EA037258B8 - Флагеллин-содержащие белковые наночастицы для иммуномодуляции - Google Patents

Флагеллин-содержащие белковые наночастицы для иммуномодуляции

Info

Publication number
EA037258B8
EA037258B8 EA201691202A EA201691202A EA037258B8 EA 037258 B8 EA037258 B8 EA 037258B8 EA 201691202 A EA201691202 A EA 201691202A EA 201691202 A EA201691202 A EA 201691202A EA 037258 B8 EA037258 B8 EA 037258B8
Authority
EA
Eurasian Patent Office
Prior art keywords
immunomodulation
flagellin
protein
nanoparticle according
containing protein
Prior art date
Application number
EA201691202A
Other languages
English (en)
Other versions
EA037258B1 (ru
EA201691202A1 (ru
Inventor
Питер Буркхард
Сентил Кумар Раман
Сара Мария Паулильо
Маттео Пьяцца
Кэролайн Кулангара
Кристиан Миттельхольцер
Original Assignee
Альфа-О Пептидс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Альфа-О Пептидс Аг filed Critical Альфа-О Пептидс Аг
Priority claimed from PCT/EP2015/050289 external-priority patent/WO2015104352A1/en
Publication of EA201691202A1 publication Critical patent/EA201691202A1/ru
Publication of EA037258B1 publication Critical patent/EA037258B1/ru
Publication of EA037258B8 publication Critical patent/EA037258B8/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

В изобретении предложены белковые наночастицы для иммуномодуляции, обладающие способностью самосборки, сконструированные из подходящих доменов олигомеризации и дополнительно включающие TLR5-связывающий белок флагеллин в качестве молекулы адъюванта. В настоящем изобретении также предложены композиция для иммуномодуляции, содержащая эффективное количество белковой наночастицы согласно настоящему изобретению, способ вакцинации человека, включающий введение белковой наночастицы согласно настоящему изобретению, и мономерный строительный блок для сборки наночастицы согласно настоящему изобретению.
EA201691202A 2014-10-16 2015-01-09 Флагеллин-содержащие белковые наночастицы для иммуномодуляции EA037258B8 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14189264 2014-10-16
PCT/EP2015/050289 WO2015104352A1 (en) 2014-01-09 2015-01-09 Flagellin-containing protein nanoparticles as a vaccine platform

Publications (3)

Publication Number Publication Date
EA201691202A1 EA201691202A1 (ru) 2017-01-30
EA037258B1 EA037258B1 (ru) 2021-02-26
EA037258B8 true EA037258B8 (ru) 2022-02-22

Family

ID=51798969

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691202A EA037258B8 (ru) 2014-10-16 2015-01-09 Флагеллин-содержащие белковые наночастицы для иммуномодуляции

Country Status (1)

Country Link
EA (1) EA037258B8 (ru)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013144579A1 (en) * 2012-03-30 2013-10-03 Heriot-Watt University Use of flagellin as a vaccine

Also Published As

Publication number Publication date
EA037258B1 (ru) 2021-02-26
EA201691202A1 (ru) 2017-01-30

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