EA008538B1 - Способы и композиции для лечения сердечно-сосудистого заболевания доставкой генов in vivo - Google Patents
Способы и композиции для лечения сердечно-сосудистого заболевания доставкой генов in vivo Download PDFInfo
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- EA008538B1 EA008538B1 EA200200533A EA200200533A EA008538B1 EA 008538 B1 EA008538 B1 EA 008538B1 EA 200200533 A EA200200533 A EA 200200533A EA 200200533 A EA200200533 A EA 200200533A EA 008538 B1 EA008538 B1 EA 008538B1
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
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- Molecular Biology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
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- Biophysics (AREA)
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- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43515699A | 1999-11-05 | 1999-11-05 | |
| US60908000A | 2000-06-30 | 2000-06-30 | |
| PCT/US2000/030345 WO2001034208A1 (en) | 1999-11-05 | 2000-11-03 | Techniques and compositions for treating cardiovascular disease by in vivo gene delivery |
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| Publication Number | Publication Date |
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| EA200200533A1 EA200200533A1 (ru) | 2002-12-26 |
| EA008538B1 true EA008538B1 (ru) | 2007-06-29 |
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| EA200200533A EA008538B1 (ru) | 1999-11-05 | 2000-11-03 | Способы и композиции для лечения сердечно-сосудистого заболевания доставкой генов in vivo |
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|---|---|
| EP (1) | EP1225921A1 (https=) |
| JP (1) | JP2003513942A (https=) |
| KR (1) | KR20020049031A (https=) |
| CN (1) | CN1433325A (https=) |
| AU (1) | AU784392B2 (https=) |
| CA (1) | CA2389524A1 (https=) |
| EA (1) | EA008538B1 (https=) |
| HK (1) | HK1048593A1 (https=) |
| NZ (1) | NZ546670A (https=) |
| WO (1) | WO2001034208A1 (https=) |
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| WO2001034208A1 (en) * | 1999-11-05 | 2001-05-17 | The Regents Of The University Of California | Techniques and compositions for treating cardiovascular disease by in vivo gene delivery |
| US20030093147A1 (en) * | 2001-11-13 | 2003-05-15 | Ogle Matthew F. | Medical devices that stimulate growth factor production |
| KR100562824B1 (ko) | 2002-03-20 | 2006-03-23 | 주식회사 바이로메드 | 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자 |
| PL195457B1 (pl) * | 2002-08-05 | 2007-09-28 | Zaklady Farm Polpharma Sa | Kaseta ekspresyjna, dwucistronowy wektor plazmidowy, środek farmaceutyczny oraz ich zastosowanie |
| GB2437893A (en) * | 2006-07-25 | 2007-11-07 | Celladon Corp | Extended antegrade epicardial coronary infusion of adeno-associated viral vectors for gene therapy |
| EP2559698B1 (en) * | 2007-08-24 | 2014-11-12 | Julius-Maximilians-Universität Würzburg | Mutant double cyclized receptor peptides inhibiting beta 1-adrenoceptor antibodies |
| JP5579164B2 (ja) | 2008-04-09 | 2014-08-27 | ビロメッド カンパニー， リミテッド | 凍結乾燥ｄｎａ製剤、組成物、及び凍結乾燥ｄｎａ製剤を製造する方法 |
| WO2010078624A1 (en) * | 2009-01-07 | 2010-07-15 | Vegenics Limited | Materials and methods for the treatment of hypertension |
| KR101006106B1 (ko) * | 2009-06-04 | 2011-01-07 | 김현태 | 전·자기장 차단 전열선 |
| US10155099B2 (en) | 2009-09-21 | 2018-12-18 | Cook Regentec Llc | Method for infusing stem cells |
| CA2864100A1 (en) | 2012-02-14 | 2013-08-22 | The Regents Of The University Of California | Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions |
| WO2013184782A2 (en) | 2012-06-05 | 2013-12-12 | Muffin Incorporated | Catheter systems and methods useful for cell therapy |
| US10639351B2 (en) | 2013-10-22 | 2020-05-05 | Helixmith Co., Ltd. | Method for treating amyotrophic lateral sclerosis with a polynucleotide encoding two or more isoforms of hepatocyte growth factor |
| US20210393805A1 (en) * | 2018-05-16 | 2021-12-23 | University Of Massachusetts | Perfusion-based delivery of recombinant aav vectors for expression of secreted proteins |
| KR20210027493A (ko) | 2018-07-19 | 2021-03-10 | 주식회사 헬릭스미스 | 네이키드 dna 유전자 요법을 위한 동결 건조된 약제학적 조성물 |
| JP7717677B2 (ja) * | 2019-08-07 | 2025-08-04 | ノースウェスタン ユニバーシティ | 心臓内遺伝子送達のための材料及び方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996026742A1 (en) * | 1995-02-28 | 1996-09-06 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| WO1998032859A1 (en) * | 1997-01-29 | 1998-07-30 | Cornell Research Foundation, Inc. | Multiple site delivery of adenoviral vector for the induction of angiogenesis |
| WO1998050079A2 (en) * | 1997-05-06 | 1998-11-12 | The Regents Of The University Of California | Techniques and compositions for treating heart failure and ventricular remodeling by in vivo delivery of angiogenic transgenes |
| WO1999040945A2 (en) * | 1998-02-11 | 1999-08-19 | The Regents Of The University Of California | Combination of a nucleic acid and a vasoactive agent for enhanced gene delivery |
| WO2000038518A1 (en) * | 1998-12-28 | 2000-07-06 | Arch Development Corporation | Efficient and stable (in vivo) gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors |
Family Cites Families (2)
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|---|---|---|---|---|
| WO2001034208A1 (en) * | 1999-11-05 | 2001-05-17 | The Regents Of The University Of California | Techniques and compositions for treating cardiovascular disease by in vivo gene delivery |
| US5792453A (en) * | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20020049031A (ko) | 2002-06-24 |
| EP1225921A1 (en) | 2002-07-31 |
| CA2389524A1 (en) | 2001-05-17 |
| NZ546670A (en) | 2009-02-28 |
| AU1460401A (en) | 2001-06-06 |
| JP2003513942A (ja) | 2003-04-15 |
| WO2001034208A1 (en) | 2001-05-17 |
| EA200200533A1 (ru) | 2002-12-26 |
| HK1048593A1 (zh) | 2003-04-11 |
| AU784392B2 (en) | 2006-03-23 |
| CN1433325A (zh) | 2003-07-30 |
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