EA036810B1 - Антитела к трансглютаминазе 2 - Google Patents

Антитела к трансглютаминазе 2 Download PDF

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Publication number
EA036810B1
EA036810B1 EA201492162A EA201492162A EA036810B1 EA 036810 B1 EA036810 B1 EA 036810B1 EA 201492162 A EA201492162 A EA 201492162A EA 201492162 A EA201492162 A EA 201492162A EA 036810 B1 EA036810 B1 EA 036810B1
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EA
Eurasian Patent Office
Prior art keywords
antibody
antigen
binding fragment
antibodies
fragment
Prior art date
Application number
EA201492162A
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English (en)
Russian (ru)
Other versions
EA201492162A1 (ru
Inventor
Тим Джонсон
Фил Уотсон
Дэвид Мэтьюз
Алекс Браун
Original Assignee
Медикал Рисёч Каунсэл Текнолоджи
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46546551&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA036810(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Медикал Рисёч Каунсэл Текнолоджи filed Critical Медикал Рисёч Каунсэл Текнолоджи
Publication of EA201492162A1 publication Critical patent/EA201492162A1/ru
Publication of EA036810B1 publication Critical patent/EA036810B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1075—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
EA201492162A 2012-05-24 2013-05-24 Антитела к трансглютаминазе 2 EA036810B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1209096.5A GB201209096D0 (en) 2012-05-24 2012-05-24 Compounds
PCT/GB2013/051373 WO2013175229A1 (en) 2012-05-24 2013-05-24 Anti -transglutaminase 2 antibodies

Publications (2)

Publication Number Publication Date
EA201492162A1 EA201492162A1 (ru) 2015-03-31
EA036810B1 true EA036810B1 (ru) 2020-12-23

Family

ID=46546551

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201492162A EA036810B1 (ru) 2012-05-24 2013-05-24 Антитела к трансглютаминазе 2

Country Status (39)

Country Link
US (3) US10005846B2 (https=)
EP (2) EP3521315B1 (https=)
JP (2) JP6411998B2 (https=)
KR (1) KR102091223B1 (https=)
CN (1) CN104321346B (https=)
AU (1) AU2013265025B2 (https=)
BR (1) BR112014029089B1 (https=)
CA (1) CA2874488C (https=)
CL (1) CL2014003125A1 (https=)
CO (1) CO7151528A2 (https=)
CY (2) CY1121932T1 (https=)
DK (2) DK2855530T3 (https=)
EA (1) EA036810B1 (https=)
EC (1) ECSP14030942A (https=)
ES (2) ES2835383T3 (https=)
GB (1) GB201209096D0 (https=)
HR (2) HRP20191293T1 (https=)
HU (2) HUE045539T2 (https=)
IL (1) IL235369B (https=)
IN (1) IN2014MN02231A (https=)
LT (2) LT3521315T (https=)
MA (1) MA37670B1 (https=)
ME (1) ME03393B (https=)
MX (1) MX367517B (https=)
MY (1) MY185966A (https=)
NZ (1) NZ701424A (https=)
PE (1) PE20150346A1 (https=)
PH (1) PH12014502582B1 (https=)
PL (2) PL2855530T3 (https=)
PT (2) PT2855530T (https=)
RS (2) RS59135B1 (https=)
SG (1) SG11201407053YA (https=)
SI (2) SI3521315T1 (https=)
SM (2) SMT201900407T1 (https=)
TN (1) TN2014000458A1 (https=)
TR (1) TR201906781T4 (https=)
UA (1) UA117657C2 (https=)
WO (1) WO2013175229A1 (https=)
ZA (1) ZA201408213B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110055235A (zh) * 2019-05-14 2019-07-26 深圳市亚辉龙生物科技股份有限公司 用于转谷氨酰胺酶抗体检测的抗原及其制备方法、试剂盒及检测方法
FR3117599B1 (fr) * 2020-12-16 2024-11-29 Oreal Méthode de pronostic et/ou de diagnostic d’un état pelliculaire du cuir chevelu
GB202115121D0 (en) 2021-10-21 2021-12-08 Ucb Biopharma Sprl Formulations
GB202115127D0 (en) 2021-10-21 2021-12-08 Ucb Biopharma Sprl Formulations
IL312800A (en) 2021-11-18 2024-07-01 UCB Biopharma SRL Method for the treatment of progressive chronic interstitial lung disease
GB202116665D0 (en) 2021-11-18 2022-01-05 UCB Biopharma SRL Method for the treatment of a scleroderma disease
GB202118010D0 (en) 2021-12-13 2022-01-26 UCB Biopharma SRL Method for detecting and/or quantifying crosslinks formed by transglutaminases
CN116515786B (zh) * 2023-04-26 2024-05-28 广东医科大学 一种人tgm3乙酰化多肽、抗原、抗体及其制备方法和应用
WO2025153465A1 (en) 2024-01-15 2025-07-24 UCB Biopharma SRL Method for the treatment of fibrotic-related disorder associated to ibd

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002068616A2 (en) * 2001-02-07 2002-09-06 Rsr Limited Tissue transglutaminase
WO2006100679A2 (en) * 2005-03-22 2006-09-28 Quark Pharmaceuticals, Inc. Recombinant antibodies against human type ii transglutaminase and uses thereof
WO2010113025A2 (en) * 2009-04-01 2010-10-07 University Of Debrecen Diagnosis of gluten-induced autoimmune diseases

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912120A (en) 1986-03-14 1990-03-27 Syntex (U.S.A.) Inc. 3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors
WO1992012238A1 (en) 1991-01-04 1992-07-23 The Board Of Regents, University Of Texas System Cloning and expression of tissue transglutaminases
WO1998004245A1 (en) 1996-07-25 1998-02-05 The Victoria University Of Manchester Use of transglutaminase modulators to promote wound healing
WO2004069175A2 (en) 2003-02-02 2004-08-19 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON’S DISEASE AND OTHER α-SYNUCLEINOPATHIES
GB0314262D0 (en) 2003-06-19 2003-07-23 Univ Nottingham Trent Novel compounds and methods of using the same
WO2008063760A2 (en) 2006-10-18 2008-05-29 The University Of Texas M.D. Anderson Cancer Center Methods for treating cancer targeting transglutaminase
CN102027013B (zh) * 2008-04-24 2015-01-14 株式会社遗传科技 细胞外基质蛋白的氨基酸序列rgd的特异性人源化抗体及其应用
EP2408471B1 (en) 2009-03-19 2015-06-24 Queensland University Of Technology Targets for growth factor signalling and methods of therapy
HU0900195D0 (en) 2009-04-01 2009-06-29 Debreceni Egyetem Diagnosis and treatment of gluten-induced autoimmune diseases
WO2011151395A2 (en) 2010-06-02 2011-12-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Transglutaminase 2 inhibitors for use in the prevention or treatment of rapidly progressive glomerulonephritis
GB2490655A (en) 2011-04-28 2012-11-14 Univ Aston Modulators of tissue transglutaminase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002068616A2 (en) * 2001-02-07 2002-09-06 Rsr Limited Tissue transglutaminase
WO2006100679A2 (en) * 2005-03-22 2006-09-28 Quark Pharmaceuticals, Inc. Recombinant antibodies against human type ii transglutaminase and uses thereof
WO2010113025A2 (en) * 2009-04-01 2010-10-07 University Of Debrecen Diagnosis of gluten-induced autoimmune diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CACCAMO DANIELA; CURRÒ MONICA; IENTILE RICCARDO: "Potential of transglutaminase 2 as a therapeutic target.", EXPERT OPINION ON THERAPEUTIC TARGETS, INFORMA HEALTHCARE, GB, vol. 14, no. 9, 1 September 2010 (2010-09-01), GB, pages 989 - 1003, XP009172074, ISSN: 1744-7631, DOI: 10.1517/14728222.2010.510134 *
DI NIRO ROBERTO; ZILLER FEDERICA; FLORIAN FIORELLA; CROVELLA SERGIO; STEBEL MARCO; BESTAGNO MARCO; BURRONE OSCAR; BRADBURY ANDREW : "Construction of miniantibodies for the in vivo study of human autoimmune diseases in animal models", BMC BIOTECHNOLOGY, BIOMED CENTRAL LTD, vol. 7, no. 1, 1 August 2007 (2007-08-01), pages 46, XP021029486, ISSN: 1472-6750, DOI: 10.1186/1472-6750-7-46 *
N.N.: "Anti-transglutaminase 2 antibody [CUB 7402] (ab2386), Abcam-Data sheet, 2010, XP002711958, Retrieved from the Internet: URL:http://www.abcam.com/transglutaminase-2-antibody-cub-7402-ab2386.html [retrieved on 2013-08-27] page 1 *
ROBERTO DI�NIRO, FORTUNATO FERRARA, TARCISIO NOT, ANDREW�R.�M. BRADBURY, FERNANDO CHIRDO, ROBERTO MARZARI, DANIELE SBLATTERO: "Characterizing monoclonal antibody epitopes by filtered gene fragment phage display", BIOCHEMICAL JOURNAL, PUBLISHED BY PORTLAND PRESS ON BEHALF OF THE BIOCHEMICAL SOCIETY., vol. 388, no. 3, 15 June 2005 (2005-06-15), pages 889 - 894, XP055076637, ISSN: 02646021, DOI: 10.1042/BJ20041983 *
T.-S. LAI, Y. LIU, W. LI, C. S. GREENBERG: "Identification of two GTP-independent alternatively spliced forms of tissue transglutaminase in human leukocytes, vascular smooth muscle, and endothelial cells", THE FASEB JOURNAL, THE FEDERATION, vol. 21, no. 14, 20 July 2007 (2007-07-20), pages 4131 - 4143, XP055076665, ISSN: 08926638, DOI: 10.1096/fj.06-7598com *

Also Published As

Publication number Publication date
HUE052490T2 (hu) 2021-04-28
AU2013265025A1 (en) 2014-12-04
SMT202100014T1 (it) 2021-03-15
EP2855530A1 (en) 2015-04-08
PL2855530T3 (pl) 2019-10-31
CA2874488C (en) 2021-09-07
PE20150346A1 (es) 2015-03-05
SI2855530T1 (sl) 2019-08-30
AU2013265025B2 (en) 2018-04-26
JP2015519897A (ja) 2015-07-16
CO7151528A2 (es) 2014-12-29
NZ701424A (en) 2016-08-26
EP2855530B1 (en) 2019-05-01
JP6411998B2 (ja) 2018-10-24
MX2014014264A (es) 2015-05-15
BR112014029089A2 (pt) 2019-06-25
US20210101999A1 (en) 2021-04-08
IL235369B (en) 2019-05-30
CL2014003125A1 (es) 2015-08-21
PH12014502582A1 (en) 2015-01-21
JP2018166510A (ja) 2018-11-01
CA2874488A1 (en) 2013-11-28
UA117657C2 (uk) 2018-09-10
CY1123926T1 (el) 2022-05-27
US20150218289A1 (en) 2015-08-06
BR112014029089B1 (pt) 2023-04-25
US10961319B2 (en) 2021-03-30
MA37670A1 (fr) 2016-05-31
ECSP14030942A (es) 2015-09-30
ME03393B (me) 2020-01-20
MX367517B (es) 2019-08-26
WO2013175229A1 (en) 2013-11-28
DK2855530T3 (da) 2019-06-24
PH12014502582B1 (en) 2015-01-21
CY1121932T1 (el) 2020-10-14
CN104321346A (zh) 2015-01-28
PT3521315T (pt) 2020-10-29
KR102091223B1 (ko) 2020-03-20
MY185966A (en) 2021-06-14
PL3521315T3 (pl) 2021-08-23
EP3521315A1 (en) 2019-08-07
IL235369A0 (en) 2014-12-31
SI3521315T1 (sl) 2020-12-31
GB201209096D0 (en) 2012-07-04
HRP20202059T1 (hr) 2021-02-19
IN2014MN02231A (https=) 2015-07-24
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HK1203974A1 (en) 2015-11-06
DK3521315T3 (da) 2020-11-09
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PT2855530T (pt) 2019-07-08
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US20180355060A1 (en) 2018-12-13
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EA201492162A1 (ru) 2015-03-31
US10005846B2 (en) 2018-06-26
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TR201906781T4 (tr) 2019-05-21

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