EA200400813A1 - Белок, имеющий в своей структуре цистиновые узлы - Google Patents
Белок, имеющий в своей структуре цистиновые узлыInfo
- Publication number
- EA200400813A1 EA200400813A1 EA200400813A EA200400813A EA200400813A1 EA 200400813 A1 EA200400813 A1 EA 200400813A1 EA 200400813 A EA200400813 A EA 200400813A EA 200400813 A EA200400813 A EA 200400813A EA 200400813 A1 EA200400813 A1 EA 200400813A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- nodes
- protein
- cystic
- proteins
- insp002
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 abstract 1
- 102000038900 DAN family Human genes 0.000 abstract 1
- 108091065053 DAN family Proteins 0.000 abstract 1
- 229960003067 cystine Drugs 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
Abstract
Настоящее изобретение относится к новому белку INSP002, идентифицированному в настоящей заявке как секретируемый белок, то есть как член семейства DAN, относящегося к суперсемейству цитокинов, имеющих в своей структуре цистиновые узлы, и к применению этого белка и последовательностей нуклеиновой кислоты кодирующих генов для диагностики, профилактики и лечения заболеваний.Отчет о международном поиске был опубликован 2003.08.28.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0130738.8A GB0130738D0 (en) | 2001-12-21 | 2001-12-21 | Protein |
| PCT/GB2002/005865 WO2003055911A2 (en) | 2001-12-21 | 2002-12-20 | Cystine-knot fold protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200400813A1 true EA200400813A1 (ru) | 2005-04-28 |
| EA007611B1 EA007611B1 (ru) | 2006-12-29 |
Family
ID=9928236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200400813A EA007611B1 (ru) | 2001-12-21 | 2002-12-20 | Белок, имеющий в своей структуре цистиновые узлы |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7619065B2 (ru) |
| EP (1) | EP1463754B1 (ru) |
| JP (1) | JP2005528336A (ru) |
| KR (1) | KR20040089093A (ru) |
| CN (1) | CN1620466A (ru) |
| AT (1) | ATE397624T1 (ru) |
| AU (1) | AU2002353207B2 (ru) |
| CA (1) | CA2470781A1 (ru) |
| DE (1) | DE60227002D1 (ru) |
| EA (1) | EA007611B1 (ru) |
| ES (1) | ES2306802T3 (ru) |
| GB (1) | GB0130738D0 (ru) |
| IL (2) | IL162592A0 (ru) |
| MX (1) | MXPA04006062A (ru) |
| WO (1) | WO2003055911A2 (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130738D0 (en) | 2001-12-21 | 2002-02-06 | Serono Internat S A | Protein |
| US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
| WO2005115439A2 (en) | 2004-05-27 | 2005-12-08 | Acceleron Pharma Inc. | Cerberus/coco derivatives and uses thereof |
| US9045553B2 (en) | 2004-05-27 | 2015-06-02 | Acceleron Pharma, Inc. | Cerberus/Coco derivatives and uses thereof |
| US20100048467A1 (en) * | 2006-01-12 | 2010-02-25 | Ares Trading S.A. | Cystine-Knot Fold Cytokine |
| AU2007332819A1 (en) | 2006-12-08 | 2008-06-19 | Acceleron Pharma Inc. | Uses of cerberus, coco and derivatives thereof |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| JP5458112B2 (ja) | 2009-02-03 | 2014-04-02 | コーニンクレッカ ネザーランド アカデミー ヴァン ウェテンシャッペン | 上皮幹細胞および該幹細胞を含むオルガノイドのための培養培地 |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| TWI799366B (zh) | 2015-09-15 | 2023-04-21 | 美商建南德克公司 | 胱胺酸結骨架平臺 |
| JP2020502218A (ja) | 2016-12-21 | 2020-01-23 | メレオ バイオファーマ ３ リミテッド | 骨形成不全症の処置における抗スクレロスチン抗体の使用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130738D0 (en) | 2001-12-21 | 2002-02-06 | Serono Internat S A | Protein |
| US7193069B2 (en) * | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
-
2001
- 2001-12-21 GB GBGB0130738.8A patent/GB0130738D0/en not_active Ceased
-
2002
- 2002-12-20 MX MXPA04006062A patent/MXPA04006062A/es not_active Application Discontinuation
- 2002-12-20 IL IL16259202A patent/IL162592A0/xx unknown
- 2002-12-20 CN CNA028282744A patent/CN1620466A/zh active Pending
- 2002-12-20 EP EP02788225A patent/EP1463754B1/en not_active Expired - Lifetime
- 2002-12-20 CA CA002470781A patent/CA2470781A1/en not_active Abandoned
- 2002-12-20 ES ES02788225T patent/ES2306802T3/es not_active Expired - Lifetime
- 2002-12-20 EA EA200400813A patent/EA007611B1/ru not_active IP Right Cessation
- 2002-12-20 AU AU2002353207A patent/AU2002353207B2/en not_active Ceased
- 2002-12-20 DE DE60227002T patent/DE60227002D1/de not_active Expired - Lifetime
- 2002-12-20 KR KR10-2004-7009759A patent/KR20040089093A/ko not_active Application Discontinuation
- 2002-12-20 AT AT02788225T patent/ATE397624T1/de not_active IP Right Cessation
- 2002-12-20 JP JP2003556441A patent/JP2005528336A/ja active Pending
- 2002-12-20 WO PCT/GB2002/005865 patent/WO2003055911A2/en active IP Right Grant
-
2004
- 2004-06-17 IL IL162592A patent/IL162592A/en not_active IP Right Cessation
- 2004-06-21 US US10/872,898 patent/US7619065B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7619065B2 (en) | 2009-11-17 |
| ES2306802T3 (es) | 2008-11-16 |
| CN1620466A (zh) | 2005-05-25 |
| GB0130738D0 (en) | 2002-02-06 |
| US20050186663A1 (en) | 2005-08-25 |
| CA2470781A1 (en) | 2003-07-10 |
| AU2002353207B2 (en) | 2009-01-08 |
| WO2003055911A2 (en) | 2003-07-10 |
| ATE397624T1 (de) | 2008-06-15 |
| WO2003055911A3 (en) | 2003-08-28 |
| WO2003055911A8 (en) | 2004-02-05 |
| EP1463754B1 (en) | 2008-06-04 |
| KR20040089093A (ko) | 2004-10-20 |
| DE60227002D1 (en) | 2008-07-17 |
| IL162592A (en) | 2009-12-24 |
| JP2005528336A (ja) | 2005-09-22 |
| EP1463754A2 (en) | 2004-10-06 |
| IL162592A0 (en) | 2005-11-20 |
| EA007611B1 (ru) | 2006-12-29 |
| AU2002353207A1 (en) | 2003-07-15 |
| MXPA04006062A (es) | 2004-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |