EA010056B1 - Конструкции нуклеиновых кислот - Google Patents

Конструкции нуклеиновых кислот Download PDF

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Publication number
EA010056B1
EA010056B1 EA200600746A EA200600746A EA010056B1 EA 010056 B1 EA010056 B1 EA 010056B1 EA 200600746 A EA200600746 A EA 200600746A EA 200600746 A EA200600746 A EA 200600746A EA 010056 B1 EA010056 B1 EA 010056B1
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EA
Eurasian Patent Office
Prior art keywords
sequence
nucleic acid
promoter
intron
early
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EA200600746A
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English (en)
Russian (ru)
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EA200600746A1 (ru
Inventor
Джеймс Фуллер
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Паудерджект Вэксинс, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34435038&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA010056(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Паудерджект Вэксинс, Инк. filed Critical Паудерджект Вэксинс, Инк.
Publication of EA200600746A1 publication Critical patent/EA200600746A1/ru
Publication of EA010056B1 publication Critical patent/EA010056B1/ru

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    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N2830/60Vector systems having a special element relevant for transcription from viruses

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EA200600746A 2003-10-10 2004-10-11 Конструкции нуклеиновых кислот EA010056B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50993603P 2003-10-10 2003-10-10
PCT/GB2004/004279 WO2005035771A2 (en) 2003-10-10 2004-10-11 Nucleic acid constructs

Publications (2)

Publication Number Publication Date
EA200600746A1 EA200600746A1 (ru) 2006-10-27
EA010056B1 true EA010056B1 (ru) 2008-06-30

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EA200600746A EA010056B1 (ru) 2003-10-10 2004-10-11 Конструкции нуклеиновых кислот

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US (1) US8663657B2 (https=)
EP (1) EP1685251B1 (https=)
JP (1) JP4814099B2 (https=)
KR (2) KR101225395B1 (https=)
CN (1) CN1890375B (https=)
AU (1) AU2004279991B2 (https=)
BR (1) BRPI0415204A (https=)
CA (1) CA2542288A1 (https=)
DK (1) DK1685251T3 (https=)
EA (1) EA010056B1 (https=)
ES (1) ES2457022T3 (https=)
IL (1) IL174848A (https=)
MX (1) MXPA06003978A (https=)
NO (1) NO20062080L (https=)
NZ (1) NZ546554A (https=)
PL (1) PL1685251T3 (https=)
PT (1) PT1685251E (https=)
SG (1) SG147430A1 (https=)
SI (1) SI1685251T1 (https=)
WO (1) WO2005035771A2 (https=)
ZA (1) ZA200603685B (https=)

Cited By (5)

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Publication number Priority date Publication date Assignee Title
RU2651498C2 (ru) * 2012-03-27 2018-04-19 Кьюрвак Аг Молекулы искусственной нуклеиновой кислоты
RU2658490C2 (ru) * 2012-03-27 2018-06-21 Кьюрвак Аг Искусственные молекулы нуклеиновых кислот для улучшенной экспрессии белков или пептидов
RU2660565C2 (ru) * 2012-03-27 2018-07-06 Кьюрвак Аг Молекулы искусственной нуклеиновой кислоты, содержащие 5'utr гена top
RU2717986C2 (ru) * 2013-12-30 2020-03-27 Куревак Аг Искусственные молекулы нуклеиновой кислоты
US11254951B2 (en) 2014-12-30 2022-02-22 Curevac Ag Artificial nucleic acid molecules

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HUE042177T2 (hu) * 2009-12-01 2019-06-28 Translate Bio Inc Szteroidszármazék mRNS szállítására humán genetikai betegségekben
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CN101993878B (zh) * 2010-10-14 2012-04-18 南京农业大学 一种rRNA嵌合启动子及含有该嵌合启动子的表达载体
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PL3586861T3 (pl) 2011-06-08 2022-05-23 Translate Bio, Inc. Kompozycje nanocząstek lipidowych i sposoby dostarczania mrna
WO2013120500A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen
WO2013120499A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
WO2013120498A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
EP3536787A1 (en) 2012-06-08 2019-09-11 Translate Bio, Inc. Nuclease resistant polynucleotides and uses thereof
DK2711426T3 (en) 2012-09-24 2015-07-13 Lonza Biologics Plc Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences
EP2938725B1 (en) 2012-12-31 2017-08-23 Boehringer Ingelheim International GmbH Heterologous intron within an immunoglobulin domain
EP2938726B1 (en) 2012-12-31 2017-09-27 Boehringer Ingelheim International GmbH Heterologous intron within a signal peptide
WO2014102104A1 (en) * 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Artificial introns
WO2014102101A1 (en) * 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Novel intron sequences
KR20210122917A (ko) 2013-03-14 2021-10-12 샤이어 휴먼 지네틱 테라피즈 인크. Cftr mrna 조성물 및 관련 방법 및 사용
PL3467108T3 (pl) 2013-03-14 2024-09-30 Translate Bio, Inc. Sposoby oczyszczania informacyjnego rna
ES2707966T3 (es) 2013-10-22 2019-04-08 Translate Bio Inc Terapia de ARNm para la deficiencia en síntesis de argininosuccinato
EA034103B1 (ru) 2013-10-22 2019-12-27 Транслейт Био, Инк. СПОСОБ ЛЕЧЕНИЯ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК
CN103901209B (zh) * 2014-02-18 2016-05-25 王明丽 一种重组蛋白ie1包被酶标反应板的制备方法及定量检测人血浆hcmv中和抗体试剂盒
PT3134506T (pt) 2014-04-25 2019-10-31 Translate Bio Inc Métodos de purificação de rna mensageiro
CN106459999B (zh) * 2014-06-18 2024-10-11 新加坡科技研究局 用于高水平表达的新型启动子
US10611800B2 (en) 2016-03-11 2020-04-07 Pfizer Inc. Human cytomegalovirus gB polypeptide
EA201991747A1 (ru) 2017-02-27 2020-06-04 Транслейт Био, Инк. НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR
MX2019013752A (es) 2017-05-16 2020-07-20 Translate Bio Inc Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones.
WO2019060649A1 (en) * 2017-09-22 2019-03-28 Voyager Therapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATING HUNTINGTON'S DISEASE
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MX2021005969A (es) 2018-11-21 2021-09-14 Translate Bio Inc Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr nebulizado.
US11629172B2 (en) 2018-12-21 2023-04-18 Pfizer Inc. Human cytomegalovirus gB polypeptide
TWI810589B (zh) 2020-06-21 2023-08-01 美商輝瑞股份有限公司 人巨細胞病毒糖蛋白B(gB)多肽

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RU2717986C2 (ru) * 2013-12-30 2020-03-27 Куревак Аг Искусственные молекулы нуклеиновой кислоты
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