EA030721B1 - Способы определения состояния туберкулезной инфекции у индивидуума - Google Patents
Способы определения состояния туберкулезной инфекции у индивидуума Download PDFInfo
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- EA030721B1 EA030721B1 EA201590220A EA201590220A EA030721B1 EA 030721 B1 EA030721 B1 EA 030721B1 EA 201590220 A EA201590220 A EA 201590220A EA 201590220 A EA201590220 A EA 201590220A EA 030721 B1 EA030721 B1 EA 030721B1
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- Eurasian Patent Office
- Prior art keywords
- individual
- mononuclear cells
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- aladh
- determining
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Cited By (1)
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| RU2726789C1 (ru) * | 2020-01-17 | 2020-07-15 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ФПИ" Минздрава России) | Способ иммунологического определения активности туберкулезной инфекции у детей и подростков с латентной инфекцией |
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| EP3171170A1 (en) * | 2015-11-17 | 2017-05-24 | Lionex GmbH | Device for use in elispot |
| KR20180104038A (ko) * | 2016-01-20 | 2018-09-19 | 시아먼 유니버시티 | 활동성 결핵의 진단을 위한 방법 및 키트 |
| CN106501530A (zh) * | 2017-01-05 | 2017-03-15 | 复旦大学附属华山医院 | 一种诊断结核杆菌感染的生物标志物及其相关试剂盒 |
| CN115598353B (zh) * | 2022-10-24 | 2024-09-13 | 首都医科大学附属北京胸科医院 | 细胞因子作为标记物在制备肺外结核诊断或治疗预后产品中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070026473A1 (en) * | 2005-07-26 | 2007-02-01 | Gennaro Maria L | Antibody profiles characteristic of tuberculosis state |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6641814B1 (en) * | 1997-04-02 | 2003-11-04 | Statens Serum Institut | Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis |
| CA2279255A1 (en) | 1997-01-29 | 1998-08-20 | Flohe, Leopold | Test kit for tuberculosis diagnosis by determining alanine dehydrogenase |
| DE102007052518A1 (de) * | 2007-10-29 | 2009-04-30 | Autoimmun Diagnostika Gmbh | Verfahren zur in vitro-Diagnose und/oder in vitro- Therapieverfolgung von Infektionen |
| CN102033129A (zh) * | 2009-09-29 | 2011-04-27 | 上海英伯肯医学生物技术有限公司 | 用抗原刺激的细胞免疫反应来检测病原微生物的方法及测试笔 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070026473A1 (en) * | 2005-07-26 | 2007-02-01 | Gennaro Maria L | Antibody profiles characteristic of tuberculosis state |
Non-Patent Citations (4)
| Title |
|---|
| DAVIDOW AMY, ET AL: "Antibody profiles characteristic of Mycobacterium tuberculosis infection state", INFECTION AND IMMUNITY, vol. 73, no. 10, 1 October 2005 (2005-10-01), pages 6846 - 6851, XP002567672, ISSN: 0019-9567, DOI: 10.1128/IAI.73.10.6846-6851.2005 * |
| ELENA CHIAPPINI, CHIARA DELLA BELLA, FRANCESCA BONSIGNORI, SARA SOLLAI, AMEDEO AMEDEI, LUISA GALLI, ELENA NICCOLAI, GIANFRANCO DEL: "Potential Role of M. tuberculosis Specific IFN-γ and IL-2 ELISPOT Assays in Discriminating Children with Active or Latent Tuberculosis", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 7, no. 9, 1 January 2012 (2012-01-01), pages e46041, XP055042205, ISSN: 19326203, DOI: 10.1371/journal.pone.0046041 * |
| M.L. Gennaro ET AL.: "Antibody markers of incident tuberculosis among HIV-infected adults in the USA: a historical prospective study", INT. J. TUBERC. LUNG. DIS., 1 June 2007 (2007-06-01), pages 624-631, XP055042331, Retrieved from the Internet: URL:http://docstore.ingenta.com/cgi-bin/ds_deliver/1/u/d/ISIS/71136129.1/iuatld/ijtld/2007/00000011/00000006/art00007/BA09D3F1C3E406CC13512370265D6560A518B9CCB6.pdf?link=http://www.ingentaconnect.com/error/delivery&format=pdf, [retrieved on 2012-10-26], the whole document * |
| V. AMANATIDOU; G. SYRIDOU; M. MAVRIKOU; M. N. TSOLIA: "Latent tuberculosis infection in children: diagnostic approaches", EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, SPRINGER, BERLIN, DE, vol. 31, no. 7, 4 January 2012 (2012-01-04), Berlin, DE, pages 1285 - 1294, XP035064008, ISSN: 1435-4373, DOI: 10.1007/s10096-011-1524-3 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2726789C1 (ru) * | 2020-01-17 | 2020-07-15 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ФПИ" Минздрава России) | Способ иммунологического определения активности туберкулезной инфекции у детей и подростков с латентной инфекцией |
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| WO2014012928A1 (en) | 2014-01-23 |
| EP2687848A1 (en) | 2014-01-22 |
| AU2013292040B2 (en) | 2018-07-12 |
| CN104541169A (zh) | 2015-04-22 |
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| DK2872896T3 (en) | 2018-04-09 |
| EA201590220A1 (ru) | 2015-06-30 |
| PT2872896T (pt) | 2018-04-02 |
| CA2878497C (en) | 2021-06-08 |
| EP2872896B1 (en) | 2017-12-27 |
| ES2666073T3 (es) | 2018-04-30 |
| EP2872896A1 (en) | 2015-05-20 |
| CA2878497A1 (en) | 2014-01-23 |
| IN2015MN00140A (enExample) | 2015-10-16 |
| CN104541169B (zh) | 2017-09-15 |
| AU2013292040A1 (en) | 2015-02-05 |
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