EA028605B1 - Комбинация озельтамивира и ингибитора mek для лечения вирусных заболеваний - Google Patents
Комбинация озельтамивира и ингибитора mek для лечения вирусных заболеваний Download PDFInfo
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- EA028605B1 EA028605B1 EA201590703A EA201590703A EA028605B1 EA 028605 B1 EA028605 B1 EA 028605B1 EA 201590703 A EA201590703 A EA 201590703A EA 201590703 A EA201590703 A EA 201590703A EA 028605 B1 EA028605 B1 EA 028605B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitor
- oseltamivir
- mek
- virus
- pharmaceutically acceptable
- Prior art date
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Applications Claiming Priority (3)
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| US201261711136P | 2012-10-08 | 2012-10-08 | |
| US61/711,136 | 2012-10-08 | ||
| PCT/EP2013/070917 WO2014056894A1 (en) | 2012-10-08 | 2013-10-08 | Mek inhibitors in the treatment of virus diseases |
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| EA201590703A1 EA201590703A1 (ru) | 2015-07-30 |
| EA028605B1 true EA028605B1 (ru) | 2017-12-29 |
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| US (2) | US9566281B2 (OSRAM) |
| EP (1) | EP2903649A1 (OSRAM) |
| JP (2) | JP6294889B2 (OSRAM) |
| KR (1) | KR102174576B1 (OSRAM) |
| CN (2) | CN105101999B (OSRAM) |
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| CA (1) | CA2886138C (OSRAM) |
| EA (1) | EA028605B1 (OSRAM) |
| WO (1) | WO2014056894A1 (OSRAM) |
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| US9181329B2 (en) * | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
| US9566281B2 (en) * | 2012-10-08 | 2017-02-14 | Atriva Therapeutics Gmbh | MEK inhibitors in the treatment of virus diseases |
| CN116942832A (zh) | 2014-05-16 | 2023-10-27 | 归属疗法有限公司 | 抗流感病毒和金黄色葡萄球菌合并感染的新型抗感染策略 |
| US20190183855A1 (en) * | 2016-08-10 | 2019-06-20 | Riken | Composition for treating hepatitis b, and method for evaluating replication activity of hepatitis b virus |
| TW201818936A (zh) * | 2016-11-25 | 2018-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種吡啶酮類衍生物醫藥組成物及其製備方法 |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| US11903917B2 (en) * | 2017-10-17 | 2024-02-20 | Atriva Therapeutics Gmbh | MEK-inhibitor for the treatment of viral and bacterial infections |
| US20190298669A1 (en) * | 2018-03-29 | 2019-10-03 | Atriva Therapeutics Gmbh | Ci-1040 for the treatment of viral diseases |
| DK3860598T3 (da) * | 2018-10-03 | 2023-10-16 | Jyvaeskylaen Yliopisto | Vemurafenib og salte heraf til anvendelse til behandling af enterovirusinfektioner |
| CN109765324B (zh) * | 2018-11-27 | 2021-03-30 | 苏州科技大学 | 一种mek1蛋白潜在抑制剂的筛选方法 |
| US20220152080A1 (en) | 2019-03-19 | 2022-05-19 | Atriva Therapeutics Gmbh | Rsk inhibitors in the treatment of virus diseases |
| LU101183B1 (en) | 2019-04-16 | 2020-10-16 | Atriva Therapeutics Gmbh | Novel mek-inhibitor for the treatment of viral and bacterial infections |
| CA3149588A1 (en) | 2019-08-27 | 2021-03-04 | Oliver Planz | Combinations of mek inhibitors with cap-dependent endonuclease inhibitors |
| BR112022005896A2 (pt) * | 2019-10-08 | 2022-06-28 | Atriva Therapeutics Gmbh | Inibidores da mek para o tratamento de infecções causadas por hantavírus |
| WO2021214296A1 (en) * | 2020-04-24 | 2021-10-28 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Treatment of corona virus infections |
| CN111494620A (zh) * | 2020-05-05 | 2020-08-07 | 华中科技大学同济医学院附属协和医院 | 曲美替尼在制备疫苗中的应用 |
| CN111529532A (zh) * | 2020-05-05 | 2020-08-14 | 华中科技大学同济医学院附属协和医院 | 曲美替尼在制备治疗肺部炎症性疾病药物及促进Tfh细胞分化药物中的应用 |
| CN112137994B (zh) * | 2020-09-15 | 2022-10-14 | 中山大学 | 小分子化合物在制备抗丝状病毒药物中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009140853A1 (en) * | 2008-05-23 | 2009-11-26 | The University Of Hong Kong | Combination therapy for the treatment of influenza |
| US20100137431A1 (en) * | 2000-04-07 | 2010-06-03 | Stephan Ludwig | Use of substances that act as cascade inhibitors of the raf/mek/erk signal cascade, for producing a medicament to treat dna and rna viruses |
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| WO1992002484A1 (en) | 1990-07-30 | 1992-02-20 | Alder Research Center Limited Partnership | Protein kinase c modulators with anti-inflammatory and antiviral activity |
| US5866601A (en) | 1995-02-27 | 1999-02-02 | Gilead Sciences, Inc. | Carbocyclic compounds |
| US5763483A (en) | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
| EP1140067A1 (en) * | 1999-01-07 | 2001-10-10 | Warner-Lambert Company | Antiviral method using mek inhibitors |
| DE10138912A1 (de) | 2001-08-08 | 2003-02-27 | Medinnova Ges Med Innovationen | Verwendung von Wirksubstanzen zur Prophylaxe und/oder Therapie von Viruserkrankungen sowie Testsystem zum Auffinden solcher Wirksubstanzen |
| UA95244C2 (ru) * | 2005-06-22 | 2011-07-25 | Плексикон, Инк. | Соединения и способ модулирования активности киназ, и показания для их применения |
| US9566281B2 (en) * | 2012-10-08 | 2017-02-14 | Atriva Therapeutics Gmbh | MEK inhibitors in the treatment of virus diseases |
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- 2013-10-08 WO PCT/EP2013/070917 patent/WO2014056894A1/en not_active Ceased
- 2013-10-08 EP EP13788684.2A patent/EP2903649A1/en not_active Withdrawn
- 2013-10-08 AU AU2013328824A patent/AU2013328824B2/en not_active Ceased
- 2013-10-08 CN CN201810617076.7A patent/CN109276716B/zh active Active
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| US20100137431A1 (en) * | 2000-04-07 | 2010-06-03 | Stephan Ludwig | Use of substances that act as cascade inhibitors of the raf/mek/erk signal cascade, for producing a medicament to treat dna and rna viruses |
| WO2009140853A1 (en) * | 2008-05-23 | 2009-11-26 | The University Of Hong Kong | Combination therapy for the treatment of influenza |
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| "Vemurafenib B-raf Kinase Inhibitor Oncolytic", DRUGS OF THE FUTURE, PROUS SCIENCE, ES, vol. 36, no. 3, 1 January 2011 (2011-01-01), ES, pages 191 - 199, XP007922458, ISSN: 0377-8282, DOI: 10.1358/dof.2011.36.3.1590788 * |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN105101999A (zh) | 2015-11-25 |
| US9566281B2 (en) | 2017-02-14 |
| BR112015007616A2 (pt) | 2017-08-08 |
| BR112015007616B1 (pt) | 2022-08-09 |
| CA2886138A1 (en) | 2014-04-17 |
| CN109276716B (zh) | 2021-06-08 |
| JP2018118971A (ja) | 2018-08-02 |
| EA201590703A1 (ru) | 2015-07-30 |
| CA2886138C (en) | 2021-10-12 |
| KR102174576B1 (ko) | 2020-11-06 |
| US20170209450A1 (en) | 2017-07-27 |
| JP6294889B2 (ja) | 2018-03-14 |
| US20150224103A1 (en) | 2015-08-13 |
| KR20150097464A (ko) | 2015-08-26 |
| EP2903649A1 (en) | 2015-08-12 |
| JP2015534562A (ja) | 2015-12-03 |
| AU2013328824B2 (en) | 2018-04-05 |
| CN109276716A (zh) | 2019-01-29 |
| AU2013328824A1 (en) | 2015-04-30 |
| WO2014056894A1 (en) | 2014-04-17 |
| CN105101999B (zh) | 2018-07-17 |
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