EA200401355A1 - Применение циклопамина при лечении псориаза и других кожных заболеваний - Google Patents
Применение циклопамина при лечении псориаза и других кожных заболеванийInfo
- Publication number
- EA200401355A1 EA200401355A1 EA200401355A EA200401355A EA200401355A1 EA 200401355 A1 EA200401355 A1 EA 200401355A1 EA 200401355 A EA200401355 A EA 200401355A EA 200401355 A EA200401355 A EA 200401355A EA 200401355 A1 EA200401355 A1 EA 200401355A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cyclopamine
- treatment
- corticosteroid
- skin
- lesions
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Фармацевтические композиции, содержащие циклопамин, способствуют преодолению ингибирования дифференцировки клеток кожи. Такие композиции эффективны при лечении болезней, связанных с нарушенной клеточной дифференцировкой. В случае опухолей индукция дифференцировки опухолевых клеток циклопамином обычно сопровождается апоптозом опухолевых клеток, усиливая тем самым терапевтическую эффективность. Эффективность циклопамина при лечении псориаза, обычного заболевания, связанного с нарушением клеточной дифференцировки, значительно повышается при использовании композиций, состоящих из циклопамина и кортикостероида.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/TR2002/000017 WO2002078704A1 (en) | 2001-07-02 | 2002-04-19 | Use of cyclopamine in the treatment of psoriasis |
PCT/TR2003/000017 WO2003088964A1 (en) | 2002-04-19 | 2003-03-17 | Use of cyclopamine in the treatment of psoriasis and other skin disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200401355A1 true EA200401355A1 (ru) | 2005-06-30 |
Family
ID=29247069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200401355A EA200401355A1 (ru) | 2002-04-19 | 2003-03-17 | Применение циклопамина при лечении псориаза и других кожных заболеваний |
Country Status (15)
Country | Link |
---|---|
US (6) | US7605167B2 (ru) |
EP (2) | EP1411938B1 (ru) |
JP (1) | JP2006512281A (ru) |
KR (4) | KR20040102117A (ru) |
CN (2) | CN1835748A (ru) |
AT (1) | ATE309802T1 (ru) |
AU (1) | AU2003230541B2 (ru) |
BR (1) | BR0309396A (ru) |
CA (3) | CA2452152A1 (ru) |
DE (1) | DE60302348T2 (ru) |
DK (1) | DK1496895T3 (ru) |
EA (1) | EA200401355A1 (ru) |
ES (1) | ES2253672T3 (ru) |
MX (1) | MXPA04010294A (ru) |
WO (1) | WO2003088964A1 (ru) |
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US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
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CA2452152A1 (en) * | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
DK1401438T3 (da) * | 2001-07-02 | 2006-02-13 | Sinan Tas | Anvendelse af cyclopamin i behandlingen af basalt cellecarcinom og andre tumorer |
US20170326118A1 (en) * | 2001-07-02 | 2017-11-16 | Sinan Tas | Drug treatment of tumors wherein hedgehog/smoothened signaling is utilized for inhibition of apoptosis of tumor cells |
AU2005280112B2 (en) * | 2004-08-27 | 2012-07-19 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
WO2006039569A1 (en) * | 2004-09-30 | 2006-04-13 | The University Of Chicago | Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents |
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EP1945202A2 (en) * | 2005-11-11 | 2008-07-23 | Licentia OY | Mammalian hedgehog signaling inhiabitors |
US20080019961A1 (en) * | 2006-02-21 | 2008-01-24 | Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
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2002
- 2002-04-19 CA CA002452152A patent/CA2452152A1/en not_active Abandoned
- 2002-04-19 EP EP02736467A patent/EP1411938B1/en not_active Expired - Lifetime
-
2003
- 2003-03-17 CN CNA038087847A patent/CN1835748A/zh active Pending
- 2003-03-17 EA EA200401355A patent/EA200401355A1/ru unknown
- 2003-03-17 CN CN200910146214A patent/CN101642458A/zh active Pending
- 2003-03-17 MX MXPA04010294A patent/MXPA04010294A/es active IP Right Grant
- 2003-03-17 DE DE60302348T patent/DE60302348T2/de not_active Expired - Lifetime
- 2003-03-17 KR KR10-2004-7016679A patent/KR20040102117A/ko active Application Filing
- 2003-03-17 BR BR0309396-4A patent/BR0309396A/pt not_active IP Right Cessation
- 2003-03-17 WO PCT/TR2003/000017 patent/WO2003088964A1/en active IP Right Grant
- 2003-03-17 ES ES03723620T patent/ES2253672T3/es not_active Expired - Lifetime
- 2003-03-17 JP JP2003585716A patent/JP2006512281A/ja active Pending
- 2003-03-17 KR KR1020087024138A patent/KR20080096605A/ko not_active Application Discontinuation
- 2003-03-17 AU AU2003230541A patent/AU2003230541B2/en not_active Ceased
- 2003-03-17 KR KR1020087024137A patent/KR20080094739A/ko active Search and Examination
- 2003-03-17 DK DK03723620T patent/DK1496895T3/da active
- 2003-03-17 CA CA2636960A patent/CA2636960C/en not_active Expired - Fee Related
- 2003-03-17 AT AT03723620T patent/ATE309802T1/de not_active IP Right Cessation
- 2003-03-17 EP EP03723620A patent/EP1496895B1/en not_active Expired - Lifetime
- 2003-03-17 CA CA2481499A patent/CA2481499C/en not_active Expired - Fee Related
- 2003-03-17 KR KR1020077025034A patent/KR20070108287A/ko active Application Filing
- 2003-10-09 US US10/682,662 patent/US7605167B2/en not_active Expired - Fee Related
- 2003-10-09 US US10/682,584 patent/US7893078B2/en not_active Expired - Fee Related
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2007
- 2007-10-18 US US11/874,653 patent/US7629352B2/en not_active Expired - Fee Related
- 2007-10-18 US US11/874,631 patent/US8025893B2/en not_active Expired - Fee Related
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2009
- 2009-07-22 US US12/460,620 patent/US9757361B2/en not_active Expired - Fee Related
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2011
- 2011-01-13 US US12/930,677 patent/US20110104254A1/en not_active Abandoned
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