EA034644B1 - Применение cart19 для истощения нормальных b-клеток для индукции толерантности - Google Patents

Применение cart19 для истощения нормальных b-клеток для индукции толерантности Download PDF

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Publication number
EA034644B1
EA034644B1 EA201590209A EA201590209A EA034644B1 EA 034644 B1 EA034644 B1 EA 034644B1 EA 201590209 A EA201590209 A EA 201590209A EA 201590209 A EA201590209 A EA 201590209A EA 034644 B1 EA034644 B1 EA 034644B1
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Eurasian Patent Office
Prior art keywords
cells
cell
car
cart19
genetically modified
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EA201590209A
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English (en)
Russian (ru)
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EA201590209A1 (ru
Inventor
Брюс Л. Левин
Майкл Д. Кейлос
Карл Х. Джун
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Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания
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Publication of EA201590209A1 publication Critical patent/EA201590209A1/ru
Publication of EA034644B1 publication Critical patent/EA034644B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201590209A 2012-07-13 2013-07-12 Применение cart19 для истощения нормальных b-клеток для индукции толерантности EA034644B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261671508P 2012-07-13 2012-07-13
PCT/US2013/050293 WO2014012001A2 (en) 2012-07-13 2013-07-12 Use of cart19 to deplete normal b cells to induce tolerance

Publications (2)

Publication Number Publication Date
EA201590209A1 EA201590209A1 (ru) 2015-08-31
EA034644B1 true EA034644B1 (ru) 2020-03-02

Family

ID=49916701

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201590209A EA034644B1 (ru) 2012-07-13 2013-07-12 Применение cart19 для истощения нормальных b-клеток для индукции толерантности
EA201992742A EA201992742A3 (ru) 2012-07-13 2013-07-12 Применение cart19 для истощения нормальных b-клеток для индукции толерантности

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201992742A EA201992742A3 (ru) 2012-07-13 2013-07-12 Применение cart19 для истощения нормальных b-клеток для индукции толерантности

Country Status (13)

Country Link
US (3) US20150290244A1 (Direct)
EP (1) EP2872184B1 (Direct)
JP (5) JP2015523386A (Direct)
KR (1) KR102216083B1 (Direct)
CN (2) CN120393001A (Direct)
AU (3) AU2013289984B2 (Direct)
BR (1) BR112015000657B1 (Direct)
CA (1) CA2876734A1 (Direct)
EA (2) EA034644B1 (Direct)
ES (1) ES2835232T3 (Direct)
IN (1) IN2015DN00139A (Direct)
MX (2) MX382772B (Direct)
WO (1) WO2014012001A2 (Direct)

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Also Published As

Publication number Publication date
ES2835232T3 (es) 2021-06-22
US20150290244A1 (en) 2015-10-15
AU2013289984B2 (en) 2018-03-08
JP2015523386A (ja) 2015-08-13
AU2018203756B2 (en) 2019-10-24
CA2876734A1 (en) 2014-01-16
BR112015000657A8 (pt) 2018-01-16
BR112015000657B1 (pt) 2023-12-05
WO2014012001A2 (en) 2014-01-16
JP2025129358A (ja) 2025-09-04
AU2018203756A1 (en) 2018-06-21
WO2014012001A3 (en) 2015-04-23
US20180271907A1 (en) 2018-09-27
BR112015000657A2 (pt) 2017-06-27
EA201992742A2 (ru) 2020-09-30
EP2872184A4 (en) 2016-03-30
AU2020200315A1 (en) 2020-02-06
MX2015000433A (es) 2016-04-28
MX2018009820A (es) 2022-08-24
KR102216083B1 (ko) 2021-02-17
EA201590209A1 (ru) 2015-08-31
EP2872184B1 (en) 2020-09-16
CN104884095A (zh) 2015-09-02
AU2020200315B2 (en) 2021-11-04
EA201992742A3 (ru) 2020-12-30
US20240261328A1 (en) 2024-08-08
MX382772B (es) 2025-03-11
CN120393001A (zh) 2025-08-01
IN2015DN00139A (Direct) 2015-06-12
JP2022173331A (ja) 2022-11-18
AU2013289984A1 (en) 2015-01-22
JP2018135363A (ja) 2018-08-30
KR20150030750A (ko) 2015-03-20
EP2872184A2 (en) 2015-05-20
JP2020158541A (ja) 2020-10-01

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