EA034795B1 - Способ определения изменений фекальной микробиоты индивида после приема композиции, содержащей микроорганизмы - Google Patents
Способ определения изменений фекальной микробиоты индивида после приема композиции, содержащей микроорганизмы Download PDFInfo
- Publication number
- EA034795B1 EA034795B1 EA201690465A EA201690465A EA034795B1 EA 034795 B1 EA034795 B1 EA 034795B1 EA 201690465 A EA201690465 A EA 201690465A EA 201690465 A EA201690465 A EA 201690465A EA 034795 B1 EA034795 B1 EA 034795B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- lactobacillus
- microorganisms
- composition
- placebo
- individual
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/10—Enterobacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001473A ITMI20131473A1 (it) | 2013-09-06 | 2013-09-06 | Metodo per valutare gli effetti di una composizione comprendente microrganismi sul microbiota intestinale |
| PCT/IB2014/064284 WO2015033304A1 (en) | 2013-09-06 | 2014-09-05 | Method for evaluating the effects of a composition comprising microorganisms on intestinal microbiota |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201690465A1 EA201690465A1 (ru) | 2016-08-31 |
| EA034795B1 true EA034795B1 (ru) | 2020-03-23 |
Family
ID=49354801
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201690465A EA034795B1 (ru) | 2013-09-06 | 2014-09-05 | Способ определения изменений фекальной микробиоты индивида после приема композиции, содержащей микроорганизмы |
| EA202090097A EA202090097A1 (ru) | 2013-09-06 | 2014-09-05 | Способ оценки эффектов композиции, содержащей микроорганизмы, на кишечную микробиоту |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202090097A EA202090097A1 (ru) | 2013-09-06 | 2014-09-05 | Способ оценки эффектов композиции, содержащей микроорганизмы, на кишечную микробиоту |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20160348155A1 (enExample) |
| EP (1) | EP3047032A1 (enExample) |
| JP (1) | JP6701078B2 (enExample) |
| CN (1) | CN105518150A (enExample) |
| BR (1) | BR112016005064A2 (enExample) |
| CA (1) | CA2923390A1 (enExample) |
| EA (2) | EA034795B1 (enExample) |
| HK (1) | HK1223982A1 (enExample) |
| IL (1) | IL244391B (enExample) |
| IT (1) | ITMI20131473A1 (enExample) |
| MX (2) | MX2016002766A (enExample) |
| SG (1) | SG11201601664VA (enExample) |
| WO (1) | WO2015033304A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4575491A1 (en) | 2023-12-22 | 2025-06-25 | Vilnius University | Method for detecting volatile organic compounds in faecal matter odour |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20131467A1 (it) | 2013-09-06 | 2015-03-07 | Sofar Spa | Uso di una composizione comprendente microrganismi per aumentare la produzione intestinale di acido butirrico, di acido folico o di niacina e/o per diminuire la produzione intestinale di acido succinico |
| MA39710A (fr) | 2014-04-23 | 2015-10-29 | Sofar Spa | Composition topique destinée à être utilisée dans le traitement d'une maladie inflammatoire de l'intestin |
| CN108350508B (zh) * | 2015-10-29 | 2021-09-17 | 株式会社益力多本社 | 雌马酚产生能力的测定方法 |
| IT201600083376A1 (it) | 2016-08-08 | 2018-02-08 | Sofar Spa | Uso di probiotici per aumentare l’assorbimento proteico |
| ITUA20164188A1 (it) * | 2016-06-08 | 2017-12-08 | Sofar Spa | Nuovo uso medico di probiotici |
| CN106318890A (zh) * | 2016-10-21 | 2017-01-11 | 山东省农业科学院畜牧兽医研究所 | 一株分离自spf鸡嗉囊的产植酸酶卷曲乳杆菌菌株及其应用 |
| IT201600122724A1 (it) * | 2016-12-02 | 2018-06-02 | Sofar Spa | Exopolysaccharides and uses thereof |
| IT201600127498A1 (it) | 2016-12-16 | 2018-06-16 | Sofar Spa | Probiotici per uso nella diverticolosi e malattia diverticolare |
| IT201700101704A1 (it) * | 2017-09-12 | 2019-03-12 | Sofar Spa | Nuovo uso per trattamento delle infezioni da clostridium difficile |
| US20200347440A1 (en) * | 2018-01-17 | 2020-11-05 | Consorcio Centro de Investigación Biomédica en Red, M.P. | Targeted interventions directed at reducing the levels of circulating succinate in a subject, and kits and method for determining effectiveness of said interventions |
| WO2019155044A1 (en) | 2018-02-09 | 2019-08-15 | N.V. Nutricia | Fermented formula with non-digestible oligosaccharides |
| CN112204139A (zh) * | 2018-04-02 | 2021-01-08 | 太阳基因组学公司 | 用于从样品中的一种或多种类型的微生物的不同群体中提取核酸分子的通用方法 |
| CN110029155A (zh) * | 2019-05-27 | 2019-07-19 | 天益健康科学研究院（镇江）有限公司 | 一种基于荧光定量pcr组合式肠道细菌检测方法 |
| US11751597B2 (en) | 2019-11-05 | 2023-09-12 | Alfasigma S.P.A. | Compositions comprising bacterial strains for use in increasing the bioavailability of amino acids derived from proteins, and related food product methods and systems |
| CN112980712A (zh) * | 2019-12-14 | 2021-06-18 | 山东大学 | 一种调节高原人群情绪及肠道菌群稳定的微生物组合物及其应用 |
| CN116287163A (zh) * | 2023-02-17 | 2023-06-23 | 浙江大学 | 一种评估肠道菌群对菊粉的动态响应方法 |
Citations (9)
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| WO2004022727A1 (en) * | 2002-09-06 | 2004-03-18 | Vri Biomedical Ltd | Probiotic bacterium: lactobacillus fermentum |
| US20040170617A1 (en) * | 2000-06-05 | 2004-09-02 | Finegold Sydney M. | Method of treating diseases associated with abnormal gastrointestinal flora |
| WO2005001109A2 (en) * | 2003-05-06 | 2005-01-06 | Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health | Methods and compositions to detect microbes in fecal samples |
| WO2005083122A2 (en) * | 2004-02-27 | 2005-09-09 | Stichting Laboratorium Voor Infectieziekten | Method for detecting a microorganism in a fecal specimen |
| WO2006050479A2 (en) * | 2004-11-01 | 2006-05-11 | George Mason University | Compositions and methods for diagnosing colon disorders |
| CN1840206A (zh) * | 2006-01-19 | 2006-10-04 | 上海交通大学 | 人源菌群仔猪模型的构建及仔猪肠道中菌群分子检测方法 |
| WO2007071815A1 (en) * | 2005-12-22 | 2007-06-28 | Cyflo Oy | Method for monitoring and promoting the nutrition and well-being of an animal and/or a human being as well as the productivity of animals |
| US20090061446A1 (en) * | 2006-02-21 | 2009-03-05 | National University Corporation University Of Toyama | Method for quickly identifying pathogenic bacteria responsible for infection |
| US20100112564A1 (en) * | 2008-02-21 | 2010-05-06 | Shanghai Jiao Tong University | Methods for detecting therapeutic effects of anti-cancer drugs |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010161944A (ja) * | 2009-01-13 | 2010-07-29 | Syngen Biotech Co Ltd | 新型カゼイ菌の亜種（ｓｇ９６）及びこれを含有する菌抑制組成物及びその用途 |
-
2013
- 2013-09-06 IT IT001473A patent/ITMI20131473A1/it unknown
-
2014
- 2014-09-05 CN CN201480049288.XA patent/CN105518150A/zh active Pending
- 2014-09-05 EA EA201690465A patent/EA034795B1/ru unknown
- 2014-09-05 EP EP14790322.3A patent/EP3047032A1/en not_active Withdrawn
- 2014-09-05 MX MX2016002766A patent/MX2016002766A/es unknown
- 2014-09-05 HK HK16112010.3A patent/HK1223982A1/zh unknown
- 2014-09-05 JP JP2016539666A patent/JP6701078B2/ja not_active Expired - Fee Related
- 2014-09-05 SG SG11201601664VA patent/SG11201601664VA/en unknown
- 2014-09-05 CA CA2923390A patent/CA2923390A1/en active Pending
- 2014-09-05 BR BR112016005064A patent/BR112016005064A2/pt not_active Application Discontinuation
- 2014-09-05 WO PCT/IB2014/064284 patent/WO2015033304A1/en not_active Ceased
- 2014-09-05 EA EA202090097A patent/EA202090097A1/ru unknown
- 2014-09-05 US US14/916,959 patent/US20160348155A1/en not_active Abandoned
-
2016
- 2016-03-02 MX MX2022013625A patent/MX2022013625A/es unknown
- 2016-03-02 IL IL244391A patent/IL244391B/en active IP Right Grant
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040170617A1 (en) * | 2000-06-05 | 2004-09-02 | Finegold Sydney M. | Method of treating diseases associated with abnormal gastrointestinal flora |
| WO2004022727A1 (en) * | 2002-09-06 | 2004-03-18 | Vri Biomedical Ltd | Probiotic bacterium: lactobacillus fermentum |
| WO2005001109A2 (en) * | 2003-05-06 | 2005-01-06 | Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health | Methods and compositions to detect microbes in fecal samples |
| WO2005083122A2 (en) * | 2004-02-27 | 2005-09-09 | Stichting Laboratorium Voor Infectieziekten | Method for detecting a microorganism in a fecal specimen |
| WO2006050479A2 (en) * | 2004-11-01 | 2006-05-11 | George Mason University | Compositions and methods for diagnosing colon disorders |
| WO2007071815A1 (en) * | 2005-12-22 | 2007-06-28 | Cyflo Oy | Method for monitoring and promoting the nutrition and well-being of an animal and/or a human being as well as the productivity of animals |
| CN1840206A (zh) * | 2006-01-19 | 2006-10-04 | 上海交通大学 | 人源菌群仔猪模型的构建及仔猪肠道中菌群分子检测方法 |
| US20090061446A1 (en) * | 2006-02-21 | 2009-03-05 | National University Corporation University Of Toyama | Method for quickly identifying pathogenic bacteria responsible for infection |
| US20100112564A1 (en) * | 2008-02-21 | 2010-05-06 | Shanghai Jiao Tong University | Methods for detecting therapeutic effects of anti-cancer drugs |
Non-Patent Citations (3)
| Title |
|---|
| "Example Cross-Over Study Design (A Phase II, Randomized, Double-Blind Crossover Study of Hypertena and Placebo in Participants with High Blood Pressure) Methods Study Design", October 2012 (2012-10), XP055119522, Retrieved from the Internet: URL: http: //prsinfo.clinicaltrials.gov/trainTrainer/Crossover-Design-Fiction-Manuscri pt.pdf [retrieved on 2014-05-22] the whole document * |
| F. SAVINO, L. CORDISCO, V. TARASCO, E. PALUMERI, R. CALABRESE, R. OGGERO, S. ROOS, D. MATTEUZZI: "Lactobacillus reuteri DSM 17938 in Infantile Colic: A Randomized, Double-Blind, Placebo-Controlled Trial", PEDIATRICS, AMERICAN ACADEMY OF PEDIATRICS, vol. 126, no. 3, 1 September 2010 (2010-09-01), pages e526 - e533, XP055119050, ISSN: 00314005, DOI: 10.1542/peds.2010-0433 * |
| PLANT, L. ET AL.: "Association of lactobacillus spp. with Peyer's Patches in Mice", CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY., AMERICAN SOCIETY FOR MICROBIOLOGY., US, vol. 8, no. 2, 1 January 2001 (2001-01-01), US, pages 320 - 324, XP002990497, ISSN: 1071-412X, DOI: 10.1128/CDLI.8.2.320-324.2001 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4575491A1 (en) | 2023-12-22 | 2025-06-25 | Vilnius University | Method for detecting volatile organic compounds in faecal matter odour |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105518150A (zh) | 2016-04-20 |
| ITMI20131473A1 (it) | 2015-03-07 |
| BR112016005064A2 (pt) | 2017-11-21 |
| HK1223982A1 (zh) | 2017-08-11 |
| MX2022013625A (es) | 2022-11-16 |
| MX2016002766A (es) | 2016-08-03 |
| WO2015033304A1 (en) | 2015-03-12 |
| JP2016528926A (ja) | 2016-09-23 |
| EA202090097A1 (ru) | 2020-04-07 |
| IL244391A0 (en) | 2016-04-21 |
| US20160348155A1 (en) | 2016-12-01 |
| JP6701078B2 (ja) | 2020-05-27 |
| CA2923390A1 (en) | 2015-03-12 |
| EA201690465A1 (ru) | 2016-08-31 |
| IL244391B (en) | 2021-02-28 |
| SG11201601664VA (en) | 2016-04-28 |
| EP3047032A1 (en) | 2016-07-27 |
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