EA199700053A1 - Новые применения 2-[n-(1,2-бензизотиазолил-3(2h)он-1,1-диоксид]этил 5-этоксикарбонил-2,4,6-триметил-1,4-дигидропиридин-3-карбоксилата - Google Patents

Новые применения 2-[n-(1,2-бензизотиазолил-3(2h)он-1,1-диоксид]этил 5-этоксикарбонил-2,4,6-триметил-1,4-дигидропиридин-3-карбоксилата

Info

Publication number
EA199700053A1
EA199700053A1 EA199700053A EA199700053A EA199700053A1 EA 199700053 A1 EA199700053 A1 EA 199700053A1 EA 199700053 A EA199700053 A EA 199700053A EA 199700053 A EA199700053 A EA 199700053A EA 199700053 A1 EA199700053 A1 EA 199700053A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carboxylate
trimethyl
dioxide
ethyl
digydropyridin
Prior art date
Application number
EA199700053A
Other languages
English (en)
Inventor
Карлос Сункель Льетельер
Франсиско Хавьер Силльеро Корраль
Мигель Фау Де Касахуана Муньоз
Пилар Ортега Наваррете
Хайме Прьего Фернандез Дель Кампо
Луис Сантос Хиль
Original Assignee
Лабораториос Альтер, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лабораториос Альтер, С.А. filed Critical Лабораториос Альтер, С.А.
Publication of EA199700053A1 publication Critical patent/EA199700053A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В заявке описано новое применение 2-[N-(1,2-бензизотиазолил-3(2Н)он-1,1-диоксид]этил 5-этоксикарбонил-2,4,6-триметил-1,4-дигидропиридин-3-карбоксилата в качестве терапевтического средства для лечения пациентов, страдающих атеросклерозом и/или рестенозом, и пациентов, подверженных риску закупорки сосудов с патологическими изменениями. Это соединение может быть назначено для орального или парентерального введения в сочетании с другими лекарствами или без них для лечения пациентов, страдающих атеросклеротическими заболеваниями, с целью снижения атероматозного поражения и предотвращения рестеноза кровеносных сосудов.
EA199700053A 1995-08-25 1997-05-23 Новые применения 2-[n-(1,2-бензизотиазолил-3(2h)он-1,1-диоксид]этил 5-этоксикарбонил-2,4,6-триметил-1,4-дигидропиридин-3-карбоксилата EA199700053A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95500122A EP0771560A1 (en) 1995-08-25 1995-08-25 Use of 2- N-(1,2-benzoisothiazolyl-3(2H)one-1,1-dioxide ethyl 5-ethoxycarbonyl-2,4,6-trimethyl-1,4-dihydropiridine-3-carboxylate in the treatment of vascular disorders
PCT/ES1996/000160 WO1997007801A1 (es) 1995-08-25 1996-08-20 Nuevas aplicaciones del 5-etoxicarbonil-2,4,6-trimetil-1,4-dihidropiridina-3-carboxilato de 2-[n-(1,2-benzisotiazolil-3(2h)ona-1,1-dioxido]etilo

Publications (1)

Publication Number Publication Date
EA199700053A1 true EA199700053A1 (ru) 1997-12-30

Family

ID=8221657

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700053A EA199700053A1 (ru) 1995-08-25 1997-05-23 Новые применения 2-[n-(1,2-бензизотиазолил-3(2h)он-1,1-диоксид]этил 5-этоксикарбонил-2,4,6-триметил-1,4-дигидропиридин-3-карбоксилата

Country Status (12)

Country Link
EP (1) EP0771560A1 (ru)
JP (1) JPH10508879A (ru)
KR (1) KR970706817A (ru)
AU (1) AU6931496A (ru)
BR (1) BR9606691A (ru)
CA (1) CA2203624A1 (ru)
EA (1) EA199700053A1 (ru)
HU (1) HUP9701695A3 (ru)
IL (1) IL120718A0 (ru)
MX (1) MX9703032A (ru)
WO (1) WO1997007801A1 (ru)
ZA (1) ZA967223B (ru)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3617976A1 (de) * 1986-05-28 1988-01-14 Alter Sa 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten

Also Published As

Publication number Publication date
KR970706817A (ko) 1997-12-01
EP0771560A1 (en) 1997-05-07
ZA967223B (en) 1997-03-03
HUP9701695A2 (hu) 1998-03-30
AU6931496A (en) 1997-03-19
WO1997007801A1 (es) 1997-03-06
JPH10508879A (ja) 1998-09-02
CA2203624A1 (en) 1997-03-06
HUP9701695A3 (en) 1999-10-28
BR9606691A (pt) 2000-05-09
MX9703032A (es) 1997-12-31
IL120718A0 (en) 1997-08-14

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