EA035620B1 - Способы и композиция для лечения или профилактики катаракты - Google Patents

Способы и композиция для лечения или профилактики катаракты Download PDF

Info

Publication number
EA035620B1
EA035620B1 EA201790361A EA201790361A EA035620B1 EA 035620 B1 EA035620 B1 EA 035620B1 EA 201790361 A EA201790361 A EA 201790361A EA 201790361 A EA201790361 A EA 201790361A EA 035620 B1 EA035620 B1 EA 035620B1
Authority
EA
Eurasian Patent Office
Prior art keywords
lutein
polymer
nanoparticles
moreover
cornea
Prior art date
Application number
EA201790361A
Other languages
English (en)
Russian (ru)
Other versions
EA201790361A1 (ru
Inventor
Кристина М. Сабилов
Карлос Э. Астете
Еде Бодоки
Оливиу Востинару
Овидиу Чипрьян Самойла
Елена Динте
Original Assignee
Борд Оф Сьюпервайзорз Оф Луизиана Стэйт Юниверсити Энд Эгрикалчурал Энд Мекэникал Колледж
Юлию Хацьегану Юниверсити Оф Медсин Энд Фармеси
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Борд Оф Сьюпервайзорз Оф Луизиана Стэйт Юниверсити Энд Эгрикалчурал Энд Мекэникал Колледж, Юлию Хацьегану Юниверсити Оф Медсин Энд Фармеси filed Critical Борд Оф Сьюпервайзорз Оф Луизиана Стэйт Юниверсити Энд Эгрикалчурал Энд Мекэникал Колледж
Publication of EA201790361A1 publication Critical patent/EA201790361A1/ru
Publication of EA035620B1 publication Critical patent/EA035620B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201790361A 2014-08-11 2015-08-10 Способы и композиция для лечения или профилактики катаракты EA035620B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462035683P 2014-08-11 2014-08-11
US201562172455P 2015-06-08 2015-06-08
PCT/US2015/044483 WO2016025394A2 (en) 2014-08-11 2015-08-10 Delivery of bioactive, nanoencapsulated antioxidants

Publications (2)

Publication Number Publication Date
EA201790361A1 EA201790361A1 (ru) 2017-06-30
EA035620B1 true EA035620B1 (ru) 2020-07-16

Family

ID=55304745

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790361A EA035620B1 (ru) 2014-08-11 2015-08-10 Способы и композиция для лечения или профилактики катаракты

Country Status (12)

Country Link
US (2) US10292943B2 (forum.php)
EP (1) EP3179988A4 (forum.php)
JP (1) JP6668327B2 (forum.php)
KR (1) KR102218883B1 (forum.php)
AP (1) AP2017009684A0 (forum.php)
AU (1) AU2015301945B2 (forum.php)
BR (1) BR112017002580A2 (forum.php)
CA (1) CA2992879C (forum.php)
EA (1) EA035620B1 (forum.php)
MX (1) MX388028B (forum.php)
WO (1) WO2016025394A2 (forum.php)
ZA (1) ZA201700987B (forum.php)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3179988A4 (en) * 2014-08-11 2018-11-14 Board of Supervisors of Lousiana State University Delivery of bioactive, nanoencapsulated antioxidants
WO2019148140A2 (en) * 2018-01-26 2019-08-01 Wu Joseph C Implantable biomaterials that enhance stem cell survival and function
CA3174213A1 (en) * 2019-06-14 2020-12-17 Daniela Oana Trambitas Method for micro-encapsulation of natural ingredients by means of contacting with supercritical gas
CA3181943A1 (en) * 2020-05-11 2021-11-18 Op2Lysis Slow release plasminogen activator formulation for use in the treatment of thrombotic or haemorrhagic disease
US11253481B1 (en) 2021-07-12 2022-02-22 King Abdulaziz University Self-nanoemulsifying 3D-printed tablet composition and method of use thereof
US11298321B1 (en) 2021-07-12 2022-04-12 King Abdulaziz University Methods for treating metabolic disorder
KR102824097B1 (ko) 2022-12-07 2025-06-24 주식회사 엘지생활건강 바이오틴이 담지된 나노파티클 및 이의 제조 방법, 및 이의 용도
WO2025106389A1 (en) * 2023-11-13 2025-05-22 Universitatea De Medicină Şi Farmacie Iluiu Haţieganu New forms of lutein and their uses

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6573299B1 (en) * 1999-09-20 2003-06-03 Advanced Medical Instruments Method and compositions for treatment of the aging eye
US20100112073A1 (en) * 2007-05-07 2010-05-06 Sabliov Cristina M Water-Soluble Nanoparticles Containing Water-Insoluble Compounds
US20120231072A1 (en) * 2011-03-11 2012-09-13 Chemisches Institut Schaefer Ag Thermo-responsive hydrogel compositions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2011423A1 (en) * 1989-03-07 1990-09-07 Peter M. Taylor Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings
US6703039B2 (en) * 2000-12-06 2004-03-09 Bausch & Lomb Incorporated Reversible gelling system for ocular drug delivery
DE10141018A1 (de) * 2001-08-22 2003-03-13 Eth Zuerich Eidgenoessische Te Verwendung von negativ geladenen Phospholipiden, sowie Zusammensetzungen umfassend Phospholipide zur Behandlung des Auges
US20040009212A1 (en) 2002-01-30 2004-01-15 Pharma Power Biotec Co. Ltd. Mucoadhesive thermoresponsive medicament-carrier composition
JP4448441B2 (ja) 2002-06-05 2010-04-07 ユニヴァーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド 眼科用医薬のデリバリーシステム
JP2009515821A (ja) * 2005-10-16 2009-04-16 リコレッド リミテッド 眼疾患を治療するための組成物
ES2724176T3 (es) 2010-07-16 2019-09-06 Univ Navarra Nanopartículas para encapsulación de compuestos, su obtención y usos
JP5829685B2 (ja) 2010-09-03 2015-12-09 サンテン・エス・エー・エス 眼の疾患を処置するための油中水型エマルション
JP2014515007A (ja) * 2011-02-25 2014-06-26 サウス ダコタ ステート ユニバーシティー 局所送達のためのタンパク質ナノ担体
CN103845278B (zh) * 2012-11-30 2016-06-22 沈阳药科大学 一种叶黄素眼用纳米乳-温度敏感型原位凝胶及其制备方法
EP3179988A4 (en) * 2014-08-11 2018-11-14 Board of Supervisors of Lousiana State University Delivery of bioactive, nanoencapsulated antioxidants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6573299B1 (en) * 1999-09-20 2003-06-03 Advanced Medical Instruments Method and compositions for treatment of the aging eye
US20100112073A1 (en) * 2007-05-07 2010-05-06 Sabliov Cristina M Water-Soluble Nanoparticles Containing Water-Insoluble Compounds
US20120231072A1 (en) * 2011-03-11 2012-09-13 Chemisches Institut Schaefer Ag Thermo-responsive hydrogel compositions

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAGHAEI B. et al. "Novel thermosensitive hydrogel composites based on poly (d,l-lactide-co-glycolide) nanoparticles embedded in poly (n-isopropyl acrylamide) with sustained drug-release behavior." Journal of Applied Polymer Science, March 2014, Vol. 131, No.16; entire document *
HAO J. et al. "Fabrication of a composite system combining solid lipid nanoparticles and thermosensitive hydrogel for challenging ophthalmic drug delivery." Colloids and Surfaces B: Biointerfaces, October 2013, Vol. 114, pages 111-120 *
HU D. et al. "Preparation, characterization, and in vitro release investigation of lutein/zein nanoparticles via solution enhanced dispersion by supercritical fluids." Journal of Food Engineering, 2012, Vol. 109. No. 3; abstract; page 545 *
LOU J. et al. "Optimization and evaluation of a thermoresponsive ophthalmic in situ gel containing curcumin-loaded albumin nanoparticles." International Journal of Nanomedicine. May 2014, Vol. 9; abstract; pages 2518, 2520-2522 *

Also Published As

Publication number Publication date
AU2015301945A1 (en) 2017-03-09
AU2015301945B2 (en) 2020-05-14
EP3179988A4 (en) 2018-11-14
EP3179988A2 (en) 2017-06-21
US10952974B2 (en) 2021-03-23
US20190254987A1 (en) 2019-08-22
WO2016025394A3 (en) 2016-05-19
KR20170097601A (ko) 2017-08-28
US20170216221A1 (en) 2017-08-03
CA2992879C (en) 2022-10-25
US10292943B2 (en) 2019-05-21
MX2017001903A (es) 2017-09-26
JP2017523983A (ja) 2017-08-24
JP6668327B2 (ja) 2020-03-18
CA2992879A1 (en) 2016-02-18
AP2017009684A0 (forum.php) 2017-01-31
BR112017002580A2 (pt) 2018-03-27
EA201790361A1 (ru) 2017-06-30
KR102218883B1 (ko) 2021-02-23
MX388028B (es) 2025-03-19
ZA201700987B (en) 2019-05-29
WO2016025394A2 (en) 2016-02-18

Similar Documents

Publication Publication Date Title
US10952974B2 (en) Delivery of bioactive, nanoencapsulated antioxidants
Flamminii et al. Structuring alginate beads with different biopolymers for the development of functional ingredients loaded with olive leaves phenolic extract
Dai et al. Structural characterization, formation mechanism and stability of curcumin in zein-lecithin composite nanoparticles fabricated by antisolvent co-precipitation
JP7584421B2 (ja) 大環状ラクトン製剤、その調製方法、及び眼部寄生虫に続発する症状の治療における該製剤の使用
Ramteke et al. Clarithromycin based oral sustained release nanoparticulate drug delivery system
JP7390738B2 (ja) キトサンでコートされたナノカプセル及びその用途
Sumathi et al. Formulation and evaluation of polymeric nanosuspension of naringenin
US11191750B2 (en) Use of mTOR inhibitors for treatment of familial adenomatous polyposis
Deshmukh et al. Chitosan-vitamin C nanoparticles
JP2003500435A (ja) 抗感染剤および／または抗炎症剤を適用するための製剤
İmamoğlu et al. Effect of surfactant types and concentrations on levofloxacin-loaded PLGA microparticles for pulmonary delivery–An in vitro study
WO2018167179A1 (en) Oil-free carotenoid composition
CN102188379B (zh) 载药脂质体的制备方法
JP5811421B2 (ja) 保存効力を示す非水性油性注射用製剤
WO2015006735A1 (en) Nanoparticles and methods of producing the same
Thamrook et al. Applications of lipid Core Nanocapsules: novel drug delivery system
KR101771483B1 (ko) 루테인의 용출률 및 안정성이 개선된 이중층 구조의 고분자 캡슐, 이의 제조방법 및 이를 함유하는 안과질환 예방 또는 치료용 약제학적 조성물
KR20210031555A (ko) 레티놀 또는 레티놀 유도체를 포함하는 키토산이 코팅된 나노캡슐 및 이의 용도
CN116602959B (zh) 一种具有抗炎镇痛功效的含茶活性成分的组合物脂质体及其应用
CN104116706B (zh) 一种丙酮酸乙酯滴眼液及其制备方法
Cosby Preclinical Delivery of Fractionated Black Raspberry Phytochemicals to Oral Epithelial Cells Using Lipid and Polymer Nanoparticles
Gad et al. Employment of Squash-synthesized Nanoselenium and Chitosan as Nanocomposites for Delivering Insulin
Truong Development and Evaluation of Quercetin Nanoparticles and Hot Melt Cast Films for Retinal Neuroprotection
CN120093886A (zh) 基于多模态靶向递送延缓视力下降的营养组合物及制备方法
Colaço Development of nanosized glucan particles with immunostimulatory function as a delivery syistem for curcumin