EA199800806A1 - СПОСОБ ИСТОЩЕНИЯ АДЕНОЗИН 5' - МОНОФОСФАТА В МЕТИЛТИОАДЕНОЗИНФОСФОРИЛАЗА (МТАза)-НЕДОСТАТОЧНЫХ КЛЕТКАХ МЛЕКОПИТАЮЩЕГО-ХОЗЯИНА - Google Patents

СПОСОБ ИСТОЩЕНИЯ АДЕНОЗИН 5' - МОНОФОСФАТА В МЕТИЛТИОАДЕНОЗИНФОСФОРИЛАЗА (МТАза)-НЕДОСТАТОЧНЫХ КЛЕТКАХ МЛЕКОПИТАЮЩЕГО-ХОЗЯИНА

Info

Publication number
EA199800806A1
EA199800806A1 EA199800806A EA199800806A EA199800806A1 EA 199800806 A1 EA199800806 A1 EA 199800806A1 EA 199800806 A EA199800806 A EA 199800806A EA 199800806 A EA199800806 A EA 199800806A EA 199800806 A1 EA199800806 A1 EA 199800806A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mtase
monophosphate
activity
loss
adenosine
Prior art date
Application number
EA199800806A
Other languages
English (en)
Other versions
EA001988B1 (ru
Inventor
Карлос Дж. Каррера
Деннис Э. Карсон
Говард Б. Коттэм
Цумото Нобори
Original Assignee
Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье filed Critical Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье
Publication of EA199800806A1 publication Critical patent/EA199800806A1/ru
Publication of EA001988B1 publication Critical patent/EA001988B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/963—Methods of stopping an enzyme reaction or stabilizing the test materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Представлен способ in vivo истощения аденозин 5'-монофосфата (АМФ) в клетках млекопитающих, применяемый при лечении определенных форм рака. В соответствии со способом популяцию клеток получают от хозяина и анализируют на утрату активности метилтиоаденозинфосфорилазы (МТАзы). МТАза расщепляет метилтиоаденозин до аденина для эндогенного использования его включения во внутриклеточный пул АМФ. Предпочтительным способом анализа утраты активности МТАзы является способ гибридизации с целью детекции гомозиготной утраты кодирующего гена с помощью терапевтически эффективного количества агента, который ингибирует активность аденилсукцинатсинтетазы, конвертирующей инозин 5'-монофосфат в АМФ, истощая таким образом субстраты опухолевых клеток для образования АМФ de novo. L-аланозин является предпочтительным ASS-ингибирующим агентом для использования в способе, соответствующем изобретению. На фиг. 1 представлена нуклеотидная последовательность геномной МТАзы (SEQ ID No 1), в которой подчеркнуты экзоны.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800806A 1996-03-08 1997-01-27 СПОСОБ ИСТОЩЕНИЯ АДЕНОЗИН 5'-МОНОФОСФАТА В МЕТИЛТИОАДЕНОЗИНФОСФОРИЛАЗА (МТАза)-НЕДОСТАТОЧНЫХ КЛЕТКАХ МЛЕКОПИТАЮЩЕГО-ХОЗЯИНА EA001988B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/612,542 US5840505A (en) 1993-12-29 1996-03-08 Method for inhibiting adenylosuccinate synthetase activity in methylthioadenosine phosphorylase deficient cells
PCT/US1997/001193 WO1997032994A1 (en) 1996-03-08 1997-01-27 Method for inhibiting adenylosuccinate synthetase activity methylthioadenosine phosphorylase deficient cells

Publications (2)

Publication Number Publication Date
EA199800806A1 true EA199800806A1 (ru) 1999-02-25
EA001988B1 EA001988B1 (ru) 2001-10-22

Family

ID=24453611

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800806A EA001988B1 (ru) 1996-03-08 1997-01-27 СПОСОБ ИСТОЩЕНИЯ АДЕНОЗИН 5'-МОНОФОСФАТА В МЕТИЛТИОАДЕНОЗИНФОСФОРИЛАЗА (МТАза)-НЕДОСТАТОЧНЫХ КЛЕТКАХ МЛЕКОПИТАЮЩЕГО-ХОЗЯИНА

Country Status (20)

Country Link
US (1) US5840505A (ru)
EP (1) EP0902839B1 (ru)
JP (1) JP2000509247A (ru)
KR (1) KR19990087627A (ru)
CN (1) CN1213406A (ru)
AT (1) ATE357223T1 (ru)
AU (1) AU722813B2 (ru)
BR (1) BR9708002A (ru)
CA (1) CA2244733A1 (ru)
CZ (1) CZ286698A3 (ru)
DE (1) DE69737499D1 (ru)
EA (1) EA001988B1 (ru)
HU (1) HUP9901858A3 (ru)
IL (1) IL126114A0 (ru)
NO (1) NO984124D0 (ru)
NZ (1) NZ331088A (ru)
PL (1) PL328810A1 (ru)
RO (1) RO118210B1 (ru)
UA (1) UA47465C2 (ru)
WO (1) WO1997032994A1 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210917B1 (en) * 1993-12-29 2001-04-03 The Regents Of The University Of California Method for suppressing multiple drug resistance in cancer cells
US6214571B1 (en) * 1993-12-29 2001-04-10 The Regents Of The University Of California Method for inhibiting adenylosuccinate synthetase activity in malignant methylthioadenosine phosphorylase deficient cells
US6911309B2 (en) * 1993-12-29 2005-06-28 The Regents Of The University Of Californnia Nucleic acids encoding MTAse
AU2001297765A1 (en) * 2000-12-05 2002-10-21 Incyte Genomics, Inc. Ligases
US20040043959A1 (en) * 2002-03-04 2004-03-04 Bloom Laura A. Combination therapies for treating methylthioadenosine phosphorylase deficient cells
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
EP1594900A2 (en) * 2003-02-14 2005-11-16 Salmedix, Inc. Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers
US20060041013A1 (en) * 2004-08-18 2006-02-23 Brittain Jason E Alanosine formulations and methods of use
WO2009014642A1 (en) * 2007-07-19 2009-01-29 Amgen Inc. Combination of a de novo purine biosynthesis inhibitor and a cyclin dependent kinase inhibitor for the treatment of cancer
CA3045752A1 (en) * 2016-12-01 2018-06-07 Glaxosmithkline Intellectual Property Development Limited Methods of treating cancer
JP7016958B2 (ja) * 2017-12-21 2022-02-07 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム アデノシンおよび／またはメチルチオアデノシンの酵素媒介枯渇方法
CN110124038A (zh) * 2019-05-08 2019-08-16 山东大学齐鲁医院 腺苷酸琥珀酸合成酶基因和/或其编码的蛋白的新应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792520A (en) * 1984-02-16 1988-12-20 University Of Cincinnati Methods and kits for identifying mutagenic agents and molecular mutations in DNA in mammalian cells
US4822736A (en) * 1984-07-05 1989-04-18 Baylor College Of Medicine Amplification of adenosine deaminase genes in mammalian cells using adenosine, alanosine, uridine, and deoxycoformycin
US5030623A (en) * 1986-03-27 1991-07-09 The Regents Of The University Of California Methods for increasing extracellular adenosine and for stabilizing mast cells
US5118601A (en) * 1986-03-27 1992-06-02 The Regents Of The University Of California Method of screening purine nucleoside compounds or analogs for the ability to enhance the cellular synthesis and release of adenosine
PL181667B1 (pl) * 1993-12-29 2001-08-31 Univ California Sposób wykrywania obecnosci katalitycznie aktywneji katalitycznie nieaktywnej fosforylazy metylotioadenozynowej (MTAzy), wyizolowany polinukleotyd oraz zrekombinowany wektor ekspresyjny PL

Also Published As

Publication number Publication date
RO118210B1 (ro) 2003-03-28
EA001988B1 (ru) 2001-10-22
NO984124L (no) 1998-09-07
IL126114A0 (en) 1999-05-09
CA2244733A1 (en) 1997-09-12
HUP9901858A3 (en) 1999-12-28
KR19990087627A (ko) 1999-12-27
EP0902839A1 (en) 1999-03-24
EP0902839A4 (en) 2004-06-30
DE69737499D1 (de) 2007-05-03
JP2000509247A (ja) 2000-07-25
HUP9901858A2 (hu) 1999-09-28
BR9708002A (pt) 1999-07-27
UA47465C2 (ru) 2002-07-15
CZ286698A3 (cs) 1999-03-17
AU1838897A (en) 1997-09-22
NZ331088A (en) 2000-08-25
PL328810A1 (en) 1999-02-15
CN1213406A (zh) 1999-04-07
US5840505A (en) 1998-11-24
AU722813B2 (en) 2000-08-10
ATE357223T1 (de) 2007-04-15
EP0902839B1 (en) 2007-03-21
WO1997032994A1 (en) 1997-09-12
NO984124D0 (no) 1998-09-07

Similar Documents

Publication Publication Date Title
Nelson et al. Allopurinol ribonucleoside as an antileishmanial agent
Olinski et al. Enigmatic 5-hydroxymethyluracil: Oxidatively modified base, epigenetic mark or both?
Wallace DNA damages processed by base excision repair: biological consequences
Kamiya Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: survey and summary
Lindahl Instability and decay of the primary structure of DNA
EA199800806A1 (ru) СПОСОБ ИСТОЩЕНИЯ АДЕНОЗИН 5' - МОНОФОСФАТА В МЕТИЛТИОАДЕНОЗИНФОСФОРИЛАЗА (МТАза)-НЕДОСТАТОЧНЫХ КЛЕТКАХ МЛЕКОПИТАЮЩЕГО-ХОЗЯИНА
Oses et al. Soluble NTPDase: an additional system of nucleotide hydrolysis in rat blood serum
Sekiguchi et al. A human enzyme that liberates uracil from DNA
US6713294B1 (en) DNA glycosylases and their use
HK1073660A1 (en) Methods and compositions and rna interference
Mattes et al. Excision of DNA adducts of nitrogen mustards by bacterial and mammalian 3-methyladenine-DNA glycosylases
PT1053313E (pt) Oligonucleotidos ''antisense'' optimizados complementares de sequencias de dna metiltransferase
Fram et al. Inhibition of DNA excision repair and the repair of X-ray-induced DNA damage by cytosine arabinoside and hydroxyurea
Browne et al. The sequence specificity of a mammalian DNA methylase
Rapaport et al. Relationship of the first step in protein synthesis to ppGpp: formation of A (5') ppp (5') Gpp.
Lönn et al. 5-Fluoropyrimidine-induced DNA damage in human colon adenocarcinoma and its augmentation by the nucleoside transport inhibitor dipyridamole
Kono et al. Substrate specificity of a thymidine phosphorylase in human liver tumor
Helland et al. Properties and mechanism of action of eukaryotic 3-methyladenine-DNA glycosylases
Meira et al. Base excision repair
Sano Subcellualr localizations of guanylate cyclase and 3′, 5′-cyclic nucleotide phophodiesterase in sea urchin sperm
Gerschenson et al. Levels of the mitochondrial endonuclease during rat cardiac development implicate a role for the enzyme in repair of oxidative damage in mitochondrial DNA
Igarashi et al. Organization and expression of the mouse MTH1 gene for preventing transversion mutation
Sano et al. Loss of chloroplast DNA methylation during dedifferentiation of Chlamydomonas reinhardi gametes
Charron et al. A third DNA polymerase from Spiroplasma citri and two other spiroplasmas
Otal-Brun et al. Uridine kinase activity in human tumors

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU