EA009553B1 - Замещённые тетралины и инданы - Google Patents
Замещённые тетралины и инданы Download PDFInfo
- Publication number
- EA009553B1 EA009553B1 EA200500515A EA200500515A EA009553B1 EA 009553 B1 EA009553 B1 EA 009553B1 EA 200500515 A EA200500515 A EA 200500515A EA 200500515 A EA200500515 A EA 200500515A EA 009553 B1 EA009553 B1 EA 009553B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ureido
- ylsulfanyl
- trifluoromethoxyphenyl
- ethyl
- indan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41993502P | 2002-10-21 | 2002-10-21 | |
| US49527003P | 2003-08-15 | 2003-08-15 | |
| PCT/US2003/033090 WO2004037778A1 (en) | 2002-10-21 | 2003-10-17 | Substituted tetralins and indanes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200500515A1 EA200500515A1 (ru) | 2005-10-27 |
| EA009553B1 true EA009553B1 (ru) | 2008-02-28 |
Family
ID=32179771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200500515A EA009553B1 (ru) | 2002-10-21 | 2003-10-17 | Замещённые тетралины и инданы |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1569897A1 (es) |
| JP (1) | JP2006503916A (es) |
| KR (1) | KR20050055773A (es) |
| AU (1) | AU2003277441B2 (es) |
| BR (1) | BR0315596A (es) |
| CA (1) | CA2502661A1 (es) |
| CR (1) | CR7795A (es) |
| EA (1) | EA009553B1 (es) |
| EG (1) | EG24842A (es) |
| HR (1) | HRP20050335A2 (es) |
| MX (1) | MXPA05004191A (es) |
| NO (1) | NO20052199L (es) |
| NZ (1) | NZ539510A (es) |
| PL (1) | PL376325A1 (es) |
| RS (1) | RS20050318A (es) |
| TW (1) | TW200418773A (es) |
| WO (1) | WO2004037778A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006503915A (ja) * | 2002-10-21 | 2006-02-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 置換テトラリンおよびインダンを用いたｘ症候群の治療 |
| AU2003279996B2 (en) * | 2002-10-21 | 2009-07-09 | Janssen Pharmaceutica, N.V. | Substituted tetralins and indanes and their use |
| AR048931A1 (es) * | 2004-04-21 | 2006-06-14 | Janssen Pharmaceutica Nv | Proceso para la preparacion de derivados de tetralina sustituida e indano sustituido y preparacion de intermediarios de sintesis |
| AU2005302669A1 (en) * | 2004-10-27 | 2006-05-11 | Neurogen Corporation | Diaryl ureas as CB1 antagonists |
| WO2007071766A2 (en) | 2005-12-22 | 2007-06-28 | Transtech Pharma | Phenoxy acetic acids as ppar delta activators |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997036579A1 (en) * | 1996-03-30 | 1997-10-09 | Glaxo Group Limited | Use of agonists of the peroxisome proliferator activated receptor alpha for treating obesity |
| WO2000023407A2 (en) * | 1998-10-16 | 2000-04-27 | Glaxo Group Limited | Ureido-thiobutyric acid derivatives as ppar-agonists |
| WO2002064130A1 (en) * | 2001-02-15 | 2002-08-22 | Pfizer Products Inc. | Proliferative activator receptor (ppar) compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2400021A1 (en) * | 2000-02-18 | 2001-08-23 | Merck & Co., Inc. | Aryloxyacetic acids for diabetes and lipid disorders |
| NZ525119A (en) * | 2000-10-05 | 2005-04-29 | Bayer Ag | Propionic acid derivatives |
| WO2002044129A1 (fr) * | 2000-11-29 | 2002-06-06 | Kyorin Pharmaceutical Co., Ltd. | Dérivés d'acide carboxylique substitués |
| AU2002222573A1 (en) * | 2000-12-05 | 2002-06-18 | Kyorin Pharmaceutical Co. Ltd. | Substituted carboxylic acid derivatives |
| WO2002050047A1 (en) * | 2000-12-20 | 2002-06-27 | Glaxo Group Limited | Substitued oxazoles and thiazoles as hppar alpha agonists |
| UA82835C2 (en) * | 2001-12-03 | 2008-05-26 | Reddys Lab Ltd Dr | ?-aryl-?-oxysubstituted propionuc acid derivatives and pharmaceutical composition based thereon |
| JP2006503915A (ja) * | 2002-10-21 | 2006-02-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 置換テトラリンおよびインダンを用いたｘ症候群の治療 |
| AU2003279996B2 (en) * | 2002-10-21 | 2009-07-09 | Janssen Pharmaceutica, N.V. | Substituted tetralins and indanes and their use |
-
2003
- 2003-10-17 BR BR0315596-0A patent/BR0315596A/pt not_active IP Right Cessation
- 2003-10-17 JP JP2005501629A patent/JP2006503916A/ja not_active Withdrawn
- 2003-10-17 EP EP03809577A patent/EP1569897A1/en not_active Withdrawn
- 2003-10-17 MX MXPA05004191A patent/MXPA05004191A/es active IP Right Grant
- 2003-10-17 NZ NZ539510A patent/NZ539510A/en not_active IP Right Cessation
- 2003-10-17 CA CA002502661A patent/CA2502661A1/en not_active Withdrawn
- 2003-10-17 AU AU2003277441A patent/AU2003277441B2/en not_active Ceased
- 2003-10-17 EA EA200500515A patent/EA009553B1/ru not_active IP Right Cessation
- 2003-10-17 RS YUP-2005/0318A patent/RS20050318A/sr unknown
- 2003-10-17 WO PCT/US2003/033090 patent/WO2004037778A1/en active Application Filing
- 2003-10-17 KR KR1020057006795A patent/KR20050055773A/ko not_active Application Discontinuation
- 2003-10-17 PL PL03376325A patent/PL376325A1/xx not_active Application Discontinuation
- 2003-10-21 TW TW092129192A patent/TW200418773A/zh unknown
-
2005
- 2005-04-14 HR HR20050335A patent/HRP20050335A2/hr not_active Application Discontinuation
- 2005-04-18 CR CR7795A patent/CR7795A/es not_active Application Discontinuation
- 2005-04-20 EG EGNA2005000152 patent/EG24842A/xx active
- 2005-05-04 NO NO20052199A patent/NO20052199L/no not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997036579A1 (en) * | 1996-03-30 | 1997-10-09 | Glaxo Group Limited | Use of agonists of the peroxisome proliferator activated receptor alpha for treating obesity |
| WO2000023407A2 (en) * | 1998-10-16 | 2000-04-27 | Glaxo Group Limited | Ureido-thiobutyric acid derivatives as ppar-agonists |
| WO2002064130A1 (en) * | 2001-02-15 | 2002-08-22 | Pfizer Products Inc. | Proliferative activator receptor (ppar) compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| TW200418773A (en) | 2004-10-01 |
| PL376325A1 (en) | 2005-12-27 |
| CA2502661A1 (en) | 2004-05-06 |
| HRP20050335A2 (en) | 2006-05-31 |
| JP2006503916A (ja) | 2006-02-02 |
| EG24842A (en) | 2010-10-13 |
| CR7795A (es) | 2012-10-25 |
| RS20050318A (en) | 2007-09-21 |
| EP1569897A1 (en) | 2005-09-07 |
| WO2004037778A1 (en) | 2004-05-06 |
| MXPA05004191A (es) | 2006-01-27 |
| AU2003277441B2 (en) | 2009-05-07 |
| BR0315596A (pt) | 2005-09-06 |
| KR20050055773A (ko) | 2005-06-13 |
| EA200500515A1 (ru) | 2005-10-27 |
| AU2003277441A1 (en) | 2004-05-13 |
| NZ539510A (en) | 2008-01-31 |
| NO20052199L (no) | 2005-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |