EA200100581A1 - COMBINATION OF ANALGETIC MEDICINES - Google Patents
COMBINATION OF ANALGETIC MEDICINESInfo
- Publication number
- EA200100581A1 EA200100581A1 EA200100581A EA200100581A EA200100581A1 EA 200100581 A1 EA200100581 A1 EA 200100581A1 EA 200100581 A EA200100581 A EA 200100581A EA 200100581 A EA200100581 A EA 200100581A EA 200100581 A1 EA200100581 A1 EA 200100581A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methyl
- analgesic
- compound
- analgin
- theobromine
- Prior art date
Links
- 230000000202 analgesic effect Effects 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title 1
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- GMSNIKWWOQHZGF-UHFFFAOYSA-N 3-methyl-9H-xanthine Chemical compound O=C1NC(=O)N(C)C2=C1N=CN2 GMSNIKWWOQHZGF-UHFFFAOYSA-N 0.000 abstract 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical group O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 2
- 229960001259 diclofenac Drugs 0.000 abstract 2
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 abstract 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 2
- DJGAAPFSPWAYTJ-UHFFFAOYSA-M metamizole sodium Chemical compound [Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 DJGAAPFSPWAYTJ-UHFFFAOYSA-M 0.000 abstract 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 2
- 229960004559 theobromine Drugs 0.000 abstract 2
- RYQVRAILJXPCMZ-UHFFFAOYSA-N 3-methyl-7-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]purine-2,6-dione Chemical compound O1C(C)=NC(CN2C=3C(=O)NC(=O)N(C)C=3N=C2)=N1 RYQVRAILJXPCMZ-UHFFFAOYSA-N 0.000 abstract 1
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 abstract 1
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N Aminoantipyrine Natural products CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 abstract 1
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 abstract 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 1
- 229960000212 aminophenazone Drugs 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 229960004126 codeine Drugs 0.000 abstract 1
- HEFNNWSXXWATRW-JTQLQIEISA-N dexibuprofen Chemical compound CC(C)CC1=CC=C([C@H](C)C(O)=O)C=C1 HEFNNWSXXWATRW-JTQLQIEISA-N 0.000 abstract 1
- OMFNSKIUKYOYRG-MOSHPQCFSA-N drotaverine Chemical compound C1=C(OCC)C(OCC)=CC=C1\C=C/1C2=CC(OCC)=C(OCC)C=C2CCN\1 OMFNSKIUKYOYRG-MOSHPQCFSA-N 0.000 abstract 1
- 229960002065 drotaverine Drugs 0.000 abstract 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
- 229960001680 ibuprofen Drugs 0.000 abstract 1
- 229960000905 indomethacin Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960005181 morphine Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Abstract
Настоящее изобретение относится к фармацевтической композиции, включающей в качестве активного ингредиента анальгетическое соединение и соединение ксантиновой структуры, в которой соотношение анальгетика и ксантинового производного составляет (1-20):1, предпочтительно 10:1. В качестве анальгетического соединения используют предпочтительно морфин, аминофеназон, анальгин, ацетилсалициловую кислоту, индометацин, ибупрофен, диклофенак, кодеин, более предпочтительно анальгин, S(+)ибупрофен, диклофенак; в качестве соединения ксантиновой структуры используют 3-метилксантин, теобромин или СН-13584 (1H-пурин-2,6-дион-3,7-дигидро-3-метил-7/5-метил-1,2,4-оксади-азол-2-ил/метил), предпочтительно теобромин. Композиции по настоящему изобретению могут содержать в качестве дополнительного активного ингредиента спазмолитик, предпочтительно дротаверин.Международная заявка была опубликована вместе с отчетом о международном поиске.The present invention relates to a pharmaceutical composition comprising as an active ingredient an analgesic compound and a compound of a xanthine structure, in which the ratio of analgesic to xanthine derivative is (1-20): 1, preferably 10: 1. As an analgesic compound, preferably morphine, aminophenazone, analgin, acetylsalicylic acid, indomethacin, ibuprofen, diclofenac, codeine, more preferably analgin, S (+) ibuprofen, diclofenac are used; 3-methylxanthine, theobromine or CH-13584 (1H-purine-2,6-dione-3,7-dihydro-3-methyl-7/5-methyl-1,2,4-oxadi- azol-2-yl / methyl), preferably theobromine. The compositions of the present invention may contain as an additional active ingredient an antispasmodic, preferably drotaverin. The international application has been published along with an international search report.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9802716A HUP9802716A3 (en) | 1998-11-25 | 1998-11-25 | Pharmaceutical composition of analgesic activity |
| PCT/HU1999/000079 WO2000030715A1 (en) | 1998-11-25 | 1999-11-23 | Composition containing an analgesic and a xanthine or a xanthine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200100581A1 true EA200100581A1 (en) | 2001-12-24 |
| EA004375B1 EA004375B1 (en) | 2004-04-29 |
Family
ID=89997413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200100581A EA004375B1 (en) | 1998-11-25 | 1999-11-23 | Composition containing analgetic medicaments |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1131135A1 (en) |
| AU (1) | AU1510200A (en) |
| BG (1) | BG105616A (en) |
| CZ (1) | CZ20011847A3 (en) |
| EA (1) | EA004375B1 (en) |
| EE (1) | EE200100281A (en) |
| HR (1) | HRP20010403A2 (en) |
| HU (1) | HUP9802716A3 (en) |
| PL (1) | PL348631A1 (en) |
| SK (1) | SK6872001A3 (en) |
| WO (1) | WO2000030715A1 (en) |
| YU (1) | YU37001A (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BG65576B1 (en) * | 2002-04-17 | 2009-01-30 | ПИРИМОВА Румяна | Composition of an analgesic, suitable in particular for headache and migraine |
| US10016437B2 (en) | 2009-06-16 | 2018-07-10 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| GB0919893D0 (en) * | 2009-11-13 | 2009-12-30 | Biocopea Ltd | Drug composition and its use in therapy |
| GB0910375D0 (en) | 2009-06-16 | 2009-07-29 | Biocopea Ltd | Drug composition and its use in therapy |
| US9308211B2 (en) | 2009-06-16 | 2016-04-12 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| US9314465B2 (en) | 2009-06-16 | 2016-04-19 | Infirst Healthcare Limited | Drug combinations and uses in treating a coughing condition |
| AU2015201845B2 (en) * | 2009-11-13 | 2015-11-05 | Infirst Healthcare Limited | Drug combination with theobromine and its use in therapy |
| WO2013005226A1 (en) * | 2011-07-04 | 2013-01-10 | Zota Health Care Ltd | A novel combined pharmaceutical composition containing diclofenac and methods of making and using the same |
| US8853189B2 (en) | 2012-05-31 | 2014-10-07 | Prima Innovations, Llc | Antispasmodic 1,2-Diols and 1,2,3-triols |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0205492A1 (en) * | 1984-12-26 | 1986-12-30 | SUNSHINE, Abraham | Analgesic, anti-inflammatory and skeletal muscle relaxant compositions |
| EP0719156A1 (en) * | 1993-09-07 | 1996-07-03 | The Procter & Gamble Company | Compositions containing an amino acid salt of propionic acid non-steroidal anti-inflammatory agent and at least one of a decongestant, an expectorant, an antihistamine and an antitussive |
| GB9613457D0 (en) * | 1996-06-27 | 1996-08-28 | Procter & Gamble | Pharmaceutical compositions |
-
1998
- 1998-11-25 HU HU9802716A patent/HUP9802716A3/en unknown
-
1999
- 1999-11-23 EP EP99957378A patent/EP1131135A1/en not_active Withdrawn
- 1999-11-23 EE EEP200100281A patent/EE200100281A/en unknown
- 1999-11-23 PL PL99348631A patent/PL348631A1/en unknown
- 1999-11-23 EA EA200100581A patent/EA004375B1/en not_active IP Right Cessation
- 1999-11-23 CZ CZ20011847A patent/CZ20011847A3/en unknown
- 1999-11-23 AU AU15102/00A patent/AU1510200A/en not_active Abandoned
- 1999-11-23 YU YU37001A patent/YU37001A/en unknown
- 1999-11-23 WO PCT/HU1999/000079 patent/WO2000030715A1/en not_active Application Discontinuation
- 1999-11-23 SK SK687-2001A patent/SK6872001A3/en unknown
-
2001
- 2001-05-25 HR HR20010403A patent/HRP20010403A2/en not_active Application Discontinuation
- 2001-06-18 BG BG105616A patent/BG105616A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1510200A (en) | 2000-06-13 |
| YU37001A (en) | 2004-05-12 |
| BG105616A (en) | 2002-01-31 |
| PL348631A1 (en) | 2002-06-03 |
| WO2000030715A1 (en) | 2000-06-02 |
| HU9802716D0 (en) | 1999-01-28 |
| EE200100281A (en) | 2002-08-15 |
| HUP9802716A2 (en) | 2000-06-28 |
| EP1131135A1 (en) | 2001-09-12 |
| SK6872001A3 (en) | 2002-05-09 |
| HUP9802716A3 (en) | 2000-08-28 |
| CZ20011847A3 (en) | 2002-07-17 |
| HRP20010403A2 (en) | 2002-06-30 |
| EA004375B1 (en) | 2004-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |