right Cessation
- 2005-05-17 AU AU2005243439A patent/AU2005243439B2/en not_active Ceased
- 2005-05-17 EA EA200602138A patent/EA012330B1/ru not_active IP Right Cessation
- 2005-05-17 US US11/568,845 patent/US7615639B2/en not_active Expired - Fee Related
-
2006
- 2006-10-15 IL IL178555A patent/IL178555A0/en unknown
- 2006-12-15 ZA ZA200610587A patent/ZA200610587B/xx unknown
- 2006-12-18 NO NO20065898A patent/NO20065898L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US7615639B2 (en) | 2009-11-10 |
CA2564027A1 (en) | 2005-11-24 |
AU2005243439B2 (en) | 2011-09-29 |
IL178555A0 (en) | 2007-02-11 |
MXPA06013314A (es) | 2007-02-02 |
AP2006003791A0 (en) | 2006-10-31 |
NO20065898L (no) | 2007-02-19 |
JP4898668B2 (ja) | 2012-03-21 |
TW200607503A (en) | 2006-03-01 |
CN1953983A (zh) | 2007-04-25 |
EP1758911A1 (en) | 2007-03-07 |
AR049340A1 (es) | 2006-07-19 |
WO2005111047A1 (en) | 2005-11-24 |
BRPI0511175A (pt) | 2007-12-04 |
EA012330B1 (ru) | 2009-08-28 |
US20070265295A1 (en) | 2007-11-15 |
KR20070015608A (ko) | 2007-02-05 |
AU2005243439A1 (en) | 2005-11-24 |
CN1953983B (zh) | 2010-05-26 |
JP2007538051A (ja) | 2007-12-27 |
ZA200610587B (en) | 2008-08-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |