EA200000403A1 - Новые соединения, полезные в качестве нейропротекторов - Google Patents

Новые соединения, полезные в качестве нейропротекторов

Info

Publication number
EA200000403A1
EA200000403A1 EA200000403A EA200000403A EA200000403A1 EA 200000403 A1 EA200000403 A1 EA 200000403A1 EA 200000403 A EA200000403 A EA 200000403A EA 200000403 A EA200000403 A EA 200000403A EA 200000403 A1 EA200000403 A1 EA 200000403A1
Authority
EA
Eurasian Patent Office
Prior art keywords
protectors
neural
new connections
connections useful
useful
Prior art date
Application number
EA200000403A
Other languages
English (en)
Inventor
Бенджамин Алан Андерсон
Лоуренс Джозеф Хайнц
Джилл Энн Панетта
Майкл ЛеРой Филлипс
Джон Аллан Рик III
Джон Роберт Риццо
Джон Кевин Шэдл
Дэвид Ли Варье
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200000403A1 publication Critical patent/EA200000403A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Данное изобретение относится новым фенил-оксазолам, -тиазолам, -оксазолинам, -оксадиазолам и -бензоксазолам, полезным в качестве нейропротекторов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000403A 1997-10-06 1998-09-23 Новые соединения, полезные в качестве нейропротекторов EA200000403A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6101397P 1997-10-06 1997-10-06
PCT/US1998/019854 WO1999018091A1 (en) 1997-10-06 1998-09-23 Novel compounds useful as neuro-protective agents

Publications (1)

Publication Number Publication Date
EA200000403A1 true EA200000403A1 (ru) 2000-10-30

Family

ID=22033099

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000403A EA200000403A1 (ru) 1997-10-06 1998-09-23 Новые соединения, полезные в качестве нейропротекторов

Country Status (16)

Country Link
US (1) US6448396B2 (ru)
EP (1) EP0908454A3 (ru)
JP (1) JP2001519341A (ru)
KR (1) KR20010024402A (ru)
CN (1) CN1281442A (ru)
AU (1) AU9575698A (ru)
BR (1) BR9812857A (ru)
CA (1) CA2305538A1 (ru)
EA (1) EA200000403A1 (ru)
HU (1) HUP0004862A3 (ru)
ID (1) ID24564A (ru)
IL (1) IL135433A0 (ru)
NO (1) NO20001751L (ru)
PL (1) PL339673A1 (ru)
TR (2) TR200100352T2 (ru)
WO (1) WO1999018091A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE240728T1 (de) * 1996-10-07 2003-06-15 Lilly Co Eli Neue verbindungen nutlich als neuroschützende mittel
US6472387B1 (en) 1996-10-07 2002-10-29 Eli Lilly And Company Methods of using compounds as neuro-protective agents
TWI283577B (en) * 1999-10-11 2007-07-11 Sod Conseils Rech Applic Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
TWI248438B (en) * 2001-04-10 2006-02-01 Sod Conseils Rech Applic Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
US7179808B2 (en) 2002-07-03 2007-02-20 Janssen Pharmaceutica N.V. Substituted heteroaryl and heterocyclic compounds useful in treating inflammatory disorders
KR101799429B1 (ko) * 2010-05-03 2017-11-21 에스케이바이오팜 주식회사 신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물
CN103249726B (zh) * 2010-10-14 2015-01-07 第一三共株式会社 酰基苯衍生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636516A (en) 1981-02-19 1987-01-13 Yamanouchi Pharmaceutical Co., Ltd. 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds
DE3425118A1 (de) 1984-07-07 1986-01-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue redox-indikatoren
DE3621775A1 (de) 1986-03-13 1988-01-07 Thomae Gmbh Dr K Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4826990A (en) * 1987-09-30 1989-05-02 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
EP0382199A1 (en) 1989-02-08 1990-08-16 Takeda Chemical Industries, Ltd. Oxazole compounds and their use
ES2092580T3 (es) 1990-11-30 1996-12-01 Teijin Ltd Derivado de 2-ariltiazol y composicion farmaceutica que contiene el mismo.
US5633271A (en) 1992-05-26 1997-05-27 E. I. Du Pont De Nemours And Company Arthropodicidal oxazolines and thiazolines
DE4304197A1 (de) 1993-02-12 1994-08-18 Bayer Ag Substituierte Oxazole
US5428048A (en) 1993-11-08 1995-06-27 American Home Products Corporation Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents
US6251928B1 (en) 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
ATE240728T1 (de) * 1996-10-07 2003-06-15 Lilly Co Eli Neue verbindungen nutlich als neuroschützende mittel

Also Published As

Publication number Publication date
TR200001750T2 (tr) 2001-01-22
HUP0004862A3 (en) 2001-12-28
BR9812857A (pt) 2000-08-08
EP0908454A3 (en) 2001-07-25
IL135433A0 (en) 2001-05-20
PL339673A1 (en) 2001-01-02
AU9575698A (en) 1999-04-27
CA2305538A1 (en) 1999-04-15
NO20001751D0 (no) 2000-04-05
EP0908454A2 (en) 1999-04-14
TR200100352T2 (tr) 2001-06-21
US6448396B2 (en) 2002-09-10
HUP0004862A2 (hu) 2001-10-28
JP2001519341A (ja) 2001-10-23
CN1281442A (zh) 2001-01-24
US20010027194A1 (en) 2001-10-04
WO1999018091A1 (en) 1999-04-15
KR20010024402A (ko) 2001-03-26
ID24564A (id) 2000-07-27
NO20001751L (no) 2000-05-03

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