EA199800862A1 - Пептиды, обладающие антипролиферативными свойствами - Google Patents

Пептиды, обладающие антипролиферативными свойствами

Info

Publication number
EA199800862A1
EA199800862A1 EA199800862A EA199800862A EA199800862A1 EA 199800862 A1 EA199800862 A1 EA 199800862A1 EA 199800862 A EA199800862 A EA 199800862A EA 199800862 A EA199800862 A EA 199800862A EA 199800862 A1 EA199800862 A1 EA 199800862A1
Authority
EA
Eurasian Patent Office
Prior art keywords
peptides
owning
nucleic acids
growth factor
relates
Prior art date
Application number
EA199800862A
Other languages
English (en)
Inventor
Разван Т. Радулеску
Original Assignee
Разван Т. Радулеску
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Разван Т. Радулеску filed Critical Разван Т. Радулеску
Priority claimed from PCT/DE1997/000643 external-priority patent/WO1997035873A2/de
Publication of EA199800862A1 publication Critical patent/EA199800862A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к антипролиферативным пептидам, которые происходят от супрессорного по отношению к опухоли протеина и связываются с сегментами фактора роста или рецептора фактора роста. Далее, изобретение относится к нуклеиновым кислотам (ДНК/РНК), которые кодируют эти пептиды, а также к структурно гомологичным им пептидным нуклеиновым кислотам и фармацевтическим композициям, которые содержат пептиды. Изобретение находит применение в биотехнологии, молекулярной биологии, биоинформатике и при диагнозе и лечении гиперпролиферативных заболеваний, в особенности рака и атеросклероза.Отчет о международном поиске опубликован 1997.12.31.
EA199800862A 1996-03-26 1997-03-26 Пептиды, обладающие антипролиферативными свойствами EA199800862A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19611939 1996-03-26
DE19653445A DE19653445C1 (de) 1996-03-26 1996-12-20 Peptide mit antineoplastischen Eigenschaften
PCT/DE1997/000643 WO1997035873A2 (de) 1996-03-26 1997-03-26 Peptide mit antiproliferativen eigenschaften

Publications (1)

Publication Number Publication Date
EA199800862A1 true EA199800862A1 (ru) 1999-02-25

Family

ID=7789481

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800862A EA199800862A1 (ru) 1996-03-26 1997-03-26 Пептиды, обладающие антипролиферативными свойствами

Country Status (3)

Country Link
EP (1) EP0902088A3 (ru)
DE (2) DE19653445C1 (ru)
EA (1) EA199800862A1 (ru)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3038189A (en) * 1988-01-21 1989-08-11 Massachusetts Eye And Ear Infirmary Diagnosis of retinoblastoma
DE69126592T2 (de) * 1990-10-15 1998-01-08 Tecnogen Scpa Nicht-lineare Peptide, die hydropatisch komplementär zu bekannten Aminosäuresequenzen sind, Verfahren zur Herstellung und Verwendung davon
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
DE4237129A1 (de) * 1992-11-03 1994-05-05 Radulescu Razvan Tudor Dr Med Anwendung der Komplementärpeptid-Theorie in der Onkologie/Kartiologie: 1. VPH = NH¶2¶-len alphaN-Me-Phe Tyr Lys alphaN-Me-Lys Val D-Tyr-COOH 2. Kalziumantagonist auf der Basis eines Komplementärpeptides zur Calmodulinbindungsstelle 3.hSNI¶B¶¶1¶¶6¶¶-¶¶2¶¶1¶[3'->5'] = NH¶2¶-Len Pro Thr His Asp Ala-COOH
US5625031A (en) * 1994-02-08 1997-04-29 Bristol-Myers Squibb Company Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein
EP0685493A1 (en) * 1994-06-01 1995-12-06 CANJI, Inc. Tumor suppressor fusion proteins
WO1995034647A1 (en) * 1994-06-13 1995-12-21 Vanderbilt University Compositions for and methods of enhancing delivery of nucleic acids to cells
DE4432942A1 (de) * 1994-09-15 1996-03-21 Radulescu Razvan T Dr Med M D Synthetic Inducible Biological Response Amplifiers (SIBRAs) und ihre potentiellen Anwendungen in der Medizin
DE19526174C2 (de) * 1995-07-18 1998-02-26 Friedhelm Prof Dr Herrmann Mittel gegen Tumorwachstum

Also Published As

Publication number Publication date
EP0902088A2 (de) 1999-03-17
EP0902088A3 (de) 1999-09-15
DE19653445C1 (de) 1997-12-11
DE59709014D1 (de) 2003-01-30

Similar Documents

Publication Publication Date Title
BR9711795A (pt) Peptìdeos tendo propriedades antiproliferativas
RU95115239A (ru) Аналог эритропоэтина
FR19C1020I1 (fr) Nouvelles molecules b7-4 et leurs utilisations
DE69934967D1 (de) Verfahren zur verminderung der immunogenität von proteinen
JP4423542B2 (ja) 抗菌性ポリペプチド及びその利用
BR9206049A (pt) Composto, processos para preparar o composto, para o reconhecimento específico por sequência de um polinucleotídio de filamento duplo, para modular a expressão de um gene em um organismo, para tratar as condições associadas com produção de proteínas indesejada em um organismo, para induzir a degradação de DNA ou RNA em células de um organismo e para exterminar células ou vírus e composição farmacêutica
RU94046367A (ru) Днк, хозяйская клетка, способ получения белка, белок, фармацевтический препарат, антитело, применение антитела
FI925986A (fi) Slumpartat bio-oligomer bibliotek, ett foerfarande foer syntetisering avdet samt ett foerfarande foer anvaendning av det
DE69637148D1 (de) Nukleinsäuremoleküle, proteine und peptide, die im zusammenhang stehen mit dickdarmzellen und dickdarm-krebszellen
ATE380867T1 (de) Lactoferrinrezeptorgen von moraxella
ATE315087T1 (de) Neuartige auf p53 ansprechende gene
ATE300619T1 (de) Humane checkpointkinase, hcds1, zusammensetzungen und verfahren
ATE88500T1 (de) Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel.
FR2744455B1 (fr) Nouvelles sequences d'acides nucleiques de la famille des facteurs suppresseurs de tumeurs, produits d'expression correspondants et leurs applications
EP0815240A4 (en) NOVEL KINASE-LIKE CYCLINE-LIKE PROTEINS AND METHODS OF APPLICATION THEREOF
EA199800862A1 (ru) Пептиды, обладающие антипролиферативными свойствами
ES2145061T3 (es) Diagnostico y terapia a base de peptidos para el tratamiento de las espondiloartropatias.
DE60142356D1 (de) 18480 humane proteinkinasemoleküle und ihre verwendungen
NO874704L (no) Minaktivin fremstilt ved rekombinant dna-teknikk.
RU2002103164A (ru) Антибактериальный белок хламизин в, ген, кодирующий его, и экспрессирующая его система
EP1430070A4 (en) NOVEL CARK PROTEIN AND NUCLEIC ACID MOLECULES AND THEIR USE
ATE419350T1 (de) Humanes trp-ähnliches kalziumkanalprotein-2 tlcc- 2
EP1264843A3 (en) 38554, 57301 and 58324, Human organic ion transporters and uses therefor
WO2001042286A3 (en) Human leucine rich repeat-containing polypeptide and uses therefor
TH23725A (th) วัคซีนป้องกันโรคบิดสำหรับสัตว์ปีก