EA200600714A1 - MEANS FOR THE TREATMENT OF EYE TUBERCULOSIS, METHOD OF ITS TREATMENT AND APPLICATION - Google Patents

MEANS FOR THE TREATMENT OF EYE TUBERCULOSIS, METHOD OF ITS TREATMENT AND APPLICATION

Info

Publication number
EA200600714A1
EA200600714A1 EA200600714A EA200600714A EA200600714A1 EA 200600714 A1 EA200600714 A1 EA 200600714A1 EA 200600714 A EA200600714 A EA 200600714A EA 200600714 A EA200600714 A EA 200600714A EA 200600714 A1 EA200600714 A1 EA 200600714A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
bis
eye
cystinyl
glycinate
Prior art date
Application number
EA200600714A
Other languages
Russian (ru)
Other versions
EA010926B1 (en
Inventor
Леонид Андреевич Кожемякин
Ольга Сергеевна Кетлинская
Валентина Михайловна Хокканен
Ольга Геннадьевна Ионова
Original Assignee
Леонид Андреевич Кожемякин
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Леонид Андреевич Кожемякин filed Critical Леонид Андреевич Кожемякин
Priority to EA200600714A priority Critical patent/EA010926B1/en
Priority to PCT/EA2006/000020 priority patent/WO2007082547A1/en
Publication of EA200600714A1 publication Critical patent/EA200600714A1/en
Publication of EA010926B1 publication Critical patent/EA010926B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к медицине, а именно к офтальмологии, и может быть использовано в комплексном лечении активных туберкулезных хориоретинитов, а также других заболеваний заднего отдела глаза, которые сопровождаются изменениями пигментного эпителия. Предложена энергизованная стабильная форма бис-(γ-L-глутамил)-L-цистинил-бис-глицината натрия с сохраняемой дисульфидной связью и способ ее получения, а также новый способ лечения заболеваний заднего отдела глаза, которые сопровождаются нарушением пигментного эпителия, в том числе активных туберкулезных хориоретинитов. Предложен способ получения энергизованной формы бис-(γ-L-глутамил)-L-цистинил-бис-глицината натрия. Способ лечения заболеваний заднего отдела глаза, которые сопровождаются нарушением пигментного эпителия, в том числе активных туберкулезных хориоретинитов, характеризующийся тем, что бис-(γ-L-глутамил)-L-цистинил-бис-глицината натрия применяют в монорежиме и/или в составе базовой специфической антибактериальной и противотуберкулезной химиотерапии в виде парабульбарных и/или подкожных, и/или внутримышечных инъекций ежедневно до получения терапевтического эффекта, но не менее 14 дней.The invention relates to medicine, namely to ophthalmology, and can be used in the complex treatment of active tuberculous chorioretinitis, as well as other diseases of the posterior part of the eye, which are accompanied by changes in pigment epithelium. An energized stable form of sodium bis (γ-L-glutamyl) -L-cystinyl-bis-glycinate with a retained disulfide bond and a method for its preparation, as well as a new method for the treatment of diseases of the posterior part of the eye, which are accompanied by a violation of the pigment epithelium, are proposed. active tuberculous chorioretinitis. A method for producing an energized form of sodium bis- (γ-L-glutamyl) -L-cystinyl-bis-glycinate is proposed. A method for the treatment of diseases of the posterior part of the eye, which are accompanied by a violation of pigment epithelium, including active tuberculous chorioretinitis, characterized in that sodium bis (γ-L-glutamyl) -L-cystinyl-bis-glycinate is used in mono mode and / or as part basic specific antibacterial and anti-tuberculosis chemotherapy in the form of parabulbar and / or subcutaneous, and / or intramuscular injections daily until a therapeutic effect is obtained, but not less than 14 days.

EA200600714A 2006-01-20 2006-01-20 Preparation for the treatment of ocular tuberculosis, method for preparation thereof and use EA010926B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EA200600714A EA010926B1 (en) 2006-01-20 2006-01-20 Preparation for the treatment of ocular tuberculosis, method for preparation thereof and use
PCT/EA2006/000020 WO2007082547A1 (en) 2006-01-20 2006-12-27 Eye tuberculosis treating agent and method for the production and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA200600714A EA010926B1 (en) 2006-01-20 2006-01-20 Preparation for the treatment of ocular tuberculosis, method for preparation thereof and use

Publications (2)

Publication Number Publication Date
EA200600714A1 true EA200600714A1 (en) 2007-08-31
EA010926B1 EA010926B1 (en) 2008-12-30

Family

ID=38287284

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600714A EA010926B1 (en) 2006-01-20 2006-01-20 Preparation for the treatment of ocular tuberculosis, method for preparation thereof and use

Country Status (2)

Country Link
EA (1) EA010926B1 (en)
WO (1) WO2007082547A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2089179C1 (en) * 1995-12-14 1997-09-10 Закрытое акционерное общество "ВАМ" Stimulator of cytokin and hemopoietic factors production and a method of its using
EP0957901B1 (en) * 1996-12-31 2009-11-18 Antioxidant Pharmaceuticals Corporation Pharmaceutical preparations of glutathione and methods of administration thereof
RU2144374C1 (en) * 1998-11-23 2000-01-20 Закрытое акционерное общество "ВАМ" Method of preparing of oxidized glutathione-cis- diaminodichloroplatinum complex and pharmaceutical compositions based on this complex for controlling metabolism, proliferation, and differentiation, and mechanisms of apoptosis of normal and transformated cells
US6312734B1 (en) * 1998-11-23 2001-11-06 Novelos Therapeutics, Inc. Methods for production of the oxidized glutathione composite with cis-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
RU2161982C1 (en) * 2000-01-20 2001-01-20 Общество с ограниченной ответственностью "Клиника Института биорегуляции и геронтологии" Tetrapeptide stimulating eye retina function, pharmacological agent based on thereof and method of its using
RU2177801C1 (en) * 2001-01-25 2002-01-10 Санкт-Петербургская Общественная Организация "Санкт-Петербургский Институт Биорегуляции И Геронтологии Сзо Рамн" Agent inhibiting angiogenesis in visual organ disease
RU2197984C1 (en) * 2001-11-14 2003-02-10 Закрытое акционерное общество "ВАМ-исследовательские лаборатории" Method for treating different forms of pulmonary tuberculosis, resistant to antitubercular chemotherapy, among them

Also Published As

Publication number Publication date
EA010926B1 (en) 2008-12-30
WO2007082547A1 (en) 2007-07-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AZ BY KZ TJ RU