EA035336B1 - Способ лечения связанного со старением когнитивного расстройства или заболевания - Google Patents
Способ лечения связанного со старением когнитивного расстройства или заболевания Download PDFInfo
- Publication number
- EA035336B1 EA035336B1 EA201690969A EA201690969A EA035336B1 EA 035336 B1 EA035336 B1 EA 035336B1 EA 201690969 A EA201690969 A EA 201690969A EA 201690969 A EA201690969 A EA 201690969A EA 035336 B1 EA035336 B1 EA 035336B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- plasma
- young
- aging
- blood
- disease
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361913812P | 2013-12-09 | 2013-12-09 | |
US201462069044P | 2014-10-27 | 2014-10-27 | |
PCT/US2014/068897 WO2015088915A1 (fr) | 2013-12-09 | 2014-12-05 | Méthodes et compositions pour traiter des états associés au vieillissement |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201690969A1 EA201690969A1 (ru) | 2016-09-30 |
EA035336B1 true EA035336B1 (ru) | 2020-05-29 |
Family
ID=53270052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690969A EA035336B1 (ru) | 2013-12-09 | 2014-12-05 | Способ лечения связанного со старением когнитивного расстройства или заболевания |
Country Status (13)
Country | Link |
---|---|
US (2) | US10688130B2 (fr) |
EP (1) | EP3079708A4 (fr) |
JP (2) | JP6667438B2 (fr) |
KR (2) | KR102351604B1 (fr) |
CN (1) | CN106163530A (fr) |
AU (1) | AU2014364182B2 (fr) |
BR (1) | BR112016012968A2 (fr) |
CA (1) | CA2933440A1 (fr) |
EA (1) | EA035336B1 (fr) |
IL (1) | IL246023B (fr) |
MX (1) | MX2016007492A (fr) |
NZ (1) | NZ720949A (fr) |
WO (1) | WO2015088915A1 (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10487148B2 (en) | 2010-01-28 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating aging-associated impairments |
WO2017120461A1 (fr) | 2016-01-08 | 2017-07-13 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation du ccr3 pour le traitement de déficiences associées au vieillissement, et compositions utilisées pour cette modulation |
US20160208011A1 (en) | 2010-01-28 | 2016-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
US9161968B2 (en) | 2011-04-08 | 2015-10-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists |
JP6667438B2 (ja) | 2013-12-09 | 2020-03-18 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 老化に関連する状態を処置する方法及び組成物 |
US10905779B2 (en) | 2013-12-09 | 2021-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for screening human blood products comprising plasma using immunocompromised rodent models |
JP6921006B2 (ja) | 2015-06-15 | 2021-08-18 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 老化関連症状を治療するための方法および組成物 |
US11007230B1 (en) * | 2015-08-28 | 2021-05-18 | University Of South Florida | Plasma derived from human umbilical cord blood for the treatment of neurodegenerative disorders |
US11628190B2 (en) * | 2015-08-28 | 2023-04-18 | University Of South Florida | Plasma derived from human umbilical cord blood for the treatment of neurodegenerative disorders |
ES2900302T3 (es) | 2016-04-28 | 2022-03-16 | Alkahest Inc | Fracciones de plasma como terapia para el crecimiento y la progresión del tumor |
US10495554B2 (en) * | 2016-05-25 | 2019-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Method and system for imaging and analysis of a biological specimen |
WO2018027116A1 (fr) * | 2016-08-05 | 2018-02-08 | Jay Yadav | Stockage de plasma dans une banque pour atténuer le vieillissement. |
CN109963582B (zh) * | 2016-08-18 | 2022-12-27 | 万能溶剂有限公司 | 作为衰老相关认知障碍的治疗的血浆级分 |
US10525107B2 (en) * | 2016-08-18 | 2020-01-07 | Alkahest, Inc. | Blood plasma fractions as a treatment for aging-associated cognitive disorders |
WO2018071869A1 (fr) * | 2016-10-14 | 2018-04-19 | The Regents Of The University Of California | Échange de sang hétérochronique en tant que modalité pour influencer la myogenèse, la neurogenèse et la régénération du foie |
CN106581062B (zh) * | 2016-12-29 | 2020-09-18 | 江苏豪思睦可生物科技有限公司 | 一种用于改善记忆力的混合物及其制备方法和应用 |
CN106581063B (zh) * | 2016-12-29 | 2018-11-06 | 北京豪思生物科技有限公司 | 一种用于增强记忆力的血浆分离物及其制备方法和应用 |
MA48480A (fr) * | 2017-04-26 | 2020-03-04 | Alkahest Inc | Schéma posologique pour le traitement de déficiences cognitives et motrices avec du plasma sanguin et des produits de plasma sanguin |
US11040068B2 (en) | 2017-04-26 | 2021-06-22 | Alkahest, Inc. | Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products |
ES2690178A1 (es) * | 2017-05-18 | 2018-11-19 | Apc Europe Slu | Plasma de animal o fracciones del mismo para su utilización en el tratamiento de trastornos de deterioro cognitivo en seres humanos y animales de compañia |
EP3765010A2 (fr) * | 2018-03-13 | 2021-01-20 | Nuchido Limited | Méthode de traitement |
AU2019271122A1 (en) * | 2018-05-15 | 2020-11-12 | Alkahest, Inc. | Treatment of aging-associated disease with modulators of leukotriene A4 hydrolase |
CA3115308A1 (fr) | 2018-10-26 | 2020-04-30 | Alkahest, Inc. | Utilisation de plasma et de fractions de plasma pour attenuer la douleur, ameliorer la cicatrisation des plaies et la recuperation post-operatoire |
US20220362293A1 (en) * | 2019-09-25 | 2022-11-17 | Cytegen Corp. | Treatment of Mitochondrial Deficits and Age-Related Diseases Using Blood Products |
WO2021091855A1 (fr) | 2019-11-04 | 2021-05-14 | Alkahest, Inc. | Fraction de plasma sanguin à utiliser dans la régénération musculaire |
US11484551B2 (en) | 2019-11-20 | 2022-11-01 | Alkahest, Inc. | Method of treating liver failure with plasma fraction IV-4 |
CA3156906A1 (fr) | 2019-11-20 | 2021-05-27 | Alkahest, Inc. | Fractions de plasma sanguin destinees a etre utilisees dans la regeneration du foie |
CN114748504A (zh) * | 2020-12-29 | 2022-07-15 | 南京优智源医药科技有限公司 | 年轻人血浆外泌体在制备治疗衰老引发的退行性疾病的药物中的应用 |
CA3179018A1 (fr) * | 2021-01-06 | 2022-07-14 | Yuvan Research, Inc. | Compositions anti-age et leurs utilisations |
CN113081079B (zh) * | 2021-03-30 | 2022-04-22 | 中国科学院生态环境研究中心 | 血桥限位器 |
TW202408548A (zh) * | 2022-07-06 | 2024-03-01 | 美商鈺凡研究公司 | 富含rna之抗老化組合物及其用途 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060198851A1 (en) * | 2004-12-15 | 2006-09-07 | Guriq Basi | Humanized Abeta antibodies for use in improving cognition |
US20100324079A1 (en) * | 2006-03-16 | 2010-12-23 | Yasumasa Ohyagi | Medicament for prophylaxis and treatment of Alzheimer disease |
WO2013142135A1 (fr) * | 2012-03-20 | 2013-09-26 | Albert Einstein College Of Medicine Of Yeshiva University | Procédé d'amélioration de l'efficacité de transfusions sanguines |
Family Cites Families (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4708713A (en) | 1984-11-16 | 1987-11-24 | Anisa Medical, Inc. | Method and system for removing immunosuppressive components from the blood of mammals |
EP0319862B1 (fr) | 1987-12-11 | 1994-01-12 | Akzo Nobel N.V. | Membrane biocompatible de cellulose pour la dialyse, à adsorption élevée de bêta-2-microglobuline |
AU634533B2 (en) | 1989-03-21 | 1993-02-25 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Matrix metalloproteinase inhibitor peptides |
US5240614A (en) | 1992-01-10 | 1993-08-31 | Baxter International Inc. | Process for removing unwanted materials from fluids and for producing biological products |
US6544761B2 (en) | 1994-12-13 | 2003-04-08 | Human Genome Sciences, Inc. | Human tissue inhibitor of metalloproteinase-4 |
GB9607287D0 (en) | 1996-04-09 | 1996-06-12 | British Biotech Pharm | Diagnosis method |
US5916202A (en) | 1996-08-30 | 1999-06-29 | Haswell; John N. | Umbilical cord blood collection |
US5904663A (en) | 1997-07-30 | 1999-05-18 | Braverman; Andrew | Method of removing beta-2 microglobulin from blood |
US6416487B1 (en) | 1997-07-30 | 2002-07-09 | Renal Tech International Llc | Method of removing beta-2 microglobulin from blood |
US20020159995A1 (en) | 1997-07-30 | 2002-10-31 | Renal Tech International | Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood, generated as a result of extracorporeal blood processing |
AUPP790898A0 (en) | 1998-12-23 | 1999-01-28 | Life Therapeutics Limited | Renal dialysis |
AUPR748501A0 (en) | 2001-09-04 | 2001-09-27 | Life Therapeutics Limited | Renal dialysis |
CA2702148C (fr) | 1999-01-06 | 2014-03-04 | Genenews Inc. | Methode de profilage de l'expression genique d'un sujet humain atteint d'une maladie infectieuse |
ATE464947T1 (de) | 1999-01-22 | 2010-05-15 | Dow Global Technologies Inc | Oberflächenverändertes divinylbenzenharz mit hämokompatibler beschichtung |
UA35656C2 (uk) | 1999-12-27 | 2001-04-16 | Олександр Миколайович Макаренко | Спосіб лікування безперервно прогредієнтних ослабоумлюючих психічних захворювань |
US7582292B2 (en) | 2000-02-26 | 2009-09-01 | Artecel, Inc. | Adipose tissue derived stromal cells for the treatment of neurological disorders |
US6946546B2 (en) | 2000-03-06 | 2005-09-20 | Cambridge Antibody Technology Limited | Human antibodies against eotaxin |
GB0015761D0 (en) | 2000-06-27 | 2000-08-16 | Univ Bristol | Polypeptide |
US6632174B1 (en) | 2000-07-06 | 2003-10-14 | Cognifit Ltd (Naiot) | Method and apparatus for testing and training cognitive ability |
US20020151064A1 (en) | 2001-02-07 | 2002-10-17 | Children's Hospital Medical Center | Regulation of CCR3 expression |
WO2003006006A1 (fr) | 2001-07-09 | 2003-01-23 | The Regents Of The University Of California | Utilisation d'inhibiteurs de metalloproteinases matricielles pour limiter les atteintes nerveuses |
AU2002313737A1 (en) | 2001-08-13 | 2003-04-01 | University Of Kentucky Research Foundation | Gene expression profile biomarkers and therapeutic targets for brain aging and age-related cognitive impairment |
US6906036B2 (en) | 2001-08-16 | 2005-06-14 | Kimberly-Clark Worldwide, Inc. | Anti-aging and wound healing compounds |
US7608406B2 (en) | 2001-08-20 | 2009-10-27 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
US20050048035A1 (en) | 2001-12-07 | 2005-03-03 | Fraser John K. | Methods of using regenerative cells in the treatment of stroke and related diseases and disorders |
EP1394549A1 (fr) | 2002-08-23 | 2004-03-03 | Bayer HealthCare AG | Biomarqueurs pour le diagnostic de la maladie d'Alzheimer |
CA2496321C (fr) | 2002-08-23 | 2013-05-21 | Bayer Healthcare Ag | Marqueurs biologiques permettant le diagnostic de la maladie d'alzheimer |
US20040127445A1 (en) | 2002-08-28 | 2004-07-01 | Chondrogene Limited | Beta-2 microglobulin (B2M) and B2M related gene products for the regulation of osteoarthritis pathogenesis and chondrocyte proliferation |
US20050244448A1 (en) | 2002-10-14 | 2005-11-03 | The Board Of Trustees Of The Leland Stanford Jr. University | Diagnosis and treatment of disorders of collagen and elastin metabolism |
US20040120937A1 (en) * | 2002-12-19 | 2004-06-24 | Therapy Patent Corporation | Blood therapy process |
CN1732023A (zh) | 2002-12-27 | 2006-02-08 | 血管技术国际股份公司 | 组合物和使用collajolie的方法 |
US7785601B2 (en) | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
GB0305133D0 (en) * | 2003-03-06 | 2003-04-09 | Sinvent As | Product |
EP1608374B9 (fr) | 2003-03-24 | 2009-04-08 | Axikin Pharmaceuticals, Inc. | Derives de 2-phenoxy- et 2-phenylsulfonamide a activite antagoniste de ccr3 pour le traitement de l'asthme et d'autres troubles inflammatoires ou immunologiques |
WO2004093802A2 (fr) | 2003-04-17 | 2004-11-04 | The Board Of Trustees Of The Leland Stanford Junior University | Prevention des troubles de neurogenese deficitaire a l'aide d'agents anti-inflammatoires |
WO2004111608A2 (fr) | 2003-06-09 | 2004-12-23 | Mcintyre John A | Procede permettant de modifier la specificite de liaison des proteines plasmiques au moyen de reactions d'oxydation-reduction |
US20060094064A1 (en) | 2003-11-19 | 2006-05-04 | Sandip Ray | Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids |
EP1692520A2 (fr) | 2003-11-19 | 2006-08-23 | Satoris, Inc. | Methodes et compositions pour le diagnostic, la stratification et la surveillance de la maladie d'alzheimer |
US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
WO2005106492A2 (fr) | 2004-04-30 | 2005-11-10 | Bayer Healthcare Ag | Diagnostic et traitement therapeutique des maladies associees au recepteur 3 de la chimiokine c-c (ccr3) |
JP4908216B2 (ja) | 2004-07-23 | 2012-04-04 | 株式会社カネカ | 水不溶性微粒子を除去した吸着材を充填した直接血液灌流用吸着器、および水不溶性微粒子を除去した直接血液灌流用吸着材の取得方法 |
US20090209615A1 (en) | 2004-09-27 | 2009-08-20 | Stuart Lipton | Inhibitors of matrix metalloproteinases to treat neurological disorders |
AU2006227368A1 (en) | 2005-03-18 | 2006-09-28 | Oregon Health & Science University | Recombinant MHC molecules useful for manipulation of antigen-specific T cells |
EP1929297B1 (fr) | 2005-09-29 | 2012-11-21 | Caprion Proteomics USA, LLC | Marqueurs biologiques de la sclerose en plaques et methodes d'utilisation de ceux-ci |
US20090181008A1 (en) | 2005-11-10 | 2009-07-16 | Satoris, Inc. | Methods of treating alzheimer's disease |
US20080125354A1 (en) | 2005-11-21 | 2008-05-29 | Florida Atlantic University | Selective inhibition of matrix metalloproteinases |
US7908090B2 (en) | 2005-11-30 | 2011-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Signatures for human aging |
US10344095B2 (en) | 2006-02-16 | 2019-07-09 | University Of Kentucky Research Foundation | CCR3 inhibition for ocular angiogenesis and macular degeneration |
EP1986657A4 (fr) | 2006-02-16 | 2011-07-20 | Discogen Llc | Procédé de traitement d'un sujet souffrant de discopathie dégénérative par un inhibiteur de la métalloprotéase de la matrice |
US20080026485A1 (en) | 2006-04-18 | 2008-01-31 | Wolfgang Hueber | Antibody profiling for determination of patient responsiveness |
CA2659082A1 (fr) | 2006-06-07 | 2007-12-21 | Tethys Bioscience, Inc. | Marqueurs associes a des evenements arterio-vasculaires et procedes d'utilisation de ces marqueurs |
US7851172B2 (en) | 2006-07-25 | 2010-12-14 | University Of Kentucky Research Foundation | Biomarkers of mild cognitive impairment and alzheimer's disease |
US7592009B2 (en) | 2006-10-10 | 2009-09-22 | Ecole Polytechnique Federale De Lausanne (Epfl) | Polypeptide ligands for targeting cartilage and methods of use thereof |
US8211310B2 (en) | 2006-11-20 | 2012-07-03 | Cytosorbents, Inc. | Size-selective polymer system |
WO2009008928A2 (fr) | 2007-04-13 | 2009-01-15 | Stemnion, Inc. | Procédés pour le traitement d'une lésion et d'une maladie du système nerveux |
GB0710522D0 (en) | 2007-06-01 | 2007-07-11 | Royal Veterinary College The | Drug delivery system comprising matrix metalloproteinase inhibitors |
WO2009023814A2 (fr) * | 2007-08-15 | 2009-02-19 | University Of South Florida | Traitement de hucbc pour des maladies associées à la substance amyloïde |
WO2009051660A2 (fr) | 2007-10-12 | 2009-04-23 | The Board Of Trustees Of The Leland Stanford Junior University | Composés permettant l'activation de la signalisation tgf-bêta |
US20100015235A1 (en) | 2008-04-28 | 2010-01-21 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
US20090227018A1 (en) | 2007-10-25 | 2009-09-10 | Revalesio Corporation | Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction |
US20100310609A1 (en) | 2007-10-25 | 2010-12-09 | Revalesio Corporation | Compositions and methods for treatment of neurodegenerative diseases |
EP2216060B2 (fr) | 2007-12-06 | 2021-03-17 | Asahi Kasei Medical Co., Ltd. | Membrane poreuse à fibres creuses pour le traitement de sang |
US20110142848A1 (en) | 2008-08-07 | 2011-06-16 | Chung Leland W K | Anti-beta-2-microglobulin agents and the use thereof |
US8802627B2 (en) | 2008-10-09 | 2014-08-12 | Oriental Yeast Co., Ltd. | Fusion protein composed of matrix metalloproteinase-2 inhibitor peptide derived from amyloid-B precursor protein and tissue inhibitor of metalloproteinase-2 |
US20100124756A1 (en) | 2008-10-10 | 2010-05-20 | Sandip Ray | Collection of biomarkers for diagnosis and monitoring of alzheimer's disease in body fluids |
US20110117100A1 (en) | 2008-11-03 | 2011-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for diagnosis, stratification and treatment of amyloidogenic diseases |
WO2010138591A1 (fr) | 2009-05-26 | 2010-12-02 | University Of Kentucky Research Foundation | Ccr3 et ses ligands sont des cibles thérapeutiques et de diagnostics pour une dégénérescence maculaire néo-vasculaire liée à l'âge |
US20160208011A1 (en) | 2010-01-28 | 2016-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
US20130040844A1 (en) | 2010-01-28 | 2013-02-14 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarkers of aging for detection and treatment of disorders |
WO2017120461A1 (fr) | 2016-01-08 | 2017-07-13 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation du ccr3 pour le traitement de déficiences associées au vieillissement, et compositions utilisées pour cette modulation |
WO2016187217A2 (fr) | 2015-05-18 | 2016-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Méthodes et compositions permettant de traiter des troubles associés au vieillissement |
US20110202284A1 (en) | 2010-02-10 | 2011-08-18 | Mcreynolds Cristopher | Novel groups of biomarkers for diagnosing alzheimer's disease |
RU2428997C1 (ru) | 2010-03-01 | 2011-09-20 | Федеральное государственное образовательное учреждение высшего профессионального образования Волгоградская государственная сельскохозяйственная академия | Способ получения лечебных препаратов из пуповины плода |
AR080698A1 (es) | 2010-04-01 | 2012-05-02 | Imclone Llc | Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e |
NZ626610A (en) | 2010-05-04 | 2015-11-27 | Five Prime Therapeutics Inc | Antibodies that bind csf1r |
US9161968B2 (en) | 2011-04-08 | 2015-10-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists |
US9782457B2 (en) | 2011-10-07 | 2017-10-10 | Tissue Repair Company | Flowable formulations for tissue repair and regeneration |
RU2470677C1 (ru) | 2011-10-19 | 2012-12-27 | Надежда Михайловна Цулая | Способ стимуляции репаративных и трофических процессов в коже |
US20140294724A1 (en) | 2011-10-24 | 2014-10-02 | Intellect Neurosciences, Inc. | Compositions and methods for treatment of proteinopathies |
WO2013122950A1 (fr) | 2012-02-13 | 2013-08-22 | Wuyi Kong | Nprcp, pfdnc et leurs utilisations |
US20130302322A1 (en) | 2012-05-11 | 2013-11-14 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
RU2635560C2 (ru) | 2012-10-29 | 2017-11-14 | Чайна Петролеум Энд Кемикал Корпорейшн | Способ адсорбционной десульфуризации углеводородов и реакторное устройство для его осуществления |
CA2930874A1 (fr) | 2013-11-26 | 2015-06-04 | University Of North Texas Health Science Center At Fort Worth | Approche medicale personnalisee pour le traitement d'une perte cognitive |
US10905779B2 (en) | 2013-12-09 | 2021-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for screening human blood products comprising plasma using immunocompromised rodent models |
JP6667438B2 (ja) | 2013-12-09 | 2020-03-18 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 老化に関連する状態を処置する方法及び組成物 |
US20150359847A1 (en) | 2014-04-16 | 2015-12-17 | Blood Systems Research Institute | Method and composition for conferring neuroprotection |
JP6921006B2 (ja) | 2015-06-15 | 2021-08-18 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 老化関連症状を治療するための方法および組成物 |
-
2014
- 2014-12-05 JP JP2016538066A patent/JP6667438B2/ja not_active Expired - Fee Related
- 2014-12-05 KR KR1020207025969A patent/KR102351604B1/ko active IP Right Grant
- 2014-12-05 CN CN201480075207.3A patent/CN106163530A/zh active Pending
- 2014-12-05 EP EP14868769.2A patent/EP3079708A4/fr not_active Withdrawn
- 2014-12-05 AU AU2014364182A patent/AU2014364182B2/en not_active Ceased
- 2014-12-05 NZ NZ720949A patent/NZ720949A/en not_active IP Right Cessation
- 2014-12-05 BR BR112016012968A patent/BR112016012968A2/pt not_active Application Discontinuation
- 2014-12-05 MX MX2016007492A patent/MX2016007492A/es unknown
- 2014-12-05 CA CA2933440A patent/CA2933440A1/fr not_active Abandoned
- 2014-12-05 US US14/562,401 patent/US10688130B2/en not_active Expired - Fee Related
- 2014-12-05 KR KR1020167017990A patent/KR102155857B1/ko active IP Right Grant
- 2014-12-05 WO PCT/US2014/068897 patent/WO2015088915A1/fr active Application Filing
- 2014-12-05 EA EA201690969A patent/EA035336B1/ru unknown
-
2016
- 2016-06-05 IL IL24602316A patent/IL246023B/en active IP Right Grant
-
2019
- 2019-07-11 JP JP2019129590A patent/JP6931678B2/ja active Active
-
2020
- 2020-05-21 US US16/880,384 patent/US20200352994A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060198851A1 (en) * | 2004-12-15 | 2006-09-07 | Guriq Basi | Humanized Abeta antibodies for use in improving cognition |
US20100324079A1 (en) * | 2006-03-16 | 2010-12-23 | Yasumasa Ohyagi | Medicament for prophylaxis and treatment of Alzheimer disease |
WO2013142135A1 (fr) * | 2012-03-20 | 2013-09-26 | Albert Einstein College Of Medicine Of Yeshiva University | Procédé d'amélioration de l'efficacité de transfusions sanguines |
Non-Patent Citations (2)
Title |
---|
THOMSON et al., "Young blood for a keener mind" NewScientist, 2012, Vol. 216, Issue. 2887, page 10. See the whole document * |
VILLEDA et al., "Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice" Nature Medicine, June 2014, Vol. 20, No. 6, pp. 659-663 * |
Also Published As
Publication number | Publication date |
---|---|
EP3079708A4 (fr) | 2017-08-30 |
EA201690969A1 (ru) | 2016-09-30 |
IL246023B (en) | 2019-11-28 |
KR20160086965A (ko) | 2016-07-20 |
KR102351604B1 (ko) | 2022-01-18 |
US20200352994A1 (en) | 2020-11-12 |
NZ720949A (en) | 2019-03-29 |
US20150157664A1 (en) | 2015-06-11 |
JP6931678B2 (ja) | 2021-09-08 |
CN106163530A (zh) | 2016-11-23 |
JP6667438B2 (ja) | 2020-03-18 |
IL246023A0 (en) | 2016-07-31 |
AU2014364182A1 (en) | 2016-06-30 |
JP2016539992A (ja) | 2016-12-22 |
MX2016007492A (es) | 2017-03-06 |
AU2014364182B2 (en) | 2019-03-07 |
JP2019194249A (ja) | 2019-11-07 |
EP3079708A1 (fr) | 2016-10-19 |
KR20200108372A (ko) | 2020-09-17 |
BR112016012968A2 (pt) | 2017-08-08 |
KR102155857B1 (ko) | 2020-09-15 |
WO2015088915A1 (fr) | 2015-06-18 |
US10688130B2 (en) | 2020-06-23 |
CA2933440A1 (fr) | 2015-06-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6931678B2 (ja) | 老化に関連する状態を処置する方法及び組成物 | |
US20210236656A1 (en) | Methods for screening human blood products comprising plasma using immunocompromised rodent models | |
JP7447069B2 (ja) | 加齢性認知障害の処置としての血漿画分 | |
US10525107B2 (en) | Blood plasma fractions as a treatment for aging-associated cognitive disorders | |
Vinsant et al. | Characterization of early pathogenesis in the SOD1 G93A mouse model of ALS: part I, background and methods | |
Shehadah et al. | Human placenta-derived adherent cell treatment of experimental stroke promotes functional recovery after stroke in young adult and older rats | |
Akassoglou et al. | In vivo imaging of CNS injury and disease | |
Huang et al. | TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels | |
Liao et al. | Different mechanisms for loss and recovery of binocularity in the visual cortex | |
WO2009088314A1 (fr) | Procédé de production d'un complexe biologiquement actif présentant une activité neurorégénérative et neuroprotectrice | |
Gandhi et al. | Behavioral regulation by perineuronal nets in the prefrontal cortex of the CNTNAP2 mouse model of autism spectrum disorder | |
JP2020530033A (ja) | 神経学的疾患を治療するための方法および組成物 | |
Rendevski et al. | Advanced 3D modeling for prediction and quantification of the perihematomal brain edema formation after ICH: implications of biochemical, radiological and clinical variables | |
Drost | Characterization and manipulation of myeloid cells in the healthy and diseased Central Nervous System | |
Fisher | Clozapine-induced paroxysmal discharges |