EA027303B1 - Hydrophilic gel for wound coating - Google Patents

Abstract

The invention refers to medicine and can be used for closure and treatment of purulent wounds, burns and other skin damages. Hydrophilic gel for wound coating contains chitosan succinate, water and ethyl alcohol as an auxiliary substance in following proportions, wt.%: chitosan succinate - 3-5, ethyl alcohol - 8-16, water is balance. The technical result is hydrophilic gel for wound coating with improved properties due to increased penetrating ability and healing and decontamination and preservation of shape on wound.

Description

The invention relates to medicine and can be used to close and treat purulent wounds, burns and other skin lesions.

In the modern world, the acute problem of treating various kinds of wounds and skin lesions. A large number of wound coverings are known in the form of films, dressings made of natural or artificial polymers. But they all have flaws. It seems promising to perform wound dressing from a biocompatible, biodegradable, natural polymer, for example chitosan. The use of a wound dressing in the form of a gel makes it possible not to injure the wound surface, to envelop small irregularities, to absorb wound exudate, etc.

Known drug [RF patent 2154488, A6K 35/78, publ. 08/20/2000], which has an anti-inflammatory and analgesic effect, containing an aqueous-alcoholic extract from plant materials and a pharmaceutically acceptable carrier, chitosan gel, using poultry as plant materials.

Known tool for the treatment of infected wounds and burns [RF patent 2140264, A61K 31/00, publ. 10.27.1999] in the form of a gel containing chitosan, medical phenol, resorcinol; boric acid; dimethyl sulfoxide; potassium iodide; glacial acetic acid; glycerol; anesthetic distilled water - the rest.

A disadvantage of the known compositions is that they have a relatively low penetration into the subcutaneous layers due to the large size of chitosan granules in the gel, as well as low disinfecting ability.

Known biologically active composition [RF patent 2197971, class. A61K 31/722, A61K 33/38, A61P 17/02, Л23Ь 1/054, publ. 02/10/2003], containing a chitosan gel or chitosan suspension with a spherical shape of nanogranules of not more than 100 nm and noble metal ions in an amount of not more than 10 wt.%. The technical result is an improvement in the quality of a biologically active composition by increasing its penetrating ability and healing and disinfecting effects. The disadvantage is toxicity due to the presence of noble metal ions that can accumulate in organs.

Closest to the claimed combination of features is a hydrophilic gel for wound dressing based on a chitosan derivative containing water and excipients distributed therein [RF patent 2422133, cl. А61К 9/00, А61Ь 15/22, А61Ь 15/28, А61Р 13/02, Л61Ь 15/44, publ. 06/27/2011], while the rare-crosslinked polymer of chitosan and polyanionic hydrocolloid, which is sucralfate or polyalginic acid, is taken as a derivative of chitosan, and stabilizers, plasticizers or modifiers are used as an auxiliary substance.

The disadvantage is the difficulty of obtaining and multicomponent, flooding the gel and draining from the wound.

The objective of the invention is to improve the quality of the composition by increasing its penetrating ability, healing and disinfecting effects and maintaining its shape on the wound.

The task is achieved in that the hydrophilic gel for wound dressing based on a chitosan derivative contains water and excipients distributed therein, while chitosan succinate is taken as a chitosan derivative, and ethyl alcohol is used as an excipient in the following ratio of components, wt.% : chitosan succinate - 3-5, ethyl alcohol - 8-16, water - the rest. And the ratio of ethyl alcohol to water is 9-20%.

The use of chitosan succinate gel as a base allows for an analgesic and bactericidal effect. Chitosan succinate also has adjuvant, anti-inflammatory and regenerative properties.

Using alcohol as an auxiliary substance allows you to get a gel that does not injure the wound surface, penetrates and envelops small irregularities, providing relief from inflammation and pain.

The use of the claimed combination of components in experimentally selected optimal ratios allows to obtain a hydrophilic gel for wound dressing with improved penetrating ability, healing and disinfecting effects and maintaining its shape on the wound.

Example 1

0.3 g of chitosan succinate is dissolved in 9 g of water. 0.8 g of ethyl alcohol is added to the obtained solution of chitosan succinate and stirred at a temperature of 25 ° C for 15 minutes. The obtained hydrophilic gel contains chitosan succinate 3%, ethyl alcohol 8%, water 89%. Ethyl alcohol is taken in an amount of 9% with respect to water. The resulting gel can be used as a wound dressing.

We used chitosan succinate with a molecular weight of 200,000 manufactured by Bioprogress CJSC.

The introduction of alcohol into the chitosan-water succinate composition leads to the strengthening of the network of physical bonds in the polymer, which is reflected in an increase in the activation energy of a viscous flow (from 25 to 29 kJ / mol) and an increase in the elastic modulus by 1.5 times (from 3 to 5 Pa). At the same time, the system retains the ability to flow, as evidenced by viscosity curves (dependences of dynamic viscosity on shear stress) and rather high loss modulus (3.6 Pa).

Example 2

0.5 g of chitosan succinate is dissolved in 9 g of water. 0.8 g of ethyl alcohol is added to the obtained solution of chitosan succinate and stirred at a temperature of 25 ° C for 15 minutes. The obtained hydrophilic gel contains chitosan succinate 5%, ethyl alcohol 8%, water 87%. Ethyl alcohol is taken in an amount of 9% with respect to water. The resulting gel can be used as a wound dressing.

There is an increase in the activation energy of a viscous flow (from 25 to 31 kJ / mol) and an increase in the elastic modulus by a factor of 2 (from 10 to 20 Pa). In this case, the system retains the ability to flow, as evidenced by viscosity curves (dependences of dynamic viscosity on shear stress) and rather high loss modulus (11 Pa).

Example 3

0.5 g of chitosan succinate is dissolved in 8 g of water. 1.6 g of ethyl alcohol was added to the obtained chitosan succinate solution and stirred at 25 ° C for 15 minutes. The obtained hydrophilic gel contains chitosan succinate 5%, ethyl alcohol 16%, water 79%. Ethyl alcohol is taken in an amount of 20% with respect to water. The resulting gel can be used as a wound dressing.

There is an increase in the activation energy of a viscous flow (from 25 to 33 kJ / mol) and an increase in the elastic modulus by a factor of 2 (from 13 to 25 Pa). At the same time, the system retains the ability to flow, as evidenced by viscosity curves (dynamic viscosity versus shear stress) and fairly high loss modulus (12 Pa).

When the content of chitosan succinate in the composition is less than 3 wt.% It is impossible to obtain a gel. When the content of chitosan succinate in the composition is greater than 5 wt.%, Complete dissolution of this component is not ensured.

The optimum ratio of ethyl alcohol to water is in the range from 9 to 20% (the content in the hydrophilic gel of ethyl alcohol is 8-16 wt.%). The ethanol content in the hydrophilic gel of less than 8 wt.% Does not allow the formation of a uniform, uniform gel. When the ethyl alcohol content is more than 16 wt.%, Chitosan is planted.

The use of the claimed invention in medical practice allows the treatment of wounds and skin lesions at various stages of healing with the ability to provide the required therapeutic effects depending on the stage of healing and the objective state of the wound. The proposed wound cover has improved qualities by increasing penetration, healing and disinfecting effects and maintaining shape on the wound.

Thus, the inventive hydrophilic gel for wound dressing has significant advantages compared with known compositions of the same purpose.

Claims (2)

CLAIM 1. Hydrophilic gel for wound dressing based on a chitosan derivative containing water and auxiliary substances distributed in it, characterized in that it contains chitosan succinate as a chitosan derivative, and ethyl alcohol as the auxiliary substance in the following ratio of components, wt. %: chitosan succinate - 3-5; ethyl alcohol - 8-16; water - the rest. 2. Hydrophilic gel for wound dressing according to claim 1, characterized in that ethyl alcohol is taken in an amount of 9-20% with respect to water.