EA200400391A1 - Полиморфные формы производного 1-пиррола, промежуточного соединения для получения аторвастатина - Google Patents

Полиморфные формы производного 1-пиррола, промежуточного соединения для получения аторвастатина

Info

Publication number
EA200400391A1
EA200400391A1 EA200400391A EA200400391A EA200400391A1 EA 200400391 A1 EA200400391 A1 EA 200400391A1 EA 200400391 A EA200400391 A EA 200400391A EA 200400391 A EA200400391 A EA 200400391A EA 200400391 A1 EA200400391 A1 EA 200400391A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrol
polymorphic forms
derivative
atorvastatin
intermediate connection
Prior art date
Application number
EA200400391A
Other languages
English (en)
Other versions
EA007104B1 (ru
Inventor
Йожеф Баркоци
Дьюла Шимиг
Зольтан Грефф
Петер Котаи Надь
Жужа Сент Кирайи
Ференц Барта
Дьёрди Верецкейне Донат
Кальман Надь
Original Assignee
Эгиш Дьёдьсердьяр Рт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Рт. filed Critical Эгиш Дьёдьсердьяр Рт.
Publication of EA200400391A1 publication Critical patent/EA200400391A1/ru
Publication of EA007104B1 publication Critical patent/EA007104B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к новым кристаллическим формам I и II трет-бутилового эфира (4R-цис)-6-[2-[3-фенил-4-фенилкарбамоил-2-(4-фторфенил)-5-(1-метилэтил)пиррол-1-ил]этил]-2,2-диметил-[1,3]диоксан-4-ил-уксусной кислоты формулы (I) и способу их получения. Новые полиморфные формы настоящего изобретения являются полезными фармацевтическими промежуточными соединениями, которые могут быть использованы для получения ингибитора редуктазы гидроксиметилглютарилкоэнзима (ГМГ-КоА), имеющего МНН (международное непатентованное название) аторвастатин.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400391A 2001-09-14 2002-09-13 Полиморфные формы производного 1-пиррола, промежуточного соединения для получения аторвастатина EA007104B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0103702A HU227124B1 (en) 2001-09-14 2001-09-14 Polymorphs of 1-pyrrole derivative, intermediate for the preparation of atorvastatin
PCT/HU2002/000088 WO2003024959A1 (en) 2001-09-14 2002-09-13 Polymorphs of a 1-pyrrole derivative, intermediate for the preparation of atorvastatin

Publications (2)

Publication Number Publication Date
EA200400391A1 true EA200400391A1 (ru) 2005-02-24
EA007104B1 EA007104B1 (ru) 2006-06-30

Family

ID=89979680

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400391A EA007104B1 (ru) 2001-09-14 2002-09-13 Полиморфные формы производного 1-пиррола, промежуточного соединения для получения аторвастатина

Country Status (17)

Country Link
US (1) US7186848B2 (ru)
EP (1) EP1430049B1 (ru)
JP (1) JP2005505572A (ru)
KR (1) KR20040029482A (ru)
AT (1) ATE394393T1 (ru)
CY (1) CY1108235T1 (ru)
CZ (1) CZ2004469A3 (ru)
DE (1) DE60226463D1 (ru)
DK (1) DK1430049T3 (ru)
EA (1) EA007104B1 (ru)
ES (1) ES2306778T3 (ru)
HU (1) HU227124B1 (ru)
PL (1) PL217253B1 (ru)
PT (1) PT1430049E (ru)
SK (1) SK1722004A3 (ru)
UA (1) UA76496C2 (ru)
WO (1) WO2003024959A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050119270A1 (en) * 2000-08-04 2005-06-02 Mason R. P. Synergistic effect of amlodipine and atorvastatin on aortic endothelial cell nitric oxide release
JP2007517028A (ja) * 2003-12-29 2007-06-28 レツク・フアーマシユーテイカルズ・デー・デー 非晶質の（４ｒ−シス）−６−［２−［３−フェニル−４−（フェニルカルバモイル）−２−（４−フルオロフェニル）−５−（１−メチルエチル）−ピロール−１−イル］−エチル］−２，２−ジメチル−［１，３］−ジオキサン−４−イル−酢酸を調製する方法
WO2006032959A2 (en) * 2004-08-06 2006-03-30 Glenmark Pharmaceuticals Limited Processes for the preparation of pyrrole derivatives
KR101255204B1 (ko) * 2012-07-23 2013-04-23 주식회사 베프스 보안 기능을 갖는 저장 장치 리더기 및 이를 이용한 보안 방법
CN106938996B (zh) * 2016-01-05 2019-11-19 天方药业有限公司 一种阿托伐他汀钙中间体的制备方法
CN111362856B (zh) * 2020-04-29 2023-08-18 福建海西新药创制股份有限公司 一种利用微反应装置生产阿托伐他汀钙的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5103024A (en) * 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5217453A (en) * 1991-03-18 1993-06-08 Wilk Peter J Automated surgical system and apparatus
EP0688536B1 (de) * 1994-03-23 2000-08-02 Erbe Elektromedizin GmbH Multifunktionales Instrument für die Ultraschall-Chirurgie
US5526822A (en) * 1994-03-24 1996-06-18 Biopsys Medical, Inc. Method and apparatus for automated biopsy and collection of soft tissue
ES2167587T3 (es) * 1995-07-17 2002-05-16 Warner Lambert Co Forma cristalina de la sal hemicalcica del acido (r-(r*,r*))-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-((fenilamino)carbonil)-1h-pirrol-1-heptanoico (atorvastatina).
US5871495A (en) * 1996-09-13 1999-02-16 Eclipse Surgical Technologies, Inc. Method and apparatus for mechanical transmyocardial revascularization of the heart
SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina

Also Published As

Publication number Publication date
ATE394393T1 (de) 2008-05-15
US20040249168A1 (en) 2004-12-09
EP1430049A1 (en) 2004-06-23
DK1430049T3 (da) 2008-09-01
HU227124B1 (en) 2010-07-28
KR20040029482A (ko) 2004-04-06
UA76496C2 (ru) 2006-08-15
DE60226463D1 (de) 2008-06-19
SK1722004A3 (en) 2004-08-03
HUP0103702A3 (en) 2007-08-28
HUP0103702A2 (hu) 2003-06-28
EA007104B1 (ru) 2006-06-30
CY1108235T1 (el) 2014-02-12
EP1430049B1 (en) 2008-05-07
JP2005505572A (ja) 2005-02-24
PL217253B1 (pl) 2014-06-30
US7186848B2 (en) 2007-03-06
HU0103702D0 (en) 2001-11-28
PT1430049E (pt) 2008-08-08
WO2003024959A1 (en) 2003-03-27
CZ2004469A3 (cs) 2004-08-18
PL369227A1 (en) 2005-04-18
ES2306778T3 (es) 2008-11-16

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU