EA200000878A1 - SUBSTITUTE 1,2,4-TRIAZOLO [3,4-a] Pyridazine - Google Patents

SUBSTITUTE 1,2,4-TRIAZOLO [3,4-a] Pyridazine

Info

Publication number
EA200000878A1
EA200000878A1 EA200000878A EA200000878A EA200000878A1 EA 200000878 A1 EA200000878 A1 EA 200000878A1 EA 200000878 A EA200000878 A EA 200000878A EA 200000878 A EA200000878 A EA 200000878A EA 200000878 A1 EA200000878 A1 EA 200000878A1
Authority
EA
Eurasian Patent Office
Prior art keywords
triazolo
pyridazine
substitute
therapy
derivative
Prior art date
Application number
EA200000878A
Other languages
Russian (ru)
Other versions
EA002824B1 (en
Inventor
Вилльям Роберт Карлинг
Тамара Ладдувахетти
Ангус Мюррэй Маклеод
Кевин Джон Мерчант
Кевин Вилльям Мур
Фрэнсин Стернфелд
Лесли Джозеф Стрит
Original Assignee
Мерк Шарп Энд Домэ Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9803992.8A external-priority patent/GB9803992D0/en
Priority claimed from PCT/GB1998/001307 external-priority patent/WO1998050385A1/en
Priority claimed from GBGB9824896.6A external-priority patent/GB9824896D0/en
Application filed by Мерк Шарп Энд Домэ Лимитед filed Critical Мерк Шарп Энд Домэ Лимитед
Publication of EA200000878A1 publication Critical patent/EA200000878A1/en
Publication of EA002824B1 publication Critical patent/EA002824B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Описывается производное замещенного триазолопиридазина, его использование в терапии для повышения умственной способности, содержащие его композиции и способы его получения.Международная заявка была опубликована вместе с отчетом о международном поиске.A derivative of a substituted triazolopyridazine is described, its use in therapy to increase mental capacity, its compositions and methods for its preparation. The international application was published together with an international search report.

EA200000878A 1998-02-25 1999-02-17 Substituted 1,2,4-triazolo[3-4-a]pyridazine EA002824B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9803992.8A GB9803992D0 (en) 1998-02-25 1998-02-25 Therapeutic agents
PCT/GB1998/001307 WO1998050385A1 (en) 1997-05-08 1998-05-06 SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS
GBGB9824896.6A GB9824896D0 (en) 1998-11-12 1998-11-12 Therapeutic compound
PCT/GB1999/000485 WO1999043677A1 (en) 1998-02-25 1999-02-17 SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PYRIDAZINE

Publications (2)

Publication Number Publication Date
EA200000878A1 true EA200000878A1 (en) 2001-02-26
EA002824B1 EA002824B1 (en) 2002-10-31

Family

ID=27269184

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000878A EA002824B1 (en) 1998-02-25 1999-02-17 Substituted 1,2,4-triazolo[3-4-a]pyridazine

Country Status (14)

Country Link
EP (1) EP1070066A1 (en)
JP (1) JP2002504554A (en)
CN (1) CN1291194A (en)
AU (1) AU746719B2 (en)
BG (1) BG104705A (en)
CA (1) CA2317416A1 (en)
EA (1) EA002824B1 (en)
HR (1) HRP20000555A2 (en)
HU (1) HUP0100647A3 (en)
NZ (1) NZ505695A (en)
PL (1) PL341975A1 (en)
SK (1) SK12772000A3 (en)
TR (1) TR200002469T2 (en)
WO (1) WO1999043677A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9821179D0 (en) * 1998-09-30 1998-11-25 Merck Sharp & Dohme Therapeutic use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI81350C (en) * 1982-01-18 1990-10-10 Lepetit Spa ANALOGFOERFARANDE FOER FRAMSTAELLNING AV NYA, FARMAKOLOGISKT AKTIVA 6-SUBSTITUERADE S-TRIATSOLO / 3,4-A / PTHALAZINDERIVAT.
EP0915877A1 (en) * 1996-07-25 1999-05-19 MERCK SHARP & DOHME LTD. SUBSTITUTED TRIAZOLO PYRIDAZINE DERIVATIVES AS INVERSE AGONISTS OF THE GABA A?$g(a)5 RECEPTOR SUBTYPE
ATE221887T1 (en) * 1997-05-08 2002-08-15 Merck Sharp & Dohme SUBSTITUTED 1,2,4-TRIAZOLO(3,4,-A)PHTHALAZINE DERIVATIVES AS GABA-ALPHA 5 LIGANDS

Also Published As

Publication number Publication date
SK12772000A3 (en) 2001-03-12
HRP20000555A2 (en) 2001-08-31
EP1070066A1 (en) 2001-01-24
AU746719B2 (en) 2002-05-02
BG104705A (en) 2001-04-30
JP2002504554A (en) 2002-02-12
CN1291194A (en) 2001-04-11
CA2317416A1 (en) 1999-09-02
HUP0100647A2 (en) 2001-09-28
NZ505695A (en) 2002-03-01
AU2536899A (en) 1999-09-15
HUP0100647A3 (en) 2003-03-28
TR200002469T2 (en) 2000-12-21
PL341975A1 (en) 2001-05-07
EA002824B1 (en) 2002-10-31
WO1999043677A1 (en) 1999-09-02

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU